Clinical trials: Frail Elderly Patients
Postoperative Delirium, Cognitive Function Abnormal
EEG Characteristics and Postoperative Delirium
The goal of this [type of study: observational study ] is to [compare Energy differences in various bands of intraoperative electroencephalogram in elderly patients with postoperative delirium and non delirium.] in [describe…
- Conditions
- Postoperative Delirium, Cognitive Function Abnormal, PSI, Frailty
- Trial name
- NCT06102967
- Testing
- delirium
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhuo Liu
Frail Elderly Syndrome
Frailty and Surgery
Frailty has been recently re-defined as a condition that is evident over time through an excess of vulnerability to stressors, with reduced ability to maintain or regain homeostasis after a destabilizing event, and occurrence of…
- Trial name
- NCT05594277
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Rheumatic Arthritis
Intervention to Support Partners and Informal Caregivers of Frail RA-patients
Background Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with pain, fatigue, functional limitations, and reduced quality of life.
- Trial name
- INSPIRE (NCT07442773)
- Testing
- Caregiver support
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Frail Elderly Syndrome, Patient Admission
Geriatric Assessment and Intervention for Older Patients With Frailty in the Emergency Department
Comprehensive Geriatric Assessment (CGA) is an established approach for better detection of frailty-related problems and includes individualized treatment plan with multi-discipline supportive and treating measures for the older…
- Conditions
- Frail Elderly Syndrome, Patient Admission, Hospital Readmission, Length of Stay
- Trial name
- GAOPS (NCT03751319)
- Testing
- CGA
- Where
- Finland
- Volunteers
- 432 people
- Sponsor
- Helsinki University Central Hospital
Hip Osteoarthritis, Knee Osteoarthritis
FitJoints: Getting Fit for Hip and Knee Replacement
Total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis.
- Trial name
- NCT05100966
- Testing
- FitJoints Multi-modal Intervention
- Where
- 4 sites in Canada
- Volunteers
- 192 people
- Sponsor
- McMaster University
Diffuse Large B-Cell Lymphoma
The Efficacy and Safety of Pola-ZR2 Versus ZR2 in the Treatment of Old Patients With de Novo Diffuse Large B-cell Lymphoma
A multicenter, prospective, randomized, open-label, controlled trial to evaluate the efficacy and safety of Pola-ZR2 (polatuzumab vedotin, zanubrutinib, rituximab and lenalidomide) versus ZR2 (zanubrutinib, rituximab and…
- Trial name
- NCT06522555
- Testing
- polatuzumab vedotin, zanubrutinib, rituximab and lenalidomide, zanubrutinib, rituximab and lenalidomide
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ruijin Hospital
COVID, Social Isolation
First Level Socio-geriatric Evaluation: ESOGER Databank
Coronavirus disease 2019 (COVID-19) is an infectious disease. Physical distancing is one of the most effective ways to reduce the spread of COVID-19, but this key prevention intervention may have adverse consequences on older…
- Conditions
- COVID, Social Isolation, Anxiety, Frailty
- Trial name
- NCT04393649
- Testing
- ESOGER
- Where
- Canada
- Volunteers
- 20,000 people
- Sponsor
- Jewish General Hospital
Frail Elderly
Unsupervised Elastic Band Exercises Performed by Frail Elderly Hospitalized Patients Monitored by the Bandcizer
This feasibility study investigates if frail elderly and hospitalized patients are able to perform unsupervised elastic band exercises as a supplement to their usual supervised physiotherapy sessions and how much training they…
- Trial name
- NCT02702557
- Testing
- Elastic Band Exercises
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Aalborg University Hospital
HIV Infections, Frail Older Adults
Spanish Cohort of Patients with HIV Infection Older Than 50 Years for the Study of Fragility and Physical Function
It's a prospective observational study to assess frailty and physical function
- Trial name
- FUNCFRAIL (NCT03558438)
- Testing
- No interventions
- Where
- 13 sites in Spain
- Volunteers
- 802 people
- Sponsor
- Fundacion SEIMC-GESIDA
Coronary Artery Bypass Graft
Prehabilitation and Coronary Artery Bypass Grafting
To evaluate the effects of Prehabilitation Resistance training on frailty and functional capacity in mild to moderate clinically frail patients awaiting Coronary Artery Bypass Grafting) CABG.
- Trial name
- NCT04993976
- Testing
- Resistant training (Prehabilitation), Active Comparator: Control group
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Functionality, Fragility
IMPACT OF A MULTICOMPONENT PHYSICAL EXERCISE PROGRAM ON THE FUNCTIONAL CAPACITY OF PATIENTS ADMITTED TO AN INTERMEDIATE CARE HOSPITAL. VIVIFRAIL FOR A BETTER VIG-FRAIL.
INTRODUCTION Physical exercise in frail individuals has demonstrated benefits in variables such as reduced mortality risk and improved frailty and quality of life.
- Trial name
- NCT07637383
- Testing
- vivifrail
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Inpatients, Frail
Effect of Using a Reminder to Encourage Patients to be Active During Their Hospital Stay.
Around 30% of patients aged 65 and over experience functional decline due to hospitalization. Physical inactivity, often without medical justification, is common during hospital stays.This immobility leads to loss of autonomy…
- Trial name
- REMOTIVE (NCT07492745)
- Testing
- Vibrating reminder, Control group
- Where
- 4 sites in Belgium, France
- Volunteers
- 204 people
- Sponsor
- Groupe Hospitalier du Havre
Physiological Reactivity to Cues, Physical Exercise
Pilot Study to Evaluate Targeted Physical Activity Among Pancreatic Cancer Patients Receiving Neoadjuvant Chemotherapy
Patients with pancreatic cancer receiving neoadjuvant chemotherapy often experience functional decline, treatment interruptions, and clinical deterioration, and these risks may be amplified when frailty is present.
- Trial name
- GI-07 (NCT07647250)
- Testing
- 36-session targeted physical exercise program delivered twice weekly
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Illinois Chicago
Biliary Tract Diseases, Procedural Sedation and Analgesia
Esketamine Versus Sufentanil for Sedation in Patients Undergoing ERCP
This study compares two anesthesia medications, esketamine and sufentanil, used together with propofol during ERCP procedures. The goal is to find out which combination provides better safety and comfort for people undergoing…
- Trial name
- ES-ERCP (NCT07702240)
- Testing
- Esketamine, Sufentanil
- Volunteers
- 530 people
- Sponsor
- Ren Da
Gastric Cancer, Immunotherapy
Anlotinib Plus Toripalimab as First-line Treatment for Advanced Gastric Cancer With ECOG 2 (APICAL-GC)
This study is designed to evaluate the efficacy and safety of the combination of Anlotinib wiht Toripalimab in advanced gastric cancer with ECOG 2 as first-line regimen.
- Conditions
- Gastric Cancer, Immunotherapy, Anlotinib, Toripalimab
- Trial name
- NCT04278222
- Testing
- Anlotinib Plus Toripalimab
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai Changzheng Hospital
Diffuse Large B Cell Lymphoma
Polatuzumab, Rituximab and Orelabrutinib Combination Regimen (PRO) in the Treatment of Elderly Frail Patients with Treatment-naive Non-GCB DLBCL
This prospective, single-arm, multicenter clinical study aims to enroll 30 frail elderly patients with Non-GCB DLBCL. This study is to evaluate the preliminary efficacy and safety of the combination of Polatuzumab, Rituximab, and…
- Trial name
- NCT06530511
- Testing
- Polatuzumab vedotin, Rituximab, Orelabrutinib
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Nantong University
COVID-19, Solid Tumor
National Project on Vaccines, COVID-19 and Frail Patients
This is a multicentre observational study with the aim of evaluating the antibody and cellular response after vaccination for SARS-CoV-2 with Pfizer-BioNTech or Moderna vaccines in frail subjects with impaired immuno-competence…
- Conditions
- COVID-19, Solid Tumor, Hematologic Diseases, Neurologic Disorder
- Trial name
- VAX4FRAIL (NCT04848493)
- Testing
- COVID-19 vaccines
- Where
- 12 sites in Italy
- Volunteers
- 747 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Frailty, Frail Elderly Syndrome
Education for Prevention and Treatment of Frailty
Frailty is a condition with a high prevalence in older adults, leading to higher vulnerability and increasing the risk of adverse health outcomes and disabilities.
- Trial name
- FRAGSALUD (NCT05610605)
- Testing
- Health intervention programme: FRAGSALUD
- Where
- Spain
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Intraoperative Hypotension
Hypotension Prediction Index and Intraoperative Hypotension Incidence
This study aim to implement intraoperative hemodynamic monitoring and management guided with HPI algorithm in frail patients undergoing elective abdominal surgery.
- Trial name
- NCT06909786
- Testing
- HPI guided hemodynamic management, standard arterial line
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Transplant-Related Disorder, Frail Elderly Syndrome
Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients
The objective of this study is to assess the feasibility and effectiveness of dedicated ambulator-assisted physical activity in lung transplant inpatients.
- Conditions
- Transplant-Related Disorder, Frail Elderly Syndrome, Sarcopenia, Lung Graft Dysfunction
- Trial name
- iFRAIL (NCT03636412)
- Testing
- Ambulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic