Clinical trials: Frail Elderly
RSV Immunisation
RSV Immunogenicity Study in the Elderly (RISE)
Respiratory syncytial virus (RSV) is a common cause of respiratory tract infections leading to hospitalizations in infants and in elderly.
- Trial name
- RISE (NCT07203365)
- Testing
- This study examines immune response differences Arexvy between individuals aged 80+ and adults aged 60-65
- Where
- 2 sites in Sweden
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Karin Karin Loré
Diabetes Mellitus
DiaFrail: A Short Duration Study in Older People ( DIAFRAIL Study)
1. Many patients with type 2 diabetes are not at glycaemic goal and require additional therapy in order to reduce vascular risk and improve symptom control 2.
- Trial name
- DiaFrail (NCT02484209)
- Testing
- Metformin, Glimepiride
- Sponsor
- Diabetes Frail Ltd
Heart Failure, Frailty
INTEgRated Health CARE for Patients With Frailty and Heart Failure
Frailty, an aging-related syndrome of physiological decline characterized by marked vulnerability to adverse health outcomes, has attracted increasing attention in cardiology due to the growing elderly population with heart…
- Conditions
- Heart Failure, Frailty, Frail Elderly Syndrome, Symptom, Behavioral
- Trial name
- INTERCARE-HF (NCT06444321)
- Testing
- INTERCARE-HF
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Vestre Viken Hospital Trust
Ictus, Convalescence
Effectiveness of Laser Visual Feedback in Postural Control After a Stroke
Background: Stroke is one of the leading causes of acquired disability and frequently results in impairments in balance and postural control that affect functional independence.
- Conditions
- Ictus, Convalescence, Rehabilitation by Recovery of Function, Rehabilitation Frail Elderly Subjects
- Trial name
- FV-CP (NCT07811843)
- Testing
- Intervention
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Parc Sanitari Pere Virgili
Hip Osteoarthritis, Knee Osteoarthritis
Fit-Joints: Getting Fit for Hip or Knee Replacement
Osteoarthritis leads to reduced independence and quality of life. Total hip replacement is a successful and cost-effective surgical intervention to relieve pain and improve functioning in patients with osteoarthritis.
- Trial name
- Fit-Joints (NCT02885337)
- Testing
- Multi-Modal Frailty Intervention, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- McMaster University
Frailty, Frailty Syndrome
Characterising Frailty Using Magnetic Resonance Imaging
Ageing is associated with the development of various negative conditions, such as frailty. Defined as a decreased ability to combat negative stressors (e.g.
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome
- Trial name
- PHENOFRIM (NCT04612686)
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Decision Process About the Location of Care Among Frail Elderly
Improving Decision Making On Location of Care With the Frail Elderly and Their Caregivers
One of the toughest decisions faced by the frail elderly in Canada is whether to stay at home or move to a care facility. It is certainly difficult to make this decision alone, but can be even harder if someone else makes it for…
- Trial name
- DOLCE (NCT02244359)
- Testing
- Training, Usual care
- Where
- Canada
- Volunteers
- 455 people
- Sponsor
- CHU de Quebec-Universite Laval
Frailty, Caregiver Burden
The Effect of Health Promotion Comprehensive Education Intervention on the Frailty Levels of Elderly Family Caregivers
This study was conducted to evaluate the effect of a comprehensive health promotion educational intervention applied to family caregivers over the age of 60 on their fragility levels.
- Conditions
- Frailty, Caregiver Burden, Frail Elderly Syndrome
- Trial name
- NCT06064227
- Testing
- training intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Fatma Banu Demirdas
Atrial Fibrillation (AF), Stroke
Catheter Ablation Plus LAAO Versus Anticoagulation in Frail Elderly Patients With Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia, significantly increasing the risk of stroke, heart failure, hospitalization and death in patients.
- Conditions
- Atrial Fibrillation (AF), Stroke, Hemorrhage, Frailty
- Trial name
- CLEAR-AF (NCT07441382)
- Testing
- catheter ablation combined with LAAO (Left Atrial Appendage Occlusion), Atrial Fibrillation Radiofrequency Ablation Only
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guangdong Provincial People's Hospital
Lupus Erythematosus, Systemic
Osteoporosis and Fragility Fractures Among SLE Patients. (FRAIL Trial)
The trial is designed to evaluate prevalence of fragility fracture, their impact on quality of life of SLE patients and disease or treatment variables such as steroids dosage or use of specific drugs like hydroxychloroquine…
- Trial name
- FRAIL (NCT05590390)
- Testing
- DXA, serum sample, PROs
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Frail Elderly Syndrome
Effectiveness of a Socio-Community Health Intervention on Pre-Frailty in Older Adults
The objective of this study is: To evaluate the effectiveness of a health intervention with a socio-community approach on frailty in older adults with pre-frailty.
- Trial name
- NCT06663150
- Testing
- health intervention with a socio-community approach
- Where
- Colombia
- Volunteers
- 160 people
- Sponsor
- Keralty SAS. Colombia
Postoperative Delirium
Factors Affecting the Incidence of Postoperative Delirium in Frail Elderly
Postoperative delirium has been found to be associated with increased risk of future neurocognitive decline and mortality especially in elderly patients.
- Trial name
- NCT02227225
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Frail Elderly Syndrome
Management of Frailty in Older Adults With Turmeric and Tulsi Supplements
The aim of this study is to determine the efficacy of turmeric and tulsi polyherbal formulation in the management of frailty in the elderly population.
- Trial name
- NCT03365310
- Testing
- C. longa, curcuminoids , Z. officianale, O. sanctum along with 200 ml of Milk, Standard of Care
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Composite Interceptive Med Science
Heart Failure
Effects of a Wed-based FRAIL-SM Program Among Patients With Heart Failure
This study aims to examine the effects of web-based FRAIL-SM (Family involvement, self-Regulation skills training, Autonomy, Information sharing and Linkage, Self-Management) on frailty, self-management behaviors and quality of…
- Trial name
- NCT07068308
- Testing
- web-based FRAIL-SM program
- Where
- Taiwan
- Volunteers
- 328 people
- Sponsor
- National Yang Ming Chiao Tung University
Frail Older Adults
Healthy Living Programme for Older Adults
Malnutrition, risk of falls and medication incidents are commonly faced by the older adults. This study aimed to provide health education to community-dwelling older adults and to assess the effectiveness of a Healthy Living…
- Trial name
- HLP (NCT02904174)
- Testing
- Healthy Living Programme
- Volunteers
- 122 people
- Sponsor
- The Hong Kong Polytechnic University
Frail Elderly, Patient Care
Geriatric Education and Its Effect on Certain Aspects of Hospital Care of Nursing Home Patients
Nursing home patients admitted to the hospital pose a significant challenge for health care providers. Geriatric teaching pays particular attention to these admissions and related problems.
- Trial name
- NCT00384709
- Sponsor
- Maimonides Medical Center
Ischemic Stroke, TIA
Statins in Frail Older Patients with Ischemic Stroke or Transient Ischemic Attack - the Prospective Cohort Study
Two Dutch guidelines (Stroke and Cardiovascular Risk Management) provide conflicting advice on optimal statin treatment in older patients.
- Trial name
- SAFEST-coh (NCT06785740)
- Testing
- Statin
- Where
- 4 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Healthy Ageing, Frailty
An Intrinsic Capacity Identification and Management Programme for Older Adults in Singapore's Primary Care
The IMPACTFrail program is an intrinsic capacity (IC) identification and management program for mildly frail older adults. Specifically, it delivers the three-tier approach recommended in the National Frailty Strategy Policy…
- Trial name
- IMPACTFrail (NCT06753643)
- Testing
- The IMPACTFrail programme
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Geriatric Education and Research Institute
HIV, Inflammation
Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause
The primary objective of this proposal is to compare a moderate or high intensity exercise intervention to improve physical function in persons aging with Human Immunodeficiency Virus (HIV).
- Conditions
- HIV, Inflammation, Obesity, Aging, Biological
- Trial name
- NCT02404792
- Testing
- High-intensity cardiovascular and resistance exercise, Moderate-intensity cardiovascular and resistance exercise
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiovascular-kidney-metabolic Syndrome
Mechanisms and Interventions for Physical Activity in Frail Cardiovascular-kidney-metabolic Syndrome Patients: A Temporal Self-Regulation Approach
Longitudinal physical activity data and associated factors were collected at baseline (diagnosis), 3-month, 6-month, and 9-month follow-ups in cardiovascular-kidney-metabolic syndrome patients.
- Trial name
- CKM (NCT07131488)
- Volunteers
- 614 people
- Sponsor
- Nanjing Medical University