Clinical trials: Frail Elderly
Aging, Frailty
Cognitive-Motor Exergame Training in Frail Adults
This international multicentre pragmatic randomized controlled trial (RCT) aims to evaluate the effectiveness of personalized, home-based cognitive-motor training using exergames in improving cognitive and motor functions in…
- Trial name
- SMART (NCT07074639)
- Testing
- Personalized, home-based motor-cognitive exergame training, Otago Exercise Program
- Where
- Switzerland
- Volunteers
- 344 people
- Sponsor
- Eleftheria Giannouli
Parkinson Disease, Frail Elderly
Innovative Models in the Rehabilitation of the Elderly With Parkinson's Disease Through Technological Innovation
The final goal of the present study is to propose a new approach in the Parkinson's Disease rehabilitation, focused on the use of robotic devices and to check the results not only at the end of the treatment but also in the long…
- Conditions
- Parkinson Disease, Frail Elderly, Robotic Devices in Rehabilitation
- Trial name
- NCT04087031
- Testing
- control arm, virtual reality games, robotic treadmill
- Where
- 2 sites in Italy
- Volunteers
- 195 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Frail Elderly Syndrome, Major Surgery
Multimodal Prehabilitation for Surgery in the Elderly: a Randomised, Prospective, Multicenter, Multidisciplinary Trial
This multicentric, randomised controlled trial is to the investigators knowledge the first implementation of a multimodal, multidisciplinary prehabilitation approach using knowledge from different specialties to lower…
- Trial name
- PREHABIL (NCT04461301)
- Testing
- Multimodal Prehabilitation
- Where
- Switzerland
- Volunteers
- 466 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pre-Frail Older Adults
Pharyngeal Exercise (Plus Protein)
The swallowing muscles are prone to decreased strength and function as part of the natural aging process which can lead to difficulty swallowing, malnutrition, and frailty.
- Trial name
- PE(PP) (NCT05963113)
- Testing
- Pharyngeal Swallowing Exercises, Protein Supplementation, MRI
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Accidental Falls
Trial to Reduce Falls Incidence Rate in Frail Elderly
Background: Approximately 750,000 elderly Dutch people fall at least once a year, which often results in physical injuries and a fear of falling, with high costs and far-reaching consequences on functionality, physical activity…
- Trial name
- CP (NCT00512655)
- Testing
- Fall prevention course
- Where
- 3 sites in Netherlands
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Physical Activity
Training Intervention in a Controlled Population of Frail Elderly
Exercise has a beneficial role in geriatric patients categorized as frail. Nevertheless, it is not known physical training pattern more beneficial for these patients.
- Trial name
- EMTIFE (NCT02331459)
- Testing
- Multicomponent training intervention, Nutritional intervention
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital de la Ribera
Polytrauma, Red Blood Cell Distribution Width
Red Blood Cell Distribution Width and Charlson Comorbidity Indeces in the Frail Polytraumatized Patient.
In this study patients who were admitted to our hospital with critical injuries were enrolled retrospectively from January 2012 to December 2015.
- Conditions
- Polytrauma, Red Blood Cell Distribution Width, Comorbidities and Coexisting Conditions
- Trial name
- NCT05221476
- Testing
- retrospective
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Hip Fractures, Anesthesia
Fractional Spinal Anesthesia and Systemic Hemodynamics in Frail Elderly Hip Fracture Patients.
Aging and frailty make the elderly patients susceptible to hypotension following spinal anaesthesia. The systemic haemodynamic effects of spinal anaesthesia are not well known.
- Conditions
- Hip Fractures, Anesthesia, Hypotension Drug-Induced, Cardiac Output, Low
- Trial name
- NCT05101291
- Testing
- Bupivacain
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Sahlgrenska University Hospital
Hip Fractures
Conventional Spinal Anaesthesia Versus Fractional Spinal Anaesthesia on Hemodynamics
compare the systemic haemodynamic response to fractional spinal anaesthesia versus conventional spinal anaesthesia , in a group of elderly and comorbid patients with hip fracture.
- Trial name
- NCT06583213
- Testing
- Fractional Spinal Anaesthesia., Conventional Spinal Anaesthesia
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Ain Shams University
Frail Older Adults
Effectiveness of a Comprehensive Patient-centered Hospital Discharge Planning Intervention for Frail Older Adults
A large number of frail older adults have difficulty performing activities of daily living and resuming former roles in the months following hospital discharge.
- Trial name
- HOME (NCT04154917)
- Testing
- HOME
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Université de Sherbrooke
Equilibration Disorder, Vestibular Nerve
Application of Whole-body Vibration With Stochastic Resonance in Frail Elderly: The Effects on Postural Control
This study aims to examine 1. the feasibility 2. immediately 3. long term effects on postural control and strength of mechanical SR-WBV intervention in a frail elderly population.
- Trial name
- NCT01543243
- Testing
- Stochastic resonance whole-body vibration A, Stochastic resonance whole-body vibration B
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Bern University of Applied Sciences
Malnutrition, Sarcopenia
Evaluation of an Oral Nutritional Supplement Containing AN777
To evaluate the effect of an experimental oral nutritional supplement containing AN777 compared to another oral nutritional supplement in a malnourished, elderly population.
- Trial name
- NCT01191125
- Testing
- medical food with AN777, oral nutritional formula
- Where
- 23 sites in United States, Belgium and 6 more
- Volunteers
- 331 people
- Sponsor
- Abbott Nutrition
Sarcopenia
Feasibility of a Resistance Exercise and Dietary Protein Intervention in Elderly People in Practice (ProMuscle 65PK)
The purpose of this pilot study is to investigate the feasibility and potential impact of a combined resistance exercise and increased protein intake intervention in (frail) elderly, in a real-life setting.
- Trial name
- NCT02434289
- Testing
- Dietary protein products, Resistance exercise training
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Wageningen University
Frail Elderly, Fall Risk
Functional Changes and Fall Risk in Older Adults Participating in a Frailty Program
This prospective observational study aims to describe changes in physical function and fall risk in adults aged 70 years and older participating in a routine multicomponent frailty and falls prevention program in primary care.
- Trial name
- FRAIL-ALAMA (NCT07572851)
- Testing
- Multicomponent Exercise Program- 1 times per week., Multicomponent Exercise Program- 2 times per week.
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- University of Vigo
Frail Elderly Syndrome
Multifactorial Fall Prevention Program
The main objective is evaluate the effectiveness of a Multifactorial Pilot Program on the Prevention of Falls in people aged 65 or over during 4 years at Gerencia de Atención Integrada de Talavera de la Reina.
- Trial name
- Dodgers (NCT05682872)
- Testing
- Physical exercise program (VIVIFRAIL) supervised by a physiotherapist, Adequacy of the environment, Polypharmacy review
- Where
- Spain
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Castilla-La Mancha Health Service
Pre-frail, Pre-Frail Older Adults
The Impact of Whey Protein on Frailty in Older Adults Classified as Pre-frail
This pilot study aims to determine the impact of whey protein supplementation on brain antioxidant levels and to assess the effects of whey protein supplementation on physical function, body composition, and cognition in…
- Conditions
- Pre-frail, Pre-Frail Older Adults, Cognition, Physical Function
- Trial name
- NCT07167277
- Testing
- Whey Protein
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Glioma, Glioblastoma
Phase II Elderly/Frail Pts With Newly Diagnosed or Recurrent Malignant Glioma Treated With Cesium-131 GammaTile®
This is a phase 2, open-label clinical trial determining feasibility, safety, and tolerability of GammaTile® in elderly or frail subjects with newly diagnosed or recurrent malignant gliomas.
- Conditions
- Glioma, Glioblastoma, GBM, Glioma, Malignant
- Trial name
- ENDURANCE (NCT07821112)
- Testing
- GammaTile®
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Sarcopenia, Aged
HIT Training in the Frail Elderly.
This pilot study aims to investigate whether high intensity interval training can result in rapid improvements in physical fitness amongst the frail elderly (over 70 years old).
- Conditions
- Sarcopenia, Aged, Exercise, Preoperative Care
- Trial name
- eHIT (NCT03138265)
- Testing
- HIIT Device: ergometer
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Diffuse Large B Cell Non-Hodgkin Lymphoma
A Combination of Rituximab and CC-99282 as Front-line Therapy for Older Frail Patients With Diffuse Large B-cells Non-Hodgkin Lymphoma Evaluated With a Simplified Geriatric Assessment (sGA): a Phase II Study of the Fondazione Italiana Linfomi (FIL)
Prospective, multicenter, single arm, phase II study, to evaluate the efficacy of the combination rituximab-golcadomide as a chemo free approach in a population of older patients with new diagnosis of DLBCL, defined as frail…
- Trial name
- FIL_RICCO (NCT06835530)
- Testing
- Rituximab + Golcadomide (CC-99282)
- Where
- 20 sites in Italy
- Volunteers
- 47 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Frail Elderly Syndrome
Protocols and Guidelines for the Use of Digital Twins in Frail Older People
The Proto-Aging study aims to define experimental protocols and guidelines to enable the development of musculoskeletal models (digital twins) of elderly people, with the ultimate goal to comprehensively characterize frail elders…
- Trial name
- Proto-Aging (NCT05854316)
- Testing
- Comprehensive Biomechanical assessment
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli