Clinical trials: Frail
Complication, Postoperative, Perioperative/Postoperative Complications
The Impact of Prehabilitation Bundle on Perioperative Outcome for Frail Elderly Patients Undergoing Major Abdominal Surgery
This study aims to study the efficacy of a preoperative "bundle" of interventions, which consists of preoperative physiotherapy, nutritional support and cognitive exercises on elderly frail patients undergoing major abdominal…
- Trial name
- NCT02921932
- Testing
- Ensure, Resource 2.0 and Glucerna, Cognitive Training, Memory Card Game, 'Threshold' Inspiratory Muscle Trainer, Respironics of New Jersey Inc
- Where
- Singapore
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Glioblastoma Multiforme
Short Course vs. Standard Course Radiotherapy in Elderly and/or Frail Patients With Glioblastoma Multiforme
This is a multi-centre prospective, non-inferiority trial. Patients will be randomized to two treatment groups in a 1:1 ratio and will be stratified by age, Karnofsky Performance Status and extent of the surgical resection.
- Trial name
- NCT01450449
- Testing
- Radiotherapy
- Where
- 15 sites in Argentina, Belarus and 12 more
- Volunteers
- 115 people
- Sponsor
- International Atomic Energy Agency
Aging, Frail Elderly
The Effect of Testosterone Supplementation on Rehabilitation Outcomes
The objective of this project is to determine the safety and efficacy of testosterone supplementation as an adjunct to traditional rehabilitation therapy in the care of deconditioned older men.
- Conditions
- Aging, Frail Elderly, Rehabilitation
- Trial name
- NCT00037999
- Testing
- Testosterone supplement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- US Department of Veterans Affairs
Frailty Syndrome, Sarcopenia
Design and Validation of FEXO: A Playful Exercise Program for Institutionalized Frail Older Adults
This multicenter randomized controlled trial aims to evaluate the effectiveness of a playful multicomponent exercise intervention (FEXO - Fun Exercise for Older Adults) on intrinsic capacity, frailty, and functional health in…
- Trial name
- FEXO-FRAIL (NCT07133581)
- Testing
- FEXO (Fun Exercise for Older Adults)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Frail Elderly, Homebound Persons
Improving Function in Older Veterans With Hospital-Associated Deconditioning
The investigators plan to test an innovative, home-based, short duration, high intensity exercise program designed for application in the immediate post-hospitalization period in older Veterans.
- Trial name
- NCT02696382
- Testing
- Progressive High Intensity Therapy (PHIT), Usual Care (UC)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Frailty Syndrome, Frail Elderly Syndrome
Effectiveness of a Multimodal Intervention on Function in Older Frail People With Diabetes in Latinamerican
Randomized clinical trial, international, multicentre, single-blind, two parallel groups, pragmatic. It will be carried out by investigators in several Latin American countries (Chile, Colombia, Mexico and Peru) and with random…
- Conditions
- Frailty Syndrome, Frail Elderly Syndrome, Diabetes Mellitus, Type 2
- Trial name
- DIABFRAIL (NCT04504968)
- Testing
- Multimodal intervention, Usual care group
- Where
- Colombia
- Volunteers
- 713 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Healthy Volunteers, Frail Volunteers
Sampling of Human Microbiota in Order to Test, on a Mouse Model, Individualized Intervention Strategies During Aging
Human microbial flora transfer studies in rodent models have clearly identified that age-associated microbiota dysbiosis can play a decisive role with respect to pathologies or complications linked to aging: increased intestinal…
- Trial name
- FRAGIBIOTE (NCT04753580)
- Testing
- Stool collection
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Gastric Cancer (GC), Frailty in Adult Surgery
Temporal Transformation Mechanism and Intervention Strategies of Frail-related Dietary Behaviors in Older Gastric Cancer Survivors
The investigators invite participants to participate in the research project "Research on the Maintenance Mechanism and Intervention Strategies of Dietary Behavior Changes Related to Frailty in Elderly Gastric Cancer Survivors".
- Trial name
- NCT07176455
- Testing
- Anti-frailty dietary behavior intervention
- Where
- China
- Volunteers
- 438 people
- Sponsor
- Nanjing Medical University
Thoracic, Thoracic Neoplasm
A Prospective Study Frailty for Esophagectomy and Lung Resection in Thoracic Surgery
The purpose of this study is to develop an all-encompassing frailty model using laboratory and functional studies. A frailty model will help us determine prior to surgery who will require rehabilitation and skilled nursing needs…
- Conditions
- Thoracic, Thoracic Neoplasm, Lung Cancer, Esophageal Cancer
- Trial name
- NCT03413449
- Testing
- Frailty model
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- The Cleveland Clinic
Elderly, Frail
Are Geriatric Out-patient Care Better Than Usual Care?
Frailty and multimorbidity is one of the biggest challenges of todays health care due to the demographic development with more and more elderly surviving many diseases that was mortal just a few decades ago.
- Trial name
- NCT02923843
- Testing
- Comprehensive Geriatric Assessment
- Where
- Sweden
- Volunteers
- 450 people
- Sponsor
- Region Skane
Diabetes Type 2, Frail Elderly Syndrome
Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve…
- Conditions
- Diabetes Type 2, Frail Elderly Syndrome, Mitochondrial Function, Bioenergetics, Functionality
- Trial name
- MITOSTRENGTH (NCT07828847)
- Testing
- Short-duration resistance training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Global Medical Assessment of Elderly Frail Patients
Optimization of Drug Treatment in Hospitalized Elderly (OMAGE)
A randomized trial has been designed to determine if this complex intervention can significantly decrease the risk of unplanned readmissions in this very elderly population, compared with usual care.
- Trial name
- OMAGE (NCT00450034)
- Testing
- drug - oriented multifaceted intervention
- Where
- France
- Volunteers
- 665 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Kidney Disease
Chronic Kidney Disease Among Frail Elderly
Chronic kidney disease is a common diagnosis in the elderly population and it is associated with significant morbidity and health care costs. The prevalence rates increase with age to about 40% for adults aged > 65 years.
- Trial name
- FRED-CKD (NCT02351349)
- Testing
- multidisciplinary intervention
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Sameena Iqbal