Clinical trials: Frail Older Adults
Solid Tumor
Screening for Vulnerability in the Elderly Supported at the Oscar Lambret Centre
The objective of this study is to uncover the prevalence of vulnerability among patients aged ≥ 70 coming to the medical oncology division of the Oscar Lambret Centre, according to the short screening test Vulnerable Elders…
- Trial name
- VULNERABILITE (NCT01415258)
- Where
- France
- Volunteers
- 209 people
- Sponsor
- Centre Oscar Lambret
Frail Elderly
Enhancing Physical Activity Levels of Frail Older People With a Wearable Activity Tracker-based Exercise Intervention
This study aims to investigate the feasibility, acceptability, and preliminary effects of a Wearable Activity Tracker (WAT)-based exercise intervention to increase physical activity levels in frail or pre-frail older people.
- Trial name
- NCT03538418
- Testing
- WAT
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Frail Elderly Syndrome
Frailty and Surgery
Frailty has been recently re-defined as a condition that is evident over time through an excess of vulnerability to stressors, with reduced ability to maintain or regain homeostasis after a destabilizing event, and occurrence of…
- Trial name
- NCT05594277
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Colorectal Cancer, Oncologic Complications
The SaVe Project-Sarcopenia and Vertigo in Aging Patients With Colorectal Cancer
The goal of this clinical trial is to learn about the cause of dizziness and decline in walking ability in in older adults ≥65 years during chemotherapy treatment for colorectal cancer.
- Conditions
- Colorectal Cancer, Oncologic Complications, Comprehensive Geriatric Assessment, Vestibular Rehabilitation
- Trial name
- SaVe (NCT05710809)
- Testing
- Targeted specialized physical group-based exercise and Comprehensive Geriatric Assessement
- Where
- 2 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Aging, Frail Elderly
Rehabilitation for Older Adults From Acute Medical Conditions
Hospitalization for an acute medical condition often results in functional decline in older adults. This loss of function often is not reversed after hospital discharge.
- Trial name
- STAGE (NCT00038155)
- Testing
- Ambulation training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- US Department of Veterans Affairs
Frail Elderly Syndrome
The Dynamics of Frailty in Older People
In the context of reduced resources and rising demand for unplanned care, the delivery of appropriate services to support people with frailty will be key to providing cost-effective, quality care for older people.
- Trial name
- NCT04139278
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 300,000 people
- Sponsor
- University of Southampton
Food Safety, Nutritive Value
Improving The Safety And Nutritional Adequacy Of The Home Food Supply Of Elderly Recipients Of Home Delivered Meals
Rutgers University will partner with the Meals on Wheels America (MOWA) and affiliated agencies in five states to conduct a study designed to improve food safety nutrition and emergency preparedness among homebound elderly…
- Conditions
- Food Safety, Nutritive Value, Homebound Persons, Frail Elderly
- Trial name
- NCT02719626
- Where
- 7 sites in United States
- Volunteers
- 740 people
- Sponsor
- Rutgers, The State University of New Jersey
Frailty, Pre-Frailty
In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults
The goal of this clinical trial is to determine whether a 6-month healthy-aging education program delivered in person, online, or in a hybrid format reduces frailty and is cost-effective compared with usual care in…
- Trial name
- FRAGSALUD-ON (NCT07738393)
- Testing
- In-person healthy aging education program, Hybrid healthy aging education program, Online healthy aging education program
- Where
- Spain
- Volunteers
- 276 people
- Sponsor
- University of Cadiz
Frail Elderly
Effectiveness of a Program Using Video Games Associated With Conventional Physiotherapy in Physical Functioning in Frail Elderly Compared to Conventional Physiotherapy
Frailty is a highly prevalent condition, reaching approximately 7% to 30% of older adults aged from 65 up to 80 years [2]. Although exercises seemed to be beneficial for the frail elders, there is still insufficient evidence to…
- Trial name
- NCT02333214
- Testing
- Exergames and conventional physiotherapy, Conventional physiotherapy
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Universidade Cidade de Sao Paulo
Frailty, Muscle Weakness
The Effects of Functional Power Training on Frail and Pre-frail Community - Dwelling Older Adults in Singapore
To investigate the efficacy of a 12-week Functional Power Training (FPT) program in pre-frail and frail community-dwelling older adults in Singapore for the management of physical frailty.
- Trial name
- NCT04438876
- Testing
- Functional Power Training, Usual care
- Where
- Singapore
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Geriatric Education and Research Institute
Alzheimer Disease, Frail Elderly Syndrome
Comparison of Kinesiophobia, Balance, Falling and Walking Speeds of Elderly's With Physical Frailty With Alzheimer's
In this study, Kinesiophobia, Balance, Falling, Walking Speeds of Elderly People with Cognitive Frailty with Alzheimer's Dementia, Elderly with Physical Frailty and Healthy Elderly Individuals will be compared.
- Trial name
- NCT05761665
- Testing
- Evaluation
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Mobility Limitation
Effects of Game-based Balance Exercise for Older Adults With Fall History
Due to the many problems associated with reduced balance and mobility, providing an effective and engaging rehabilitation regimen is essential to progress recovery from impairments and to help prevent further degradation of motor…
- Trial name
- NCT01381237
- Testing
- game-based balance exercises
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Perioperative Neurocognitive Disorders, Frail Elderly
A Predictive Study of Peripheral Blood Biomarkers on Postoperative Neurocognitive Dysfunction in Elderly Frail and Non-frail Patients Undergoing Gastrointestinal Surgery
Perioperative neurocognitive impairment (PND) mainly includes acute postoperative delirium (POD) and persistent postoperative cognitive impairment (POCD), which are common postoperative complications in elderly patients.
- Trial name
- NCT06334289
- Volunteers
- 338 people
- Sponsor
- Qianfoshan Hospital
Frail Elderly Persons, Cardiac Surgery
A Study Protocol for Research Investigating How Geriatric Risk Assessment and Shared Decision-making Conversations Affect Treatment Decisions and Quality of Life in Patients Eligible for Open-heart Surgery.
The goal of this study is to determine whether intervention by the PRIME clinic influences cardiac treatment decisions, as well as patients quality of life and healthcare utilization.
- Trial name
- PRIME (NCT06616129)
- Testing
- Geriatric assessment, Shared decision-making conversation
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- University Medical Center Groningen
Diffuse Large B-cells Non-Hodgkin Lymphoma
A Phase II Study of the FIL on Elderly Frail Patients With DLBCL
A phase II study to evaluate the combination of Lenalidomide and Rituximab as front line therapy for the treatment of elderly frail patients evaluated in CGA with Diffuse Large B-cells non-Hodgkin Lymphoma.
- Trial name
- NCT02955823
- Testing
- Rituximab-Dexamethasone-Lenalidomide
- Where
- 18 sites in Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Multimorbidity, Polypharmacy
OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients
This study is being done to find out if a multi-faceted intervention designed to optimize medication in hospitalized older people with multiple chronic medical conditions exposed to multiple medications can reduce unplanned…
- Trial name
- OPTIMATE (NCT05387096)
- Testing
- Definitive multi-faceted intervention consisting of several components
- Where
- 3 sites in Belgium, Ireland
- Volunteers
- 642 people
- Sponsor
- University College Cork
Older Adults, Gastro-Intestinal Cancer
PeRsonalizing the Approach to the Oncologic Frail Individual Through Tailored Assessment and Intervention (PROFIT Study)
The PROFIT study has two complementary aims. The first aim is to compare, in a cohort study enrolling N=257 older adults (>65 years) with lung, gastrointestinal and prostate cancer, different easy measures of frailty (Geriatric 8…
- Conditions
- Older Adults, Gastro-Intestinal Cancer, Prostate Cancer, Lung Cancer
- Trial name
- PROFIT (NCT05319145)
- Testing
- Intervention group, Control group
- Where
- 3 sites in Andorra, Spain
- Volunteers
- 268 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Influenza
High-Dose Influenza Vaccine in Nursing Homes
The purpose of this study is to prospectively evaluate relative effectiveness of high dose influenza vaccine in preventing influenza mortality, hospitalization, and functional decline in a nursing home population in the U.S.…
- Trial name
- NCT01815268
- Testing
- HD Vaccine, SD Vaccine, Free Vaccine
- Where
- 3 sites in United States
- Volunteers
- 823 people, healthy volunteers welcome
- Sponsor
- Insight Therapeutics, LLC
Frail Elderly Syndrome, Surgery
Development and Validation of a Preoperative Frailty Index Using Health Administrative Data
The investigators will create a frailty index using health administrative data available for older people having surgery. The index will be based on the Canadian Study of Health and Aging Frailty Index and standard…
- Conditions
- Frail Elderly Syndrome, Surgery, Outcomes, Predictive Value of Tests
- Trial name
- NCT03354546
- Testing
- Frailty index
- Volunteers
- 511,285 people
- Sponsor
- Ottawa Hospital Research Institute
Frailty
Observatory of the Older Person: A Cohort of Older Adults Living in Nursing Homes
This cohort of older adults residing in nursing homes in Porto Metropolitan Area aims to monitor the health, intrinsic capacity and functional capacity over time.
- Trial name
- NCT06825026
- Testing
- Pragmatic exercise trial
- Where
- Portugal
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto