Clinical trials: Frail
Frailty, Anesthesia Induction
ED50 of Remimazolam for Anesthesia Induction in Frail Elderly Patients
This study aimed to determine the median effective dose (ED50) of remimazolam for loss of consciousness (LOC) in elderly and frail elderly patients using the Dixon up-and-down method, while utilizing a novel Respiratory Volume…
- Trial name
- NCT07467603
- Testing
- Remimazolam Tosilate
- Where
- China
- Volunteers
- 58 people
- Sponsor
- The First Hospital of Hebei Medical University
Frail Elderly Syndrome, Transitional Care
Models of Care in the Transition From the Secondary to the Primary Sector Among the Frailest Elderly
In most Western countries the elderly population increases rapidly. In Denmark, the population of elderly aged 75 years or older may amount to nearly 15 % of the entire population in 2050 compared to 9 % today (2017).
- Conditions
- Frail Elderly Syndrome, Transitional Care, Frailty, Readmission
- Trial name
- NCT03796923
- Testing
- Early follow-up visit after discharge, Comprehensive geriatric assessment (CGA), Continued geriatric care
- Where
- Denmark
- Volunteers
- 3,340 people
- Sponsor
- University of Aarhus
Frail Elderly Patients, Hypogonadal Males
Effect of Testosterone on Elderly Frail Men With Testosterone Deficiency
The purpose of this study is to increase the functional level of the elderly to thereby reduce fall risk, improve motor skills, and increase psychological well-being, as well as to assess whether the restoration of a normal…
- Conditions
- Frail Elderly Patients, Hypogonadal Males, Testosterone Replacement Therapy, Falls (Accidents) in Old Age
- Trial name
- NCT07512323
- Testing
- Nebido (Testosterone Undecanoate)
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Rune Skovgaard Rasmussen
Colon Cancer, Fragility
Prehabilitation in Frail Colon Cancer
Objectives To investigate the impact of tele-supervised prehabilitation on functional capacity in frail colon cancer patients undergoing colorectal resection and to evaluate the effects of prehabilitation on muscle strength and…
- Trial name
- NCT03097224
- Testing
- Prehabilitation
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cancer of Head and Neck
Study Comparing Pembrolizumab With Methotrexate in Elderly, Frail or Cisplatin-ineligible Patients With Head and Neck Cancers
The study is designed as an open-label, randomized, prospective, multicenter, phase II study comparing pembrolizumab with methotrexate in elderly, frail or cisplatin-ineligible patients with squamous carcinoma of the head and…
- Trial name
- ELDORANDO (NCT03193931)
- Testing
- Pembrolizumab Injection, Methotrexate Injectable Solution
- Where
- Germany
- Volunteers
- 47 people
- Sponsor
- AIO-Studien-gGmbH
Hip Fractures, Frailty
AI-Supported Physiotherapy After Hip Fracture in Frail Older Adults
Purpose Hip fractures in older adults often cause a serious loss of strength and independence. Physical therapy helps people recover, but patients do not always exercise consistently or correctly.
- Trial name
- Fisio-ACTIVA (NCT07857707)
- Testing
- Conventional hospital physiotherapy, Automated motivational support and movement-capture system
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Frail Elderly Syndrome
Protocol of Geriatric Rehabilitation in Patients of 60 and Older Who Live in Moscow Boarding Houses or Nursing Homes
After screening complex geriatric assessment (CGA) the participants will undergo geriatric rehabilitation programs. After termination of 21-day program, CGA will be repeated and subjects will get a program of long-term…
- Trial name
- POSTSCRIPTUM (NCT05740436)
- Testing
- Geriatric rehabilitation program based on CGA
- Where
- Russia
- Volunteers
- 420 people
- Sponsor
- Pirogov Russian National Research Medical University
Frail Elderly
Resistance Training to Optimize Health in Pre-frail Older Adults
Exercise programs, particularly resistance training programs using weights or resistance bands, can help improve or maintain mobility and function in older adults, preserve independent living, and improve quality of life.
- Trial name
- NCT02593084
- Testing
- Higher Intensity Resistance Training, Lower Intensity Resistance Training
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McMaster University
Frailty
Blood Flow Restriction Training in Pre-frail and Frail Older Adults
Frailty is most often defined as a syndrome of physiological decline in late life, characterized by marked vulnerability to adverse health outcomes.
- Trial name
- NCT04507152
- Testing
- Blood flow restriction resistance training, Resistance training
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- National Cheng Kung University
Diffuse Large B-cell Lymphoma
Rituximab Plus Bendamustine as Front Line Treatment in Frail Elderly (>70 Years) Patients With DLBCL: a Phase II Multicenter Study of the FIL
The purpose of the study is to evaluate feasibility and efficacy of rituximab-bendamustine (R-B)combination in elderly patients affected by diffuse large B-cell lymphoma and defined as frail according to CGA.
- Trial name
- NCT01990144
- Testing
- Bendamustine+Rituximab
- Where
- 52 sites in Italy
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Fondazione Italiana Linfomi - ETS
Frail Elderly
Factors Predisposing to Inappropriate Transfers of Nursing Home Residents to Emergency Departments
According to the data of our nursing homes (NH) research network (REHPA - Gérontopôle Toulouse, 345 nursing home in France), 13.5% of NH residents are hospitalized every 3 months or about 50% per year.
- Trial name
- FINE (NCT02677272)
- Testing
- Appropriateness of NH resident's transfer to ED
- Where
- 16 sites in France
- Volunteers
- 1,040 people
- Sponsor
- University Hospital, Toulouse
Poly Pharmacy, Frail Elderly
Applying a Multidisciplinary Intervention for Drug Adequacy in an Intermediate Care Hospital (AMIDA-ICH)
The goal of this clinical trial is to learn if a multi-professional (conducted by geriatricians, clinical pharmacists, nurses) medication revision, centered on patients' goals and characteristics, can improve treatment adequacy…
- Trial name
- AMIDA-ICH (NCT07015112)
- Testing
- Patient-centered multidisciplinary treatment review
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Parc Sanitari Pere Virgili
Aging
Effects of Functional Incidental Training in VA NHCU Residents
This research on Functional Incidental Training ( FIT) primarily involves women residing in community nursing homes. It is an individualized rehabilitative protocol intended to improve mobility, endurance, strength and continence…
- Trial name
- NCT00013507
- Testing
- Falls
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- US Department of Veterans Affairs
Postural Imbalance, Gait, Unsteady
A Device for Screening of Fall Risk in the Elderly
This study evaluates the screening accuracy of a device (OAK) in assessing fall risk in the elderly, compared to the assessment provided by the Algorithm for Fall Risk Assessment of the Centers for Disease Control and Prevention…
- Trial name
- NCT02655796
- Testing
- OAK
- Where
- Italy
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Obesity
MOWI Qualitative Assessment
This qualitative study seeks to assess whether mobile health technologies are helpful for older adults. It is the first in a series of four studies whose overarching goal is to conduct a program of pilot research aimed at…
- Trial name
- NCT03041831
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Parkinson Disease, Frail Elderly
Innovative Models in the Rehabilitation of the Elderly With Parkinson's Disease Through Technological Innovation
The final goal of the present study is to propose a new approach in the Parkinson's Disease rehabilitation, focused on the use of robotic devices and to check the results not only at the end of the treatment but also in the long…
- Conditions
- Parkinson Disease, Frail Elderly, Robotic Devices in Rehabilitation
- Trial name
- NCT04087031
- Testing
- control arm, virtual reality games, robotic treadmill
- Where
- 2 sites in Italy
- Volunteers
- 195 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Older Adults (65 Years and Older), Outpatient Treatment
Feasibility of Virtual Reality-assisted Ergometer Cycling in Addition to Regular Rehabilitation During Municipality-based Inpatient Rehabilitation Care
VR-C-REHAB is a single-group pilot and feasibility study examining the practicality of implementing virtual-reality-assisted ergometer cycling as an adjunct to usual municipal inpatient rehabilitation for older adults (≥65…
- Conditions
- Older Adults (65 Years and Older), Outpatient Treatment, Rehabilitation Frail Elderly Subjects
- Trial name
- VR-C-REHAB (NCT07459439)
- Testing
- VR cycling
- Where
- 2 sites in Denmark
- Volunteers
- 12 people
- Sponsor
- Horsholm Municipality
Pre-frail Elderly
Effects of Metformin in Pre-frail Elderly
The purpose of this study is to investigate the effects of metformin to prevent frailty in pre-frail non-diabetic elderly. Several outcomes measured in this study are frailty status, quality of life, handgrip strength, gait…
- Trial name
- NCT02325245
- Testing
- Metformin
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- Universitas Indonesia
Exergaming, Frail Elderly
Home-Based Exergame Program for Community-Dwelling Older Adults
The purpose of this study was to investigate the effect of a home-based exergame program on physical function, fall efficacy, depression, and quality of life in older adults.
- Trial name
- NCT05802537
- Testing
- Home-based exergame program, Online education on fall prevention and musculoskeletal health management
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kyungdong University
Movement Disorders, Aging
Effects of Exercise Poles on Older Adults During Exercise Walking
This study uses a patented type of exercise poles, developed to assist runners rehabilitating from lower body injuries. These poles may offer older adults improved stability, reduced fear of falling, and lessened lower body pain…
- Trial name
- NCT00037167
- Testing
- Exercise poles
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)