Clinical trials: Frail Older Adults
Frail Older Adutls
Systems Addressing Frail Elders (SAFE) Care Implementation
Systems Addressing Frail Elders (SAFE) Care is a nurse-led interprofessional team model to rapidly identify and provide safe and effective inpatient care to high risk older adults and help support their successful transition back…
- Trial name
- SAFE (NCT02854826)
- Testing
- SAFE Care model of care
- Volunteers
- 330 people
- Sponsor
- Cedars-Sinai Medical Center
Primary Central Nervous System Lymphoma (PCNSL), Zanubrutinib
Zanubrutinib Plus Lenalidomide for Frail Elderly Patients With Newly Diagnosed PCNSL
This is a prospective, single-arm, phase II clinical study evaluating the efficacy and safety of Zanubrutinib (a BTK inhibitor) plus Lenalidomide (an immunomodulatory drug) in frail elderly patients with newly diagnosed primary…
- Conditions
- Primary Central Nervous System Lymphoma (PCNSL), Zanubrutinib, Lenalidomide, Frail Elderly
- Trial name
- NCT07839247
- Testing
- Zanubrutinib, Lenalidomide
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Xiaohui Ren
Frailty, Esmolol
Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients
This topic will focus on the following questions: 1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the…
- Conditions
- Frailty, Esmolol, Myocardial Injury
- Trial name
- NCT05635877
- Testing
- Esmolol
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Yongtao Sun
Frail Elderly
Multicomponent Exercise and Comprehensive Geriatric Assessment Program (FRAIL+AP) for Frail Older Adults in Primary Care
Frailty is a multidimensional clinical syndrome associated with increased vulnerability to adverse health outcomes in older adults.
- Trial name
- FRAIL+AP (NCT07643064)
- Testing
- FRAIL+AP Program, Usual Care
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Alberto Bermejo Franco
Chronic Disease, Frail
Functional Exercise and Nutrition Education Program for Older Adults
There is strong evidence that specific types of exercise can improve health and physical function in older adults. While community exercise classes exist, many older adults with chronic conditions may need guidance from…
- Conditions
- Chronic Disease, Frail, Diabetes Mellitus, Cancer
- Trial name
- MoveStrong (NCT04037436)
- Testing
- Strength and Balance Training & Nutrition Education, Usual Care
- Where
- 5 sites in Canada
- Volunteers
- 44 people
- Sponsor
- University of Waterloo
Frail Elderly
Nordic Walking as Gait Training for Frail Elderly
The elderly are the fastest growing proportion of the population. Ageism implies a decline of physical functions affecting functional and safe ambulation.
- Trial name
- NCT00805220
- Testing
- Nordic Walking
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- McGill University
Leukemia
Azacitidine in Treating Patients With Newly Diagnosed Previously Untreated or Secondary Acute Myeloid Leukemia Who Are Unsuitable For Intensive Chemotherapy
RATIONALE: Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00739388
- Testing
- azacytidine
- Where
- 11 sites in Switzerland
- Volunteers
- 47 people
- Sponsor
- Swiss Cancer Institute
Colon Cancer, Colon Neoplasm
Geriatric Assessment and Intervention in Older Patients Undergoing Surgery for Colorectal Cancer
The GEPOC study investigates the effect of comprehensive geriatric assessment and intervention for frail older patients (65 years or older) undergoing elective surgery for colorectal cancer.
- Conditions
- Colon Cancer, Colon Neoplasm, Frail Elderly Syndrome, Colorectal Cancer
- Trial name
- GEPOC (NCT03719573)
- Testing
- Geriatric intervention
- Where
- Denmark
- Volunteers
- 67 people
- Sponsor
- Herlev and Gentofte Hospital
Frailty Syndrome, Older Adults
Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults
This randomized controlled trial study aims to evaluate the feasibility and preliminary efficacy of a combined inspiratory muscle training (IMT) and blood flow restriction (BFR) intervention in frail older adults.
- Conditions
- Frailty Syndrome, Older Adults, Blood Flow Restriction (BFR) Training Effects, Inspiratory Muscle Training
- Trial name
- NCT07573995
- Testing
- Exercise
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University
Aging, Sarcopenia
Effects of Resistance Training With High vs. Light-moderate Loads on Muscle-tendon Function in the Elderly
There are no unbiased studies that have analyzed the effects of resistance training with traditional, heavy versus light-moderate loads on muscle, tendon and bone in elderly people.
- Conditions
- Aging, Sarcopenia, Frail Elderly Syndrome
- Trial name
- NCT03724461
- Testing
- High Intensity resistance training (12 weeks), Light-moderate intensity resistance training (12 weeks), Control (12 weeks)
- Where
- Spain
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Frail Older Adults
CogXergaming to Promote Physical Activity and Cognitive Function in Frail Older Adults
Due to the age associated sarcopenia and reduced cardiovascular fitness, frail older adults experience significant decrease in physical function which comprises of mobility, endurance, muscle strength and balance control.
- Trial name
- NCT04534686
- Testing
- CogXergaming, Matter of Balance Training
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Illinois Chicago
Frail Elders
Evaluation of the Singapura Program of All Inclusive Care for the Elderly (SingaPACE) Demonstration Project
This is a RCT studying the effectiveness of the Singapore Program for All Inclusive Care for the Elderly (SingaPACE) demonstration project over a 36 month period.
- Trial name
- SingaPACE (NCT01568801)
- Testing
- SingaPACE
- Where
- 2 sites in Singapore
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Muscle Weakness, Postural Balance
Effects of a Multidisciplinary Intervention on Muscle Strength, Posture, and Balance in Older Adults After an Earthquake
This randomized controlled trial evaluated the effects of a 12-week multidisciplinary intervention on muscle strength, postural alignment, and balance in older adults living in temporary container settlements following the…
- Conditions
- Muscle Weakness, Postural Balance, Physical Functional Performance, Frail Elderly
- Trial name
- NCT07910981
- Testing
- Multimodal Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Frail Elderly Syndrome, Chronic Disease
Implementing Advance Care Planning Conversation Tools in Family Practice
This study evaluates the use of advance care planning conversation tools with patients attending their family doctor's office. Patients complete tools about their values and wishes, and a health care provider uses a structured…
- Trial name
- NCT03508557
- Testing
- Advance care planning tools
- Where
- 4 sites in Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Congestive Heart Failure, Cancer
Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP.
- Conditions
- Congestive Heart Failure, Cancer, Chronic Obstructive Pulmonary Disease, Cerebrovascular Accident
- Trial name
- NCT03577002
- Testing
- Serious Illness Care Program (SICP)
- Where
- 7 sites in United States, Canada
- Volunteers
- 1,120 people
- Sponsor
- Oregon Health and Science University
Frailty Syndrome, Respiratory Muscle Weakness
Longitudinal Ultrasound Assessment of Diaphragmatic and Respiratory Muscle Function Following Respiratory Muscle Training in Frail Older Adults
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on diaphragmatic and respiratory muscle function in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Respiratory Muscle Weakness, Age-Related Frailty, Geriatric Health
- Trial name
- IMT-1 (NCT07258615)
- Testing
- Inspiratory Muscle Training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Francisco de Vitoria
Frail Elderly, Coronary Artery Disease
Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients
Frailty is defined as a geriatric syndrome of impaired resiliency to stressors (such as cardiac surgery) that has been delineated recently in the cardiovascular literature.
- Trial name
- FRAGILE (NCT02338947)
- Testing
- Off-pump coronary-artery bypass grafting, On-pump coronary-artery bypass grafting
- Where
- 7 sites in United States, Brazil
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Atrial Fibrillation
Reaching the Frail Elderly for the Management of Atrial Fibrillation
The overall objective of the project is to develop a collaboration model between the patient, the patient's General Practitioner (GP) and the cardiologist at the hospital in a seamless collaborative model dubbed the "Cardio-relay…
- Trial name
- REAFEL (NCT04162548)
- Where
- Denmark
- Volunteers
- 344 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Hip Fracture
Back to the Future: Bridging the Hospital to Home Continuum After Hip Fracture
The purpose of this study is to determine whether is is feasible and acceptable to deliver a telephone based coaching intervention compared with education alone in community dwelling older adults (age 60 and older) after a fall…
- Trial name
- B2F (NCT01930409)
- Testing
- Telephone Support and Coaching, Education Only
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia