Clinical trials: Frail
Frailty, Cognition
Promoting Independent Living in Frail Older Adults by Improving Cognition and Gait Ability and Using Assistive Products
A strategy involving 6 partners was planned, targeting the components of education, innovation, and practice-based research with knowledge transfer into clinical practice.The project MIND\&GAIT aims to promote independent living…
- Conditions
- Frailty, Cognition, Mild Cognitive Impairment
- Trial name
- MIND&GAIT (NCT03390478)
- Testing
- Combined Intervention Group
- Where
- Portugal
- Volunteers
- 62 people
- Sponsor
- Escola Superior de Enfermagem de Coimbra
Frailty
Blood Flow Restriction on Functional Mobility in Pre-frail Older Adults
This study investigates the effect of blood flow restriction with resistance exercise on functional mobility in pre-frail older adults.
- Trial name
- NCT05209685
- Testing
- Resistance exercise on the lower extremities, Resistance exercise on the lower extremities with blood flow restriction
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- National Cheng Kung University
Elderly
Seamless Follow up and Support System for Frail Elderly Living at Home
The object of the present project is to promote the prevention of disability by providing 1) a feedback and motivational coaching to the user, 2) relevant clinical parameters to the healthcare professionals in order to support…
- Trial name
- FRAGIL-IT (NCT03468647)
- Testing
- soles, weighting machine, gripping force
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Frail Elderly People
Continuum of Care for Frail Elderly People
The present study "Continuum of care for frail elderly people" form part of the research programme "Support for frail elderly persons - from prevention to palliation" (www.vardalinstitutet.net) which comprises research into three…
- Trial name
- NCT01260493
- Testing
- integrated health care chain
- Where
- Sweden
- Volunteers
- 181 people
- Sponsor
- Vardalinstitutet The Swedish Institute for Health Sciences
Fall Prevention, Autonomy of Older People
Advanced Practice Nurses for Fall Incidence PrevenTion in Very Old Robust Adults
APN-FIT is a hybrid type 1 clinical trial comparing the effect of an APN delivered fall prevention programme with standard care in non-frail patients.
- Conditions
- Fall Prevention, Autonomy of Older People, Frail Elderly, Advanced Practice Nursing
- Trial name
- APN-FIT (NCT06617806)
- Testing
- Follow-up by the Advanced Practice Nurse
- Where
- France
- Volunteers
- 386 people
- Sponsor
- Nantes University Hospital
Quality of Life
Anesthesia Geriatric Evaluation and Quality of Life After Peripheral Vascular Surgery
A prospective observational cohort study to assess the predictive value of preoperative frailty on postoperative quality of life in peripheral vascular surgery patients.
- Trial name
- AGE-VASC (NCT02820831)
- Where
- Netherlands
- Volunteers
- 88 people
- Sponsor
- St. Antonius Hospital
Fragility
Motorized Platform and Autonomy Among the Frail and Pre-frail Older Adult (PLATAUTONOMIE)
Highly diversified programs of physical activity in older people have shown their effectiveness in terms of improving functional capacities. Only one of these programs, to date, has used a motorized platform.
- Trial name
- NCT02850731
- Testing
- plate-forme Hu360®
- Sponsor
- University Hospital, Toulouse
Weight Loss
Measuring Eating, Activity and Strength: Understanding the Response -Using Protein
The purpose of the trial is to assess the effects of weight loss on functional status and lean muscle mass in frail, obese older adults (>/= 60) who participate in a 6 month weight reduction intervention.
- Trial name
- MEASUR-UP (NCT01715753)
- Testing
- Protein supplementation, Diet counseling and group education lessons
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Duke University
Multiple Myeloma, Myeloma
Multicenter Open Label Phase 3 Study of Isatuximab Plus Lenalidomide and Dexamethasone With/Without Bortezomib in the Treatment of Newly Diagnosed Non Frail Transplant Ineligible Multiple Myeloma Elderly Patients (≥ 65; < 80 Years).
Overall the issue of patients above 65-70 years of age being that it is impossible for most of them to undergo an intensive treatment like autologous stem cell transplant with little prospect of debulking effectively the bone…
- Trial name
- NCT04751877
- Testing
- Isatuximab, Lenalidomide, Bortezomib
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Poitiers University Hospital
Frail Elderly Syndrome, Chronic Disease
Implementing Advance Care Planning Conversation Tools in Family Practice
This study evaluates the use of advance care planning conversation tools with patients attending their family doctor's office. Patients complete tools about their values and wishes, and a health care provider uses a structured…
- Trial name
- NCT03508557
- Testing
- Advance care planning tools
- Where
- 4 sites in Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Pre-frail Senior Adults
What Are the Effects of a Bilateral Hip Exoskeleton During Daily Use by 65+ Adults?
Despite the huge popularity exoskeletons have gained in the past years and the benefits that they have shown to provide to users, there are still many aspects of wearing an exoskeleton that have yet to be determined.
- Trial name
- NCT06041100
- Testing
- Exoskeleton
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Aalborg University
CANCER
ProActIF-01 Trial: Feasibility Study of an Individualized Program of Nutrition and Adapted Physical Activity in Frail Patients With Advanced Digestive Cancers
The ProActIF-01 trial aims to assess the feasibility of a supervised 8-week combined APA and nutrition individualized program, in advanced digestive cancer patients.
- Trial name
- ProActIF-01 (NCT05441163)
- Testing
- APA and nutrition intervention
- Where
- 18 sites in France
- Volunteers
- 50 people
- Sponsor
- Institut Curie
Frailty, Old Age; Debility
The Effects of a Tele-health Program
Frailty is a state of being vulnerable and functional disable due to age-related decline of multiple physiological systems, and is often associated with higher risk of falls, institutionalization, hospitalization, disability…
- Trial name
- NCT05267444
- Testing
- Individualized motion-based interactive game program
- Where
- Hong Kong
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Frail Elderly Syndrome, Malnutrition Elderly
Effect of a Combined Exercise and Anti-Inflammatory Nutritional Intervention in Frail Older Adults
The goal of this clinical trial is to evaluate whether a combined intervention of therapeutic exercise and anti-inflammatory nutritional supplementation improves physical performance and reduces systemic inflammation in frail…
- Trial name
- AliFrail (NCT07182292)
- Testing
- Anti-Inflammatory Supplement, Conventional Nutritional Supplement
- Volunteers
- 158 people
- Sponsor
- Fundacion Miguel Servet
Multiple Chronic Diseases Among Diabetes Mellitus, Chronic Obstructive Pulmonary Diseases and Heart Failure
Life-long Monitoring of Frail Patients With Chronic Diseases
The purpose of this study is to evaluate whether telemonitoring of frail patients with chronic diseases produces benefits in terms of reduced readmissions, improved health related quality of life, and improved health status.
- Trial name
- NCT01608932
- Testing
- Telemonitoring for frail patients with chronic diseases
- Where
- 7 sites in Italy
- Volunteers
- 152 people
- Sponsor
- Regione Veneto
Frailty
Effects of Low-Speed and High-Speed Resistance Training Programs on Frailty Status
The present study refers to a three-arm randomized controlled trial that investigated the effects of two types of RT on frailty status, physical performance, cognitive function, and blood pressure of prefrail and frail older…
- Trial name
- RTF (NCT04868071)
- Testing
- Physical Exercise
- Where
- 2 sites in Brazil
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
COVID, Drug Effect
Simulation of Risk of Adverse Drug Events Associated With the Initiation of Drugs Repurposed for the Treatment of COVID-19 in Frail Elderly Adults With Polypharmacy
This retrospective study aims to perform a medication risk stratification using drug claims data and to simulate the impact of the addition of various repurposed drugs on the Medication Risk Score (MRS) in elderly people enrolled…
- Conditions
- COVID, Drug Effect, Drug Interaction, Adverse Drug Event
- Trial name
- NCT04339634
- Testing
- Simulation of Repurposed Drugs for COVID-19
- Where
- United States
- Volunteers
- 12,873 people
- Sponsor
- Tabula Rasa HealthCare
Alzheimer s Disease, Vascular Dementia
Predictors of Emergency Department Use in Frail Patients
When admitted to the emergency department (ED), elderly non-autonomous patients show high risk of adverse health outcomes. The prompt identification of ED use risk factors in such population is hence needed.
- Conditions
- Alzheimer s Disease, Vascular Dementia, Frailty, Elderly
- Trial name
- THE-Spoke 10 (NCT07259499)
- Testing
- Plasma phosphorylated Tau 181
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- University of Pisa
Frailty, Frail Older Adults
Cognitive Groove (Brought to You by GERAS DANCE)
The goal of this clinical trial is to determine the effect of a community-based rehabilitation intervention (Cognitive Groove, Brought to you by GERAS DANCE), compared to usual care, on clinical outcomes in community-dwelling…
- Conditions
- Frailty, Frail Older Adults, Frailty in Aging, Frailty Syndrome
- Trial name
- GERAS DANCE (NCT06870149)
- Testing
- Dance Rehabilitation Intervention
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- McMaster University
Frail Elderly Syndrome
Protocols and Guidelines for the Use of Digital Twins in Frail Older People
The Proto-Aging study aims to define experimental protocols and guidelines to enable the development of musculoskeletal models (digital twins) of elderly people, with the ultimate goal to comprehensively characterize frail elders…
- Trial name
- Proto-Aging (NCT05854316)
- Testing
- Comprehensive Biomechanical assessment
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli