Clinical trials: Frail Older Adults
Renal Dialysis, Kidney Failure, Chronic
Quality of Life of Frail Aged Patients in Incremental Hemodialysis
End stage renal disease (ESRD) is a major public health problem. The dialysis population is aging. As a result we observe a high prevalence of frailty among dialysis patients (ranges from 3 to 10 fold higher than in the…
- Conditions
- Renal Dialysis, Kidney Failure, Chronic, Frailty
- Trial name
- Qualifragilys (NCT03782519)
- Testing
- Dialysis frequency reduction, Frailty diagnosis
- Where
- France
- Volunteers
- 783 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Elderly Infection, Frailty
Antibiotic Dosing in Geriatric Patients At the Emergency Department
In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate…
- Conditions
- Elderly Infection, Frailty, Frail Elderly Syndrome, Infection, Bacterial
- Trial name
- AGED (NCT04436991)
- Testing
- Blood sampling, Sputum sample, Hemoculture
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- University Hospital, Ghent
Frail Elderly Syndrome
Implementing, Evaluating, and Scaling Up of the Strengthening a Palliative Approach in Long Term Care (SPA-LTC) Program
This study will evaluate the implementation of the Strengthening a Palliative Approach in Long-Term Care (SPA-LTC) program using a cross-jurisdictional, effectiveness-implementation type II hybrid design (dual testing of clinical…
- Trial name
- NCT03935997
- Testing
- Strengthening a Palliative Approach in Long-Term Care (SPA-LTC) Program
- Where
- 4 sites in Canada
- Volunteers
- 594 people
- Sponsor
- McMaster University
Transitional Care, Frail Elderly
Making Health Care Safer for Older Adults Receiving Skilled Home Health Care Services After Hospital Discharge
Care transitions are the movement of a person from one healthcare setting to another. Older adults who require skilled home health care ("home health") services (e.g., home-based nursing) after hospital discharge are at high risk…
- Conditions
- Transitional Care, Frail Elderly, Home Health Care
- Trial name
- NCT05182060
- Testing
- Transition Intervention
- Where
- United States
- Volunteers
- 761 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Activities of Daily Living
Digital Solutions for Elderly Care by Informal Caregivers
The study aims to determine the benefits of a web-based documentation and advice for elderly people and their caregivers. It is a randomized controlled trial with two arms (intervention, control).
- Trial name
- DigiSECC (NCT06199648)
- Testing
- web-based documentation and advice
- Where
- Austria
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences for Health Professions Upper Austria
Frail Elderly Syndrome
Screening of the Frailty Degree in the Emergency Department Short Stay Unit
Screen all those> 65 years of age admitted to the Short Stay Unit for frailty, and detect those who are potentially fragile.
- Trial name
- NCT04812834
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Elderly People
Immune Benefits of WGP in Elderly
The aim of this research is to assess the immune enhancing property of food fibers in the elderly population.
- Trial name
- NCT02262091
- Testing
- Food fibers, Maltodextrin, Influenza vaccine (incl. criterion)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Société des Produits Nestlé (SPN)
HIV, Inflammation
Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause
The primary objective of this proposal is to compare a moderate or high intensity exercise intervention to improve physical function in persons aging with Human Immunodeficiency Virus (HIV).
- Conditions
- HIV, Inflammation, Obesity, Aging, Biological
- Trial name
- NCT02404792
- Testing
- High-intensity cardiovascular and resistance exercise, Moderate-intensity cardiovascular and resistance exercise
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Frailty
Prevention of Disability in the Frail Elderly Person Through an Innovative Customised and Multidimensional Training Programme
The goal of this clinical trial is to implement a personalized training program to prevent functional decline in frail subjects but not yet disable.
- Trial name
- PRAISE (NCT06377436)
- Testing
- Experimental training
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Milan
Frailty, Retrospective Study
Post-acute Care for Patients With Frailty
Acute illness could be enormous stress for frail people. Combining comprehensive geriatric assessment and multifactorial intervention has positive effects on frail community older adults.
- Trial name
- NCT05452395
- Testing
- Post-acute care
- Where
- Taiwan
- Volunteers
- 254 people
- Sponsor
- Taipei City Hospital
Obesity
MOWI Home-Based Pilot
The goal of this study is to conduct a program of pilot research aimed at developing and evaluating a technology-assisted wellness intervention for older adults with obesity.
- Trial name
- NCT03104205
- Testing
- Evaluate home-based MOWI
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pre-Frailty, Aging
Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults
Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life.
- Trial name
- RtM (NCT07454616)
- Testing
- Supervised exercise program, a balanced micronutrient blend
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National University of Singapore
Physical Inactivity Frailty
A Digitally Supported Outdoor Physical Activity Intervention for Mildly Frail Older Adults in Hong Kong
The aging population in Hong Kong is projected to reach 36.6% by 2046, with roughly 16.6% of older adults estimated to be mildly frail-a condition linked to higher risks of falls, hospitalization, and mortality.
- Trial name
- NCT07752615
- Testing
- OUTDOOR-FIT, Active Control
- Where
- Hong Kong
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Frail Elderly
Comparison of the Effects of Different Exercise Protocols in Frail Elderly Individuals
The aim of this research is to investigate and compare the effects of two different exercise programs developed for frail geriatric individuals on fall risk, fear of falling, and physical performance.
- Trial name
- NCT07564076
- Testing
- Vivifrail Exercise Program, Otago Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Chronic Disease, Frail Elderly Syndrome
Evaluation of Community-based Care for the Frail Elderly
The term frail chronic complex patient (CCP) is generally applied to subjects with heterogeneous conditions that may represent at least one of the following three traits: (i) the need for management by a number of specialists…
- Trial name
- NCT03768050
- Testing
- Advanced care for frail elderly
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Clinic of Barcelona
Risk of Frailty in Elderly
Determinant of the Risk of the Becoming Frail in the Non-dependent Elederly
As an active and healthy ageing, "Successful Ageing" is a societal challenge for all countries members according to the European Commission.
- Trial name
- DEPART (NCT04012840)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Gérond'if
Fall, Fall Prevention
Study on the Steps to Avoid Falls in the Elderly
This study focuses on administering home-based exercises which include balance, strength, endurance, and mobility training to pre-frail subjects via one of the 3 intervention arms.
- Conditions
- Fall, Fall Prevention, Pre- Frail
- Trial name
- SAFETRIP (NCT05207215)
- Testing
- Home Base Exercises
- Where
- Singapore
- Volunteers
- 104 people
- Sponsor
- Singapore General Hospital
Frail Elderly
Long-term Effects of Interventional Strategies to Prevent Cognitive Decline in Elderly.
The MAPT PLUS study is a two-year extension of follow-up of the patients included in the MAPT preventive study, after completion of the interventions. Subjects in the four groups of the MAPT study will be prospectively followed.
- Trial name
- MAPT-PLUS (NCT01513252)
- Testing
- Gröber and Buschke test
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,028 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Glioblastoma Multiforme
Chemoradiotherapy Versus Chemotherapy for Elderly and Frail GBM Patients
Currently, the optimal treatment regimen for elderly Glioblastoma (GBM) patients with poor performance status (PS) is unknown. Based on data for elderly GBM patients and the limited data for patients with poor PS…
- Trial name
- NCT04765514
- Testing
- Temozolomide monotherapy, Chemo-Radiotherapy with concurrent temozolomide.
- Where
- 2 sites in Canada
- Volunteers
- 107 people
- Sponsor
- AHS Cancer Control Alberta
Multiple Myeloma, Relapse
Isa-Pom-Dex in Elderly/Frail Subjects With RRMM
This research study aims to evaluate the safety and effectiveness of the combination of isatuximab, pomalidomide, and dexamethasone (Isa-Pd) for the treatment of relapsed or refractory multiple myeloma (RRMM), which refers to…
- Conditions
- Multiple Myeloma, Relapse, Refractory, Aging
- Trial name
- NCT05911321
- Testing
- Isatuximab, Pomalidomide, Dexamethasone
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center