Clinical trials: Frail
Coronary Artery Bypass Grafting, Heart Valve Replacement
A Prehabilitation Program for Frail Patients Undergoing Cardiac Surgeries/Procedures
The purpose of this study is to develop and evaluate a frailty-specific prehabilitation program for patients awaiting cardiac surgeries/procedures.
- Conditions
- Coronary Artery Bypass Grafting, Heart Valve Replacement, Transcatheter Aortic Valve Implantation, Frailty
- Trial name
- PREHAB (NCT06323317)
- Testing
- Multi-component exercise programme, Structured preoperative education, Nutritional optimization
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Osteoporosis
Qualitative Study Exploring the Determinants Involved in the Management of Osteoporosis in Frail Elderly People
The aging population is associated with an increase in the number of elderly people as well as in chronic diseases, particularly osteoporosis and its fracture consequences, which lead to a decline in quality of life and life…
- Trial name
- QualiFichOs (NCT07303166)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Strasbourg, France
Breast Cancer
Adjuvant Chemotherapy for Elderly Non Frail Patients With an Increased Risk for Relapse of a Primary Carcinoma of the Breast
Although approximately 50% of new diagnosis breast cancers are in patients above the age of 65, elderly people remain substantially under-represented in clinical trials, and therefore are under-treated.
- Trial name
- ICE-II (NCT01204437)
- Testing
- Epirubicin, Cyclophosphamide, Cyclophosphamide, Methotrexate, 5 FU, Capecitabine, Nab-Paclitaxel
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- GBG Forschungs GmbH
Frail Elderly Syndrome, Patient Admission
Geriatric Assessment and Intervention for Older Patients With Frailty in the Emergency Department
Comprehensive Geriatric Assessment (CGA) is an established approach for better detection of frailty-related problems and includes individualized treatment plan with multi-discipline supportive and treating measures for the older…
- Conditions
- Frail Elderly Syndrome, Patient Admission, Hospital Readmission, Length of Stay
- Trial name
- GAOPS (NCT03751319)
- Testing
- CGA
- Where
- Finland
- Volunteers
- 432 people
- Sponsor
- Helsinki University Central Hospital
Hypotension on Induction, Frailty
EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery
Post-induction hypotension (PIH) is a common and clinically significant hemodynamic complication following general anesthesia induction.
- Conditions
- Hypotension on Induction, Frailty, Anesthesia, General
- Trial name
- PIXEL (NCT07642765)
- Testing
- EASIX Score Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Konya City Hospital
Coronary Artery Bypass Graft (CABG)
Investigation of the Effect of Prehabilitation Practice on Patient Outcomes in Frail Patients Planned for Elective Coronary Artery Bypass Graft
The basic concept of prehabilitation is to increase the functional capacity of the individual to withstand an expected injury. It embodies the idea of being proactive against the common reactive approach of rehabilitation.
- Trial name
- ERAS (NCT07138534)
- Testing
- prehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bahçeşehir University
Diffuse Large B-Cell Lymphoma
Glofitamab, Polatuzumab Vedotin and Zanubrutinib in First-line Elderly DLBCL
This study aims to assess the efficacy and safety of the chemotherapy-light combination of glofitamab, polatuzumab vedotin and zanubrutinib (GPZ) in elderly patients with previously untreated diffuse large B-cell lymphoma.
- Trial name
- NCT07012980
- Testing
- Glofitamab, Polatuzumab Vedotin, Zanubrutinib
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Shanghai Zhongshan Hospital
End Stage Renal Failure on Dialysis, Frail Elderly Syndrome
The Effect of Intradialytic Exercise on the Physical Function of People Undergoing Hemodialysis
The investigators intend to recruit 50 patients into an intradialytic exercise study that will measure the impact of resistance bands exercises under the guidance of an exercise physiologist on the physical function of…
- Trial name
- IDEX (NCT03944824)
- Testing
- Exercise Plan using resistance bands, Modified Fried Frailty Scale
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Satellite Healthcare
Accidental Falls
The HIP-HOP Flooring Study: Helping Injury Prevention in Hospitalised Older People
In hospitals, older people can fall and hurt themselves. The investigators want to see if a new type of flooring can help stop people hurting themselves as badly, if they accidentally fall.
- Trial name
- NCT00817869
- Testing
- New flooring
- Where
- 8 sites in United Kingdom
- Volunteers
- 571 people
- Sponsor
- University of Portsmouth
Frailty Syndrome
Clinical Intervention in Frail Older People (FRAILCLINIC)
Frailty is the main risk factor for the development of incident disability in older people and one of the most important for other adverse outcomes (death, hospitalisation, falls, and permanent institutionalisation).
- Trial name
- FRAILCLINIC (NCT02643069)
- Testing
- Intervention Geriatric Program
- Where
- Spain
- Volunteers
- 821 people
- Sponsor
- Hospital Universitario Getafe
Biliary Tract Infection
Ultrasound-guided Biliary Drainage Improving Prognosis in the Frail and High Risk Elderly Patients
Acute biliary tract infection is a kind of disease caused by bacteria of biliary tract infection, mainly including acute cholecystitis and acute cholangitis, especially acute obstructive suppurative cholangitis (AOSC),which can…
- Trial name
- NCT06960486
- Testing
- Bedside ultrasound-guided real-time biliary drainage, traditional appointment ultrasound
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hebei Medical University
Untreated Chronic Lymphocytic Leukemia
STop and Restart Acalabrutinib In fRail Patients With Previously Untreated Chronic Lymphocytic Leukemia
The irreversible Bruton's Tyrosine Kinase (BTK) inhibitor acalabrutinib (ACA) has potent clinical activity as a single agent in patients with treatment naive and Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL).
- Trial name
- STAIR (NCT04963946)
- Testing
- Stop ACA, ACA Continuation
- Where
- 32 sites in France
- Volunteers
- 160 people
- Sponsor
- French Innovative Leukemia Organisation
Surgery, Physical Activity
Understanding Pre-operative Activity Levels in Elderly Patients
The investigators aim to determine whether a wrist-worn accelerometer device is able to objectively measure physical activity, and whether it is an acceptable process for high-risk elderly patients prior to planned surgery.
- Conditions
- Surgery, Physical Activity, Aging
- Trial name
- NCT03737903
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Joanne Outtrim
Aging
SArcopenia Prevalence in Frail Older Adults. SAF Study
The age-associated loss of lean mass is a defining parameter of sarcopenia and may lead to various negative health outcomes such as impairment of physical performance and disability.
- Trial name
- SAF (NCT02903992)
- Testing
- Dual-energy X-ray absorptiometry (DXA)
- Where
- France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Toulouse
DLBCL, Diffuse Large B Cell Lymphoma
A Randomized, Multicenter, Phase III Trial Comparing Treatment With R-mini-CHOP With R-mini-CHP + Polatuzumab Vedotin in Patients With Diffuse Large Cell B Cell Lymphoma
This is a phase III, randomized, open-label, multicenter trial, conducted in Sweden, Norway, Finland, Denmark, Italy, Australia and New Zealand, in elderly patients with untreated diffuse large B-cell lymphoma.
- Trial name
- POLAR BEAR (NCT04332822)
- Testing
- R-pola-mini-CHP, R-mini-CHOP
- Where
- 69 sites in Australia, Denmark and 5 more
- Volunteers
- 300 people
- Sponsor
- Nordic Lymphoma Group
Frail Elderly, Malnutrition
Healthy Life for Frail Malnourished Seniors Performed Together With Trained Lay Buddies
Background: In elderly subjects frailty and malnutrition are very common and can lead to serious health hazards, increase mortality, morbidity, dependency, institutionalization and a reduced quality of life.
- Trial name
- NCT01991639
- Testing
- Nutritional and physical activity intervention
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Angina, Stable, Congestive Heart Failure
Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA
This feasibility trial will focus on older adults 60+ who are candidates for cardiac or pulmonary rehabilitation and who are vulnerable, mildly or moderately frail.
- Conditions
- Angina, Stable, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05562037
- Testing
- Stepped Care
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- Peter Lindenauer, MD
Dental Prosthesis Failure, Frail Elderly Syndrome
Immediate Dental Prosthesis Functionalization Protocol in People Over 70 Years of Age
Sarcopenia and malnutrition are closely involved in frailty. To prevent them, it is essential to assess oral function. "Oral fragility" manifests with specific signs or symptoms, including occlusion loss due to tooth loss and…
- Trial name
- NCT05818436
- Testing
- Procedure: prosthetic functioning, Conventional dental prosthesis
- Where
- Chile
- Volunteers
- 124 people
- Sponsor
- University of Chile
Pre-frail Elderly
Effects of Combined Motor and Cognitive Training in Pre-frail Elderly
The objective of this study is to investigate psychometric properties of dual-task walking assessments and compare effects of combined motor and cognitive training on physical fitness, brain fitness, and dual-task walking…
- Trial name
- NCT04605809
- Testing
- combined motor and cognitive training, motor training alone, cognitive training alone
- Where
- Taiwan
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Vaccination Uptake
Caring for Frail Patients Through Vaccination
The CareVax project aims to find frail patients at Fondazione Policlinico Universitario 'A. Gemelli' IRCCS who could benefit from vaccinations against pneumococcal, Zoster, flu, HBV and SARS-CoV-2.
- Trial name
- CAREVAX (NCT06127563)
- Testing
- creation of a clinical pathway to increase vaccination coverage in frail patients
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS