Clinical trials: Frail Older Adults
Postoperative Delirium
Factors Affecting the Incidence of Postoperative Delirium in Frail Elderly
Postoperative delirium has been found to be associated with increased risk of future neurocognitive decline and mortality especially in elderly patients.
- Trial name
- NCT02227225
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Chronic Disease, Frail Elderly Syndrome
Evaluation of Community-based Care for the Frail Elderly
The term frail chronic complex patient (CCP) is generally applied to subjects with heterogeneous conditions that may represent at least one of the following three traits: (i) the need for management by a number of specialists…
- Trial name
- NCT03768050
- Testing
- Advanced care for frail elderly
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Clinic of Barcelona
Hypertension
Impact of Reducing Antihypertensive Treatment on Mortality in Frail Subjects With Low Systolic Blood Pressure (SBP).
The investigators hypothesize that a gradual reduction in antihypertensive treatment in medical-social institutions patients with low systolic blood pressure (SBP) can improve survival through a controlled increase in SBP and a…
- Trial name
- RETREAT-FRAIL (NCT03453268)
- Testing
- STEP DOWN strategy, Control
- Where
- 124 sites in France
- Volunteers
- 1,048 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Myeloma, Myeloma
Multicenter Open Label Phase 3 Study of Isatuximab Plus Lenalidomide and Dexamethasone With/Without Bortezomib in the Treatment of Newly Diagnosed Non Frail Transplant Ineligible Multiple Myeloma Elderly Patients (≥ 65; < 80 Years).
Overall the issue of patients above 65-70 years of age being that it is impossible for most of them to undergo an intensive treatment like autologous stem cell transplant with little prospect of debulking effectively the bone…
- Trial name
- NCT04751877
- Testing
- Isatuximab, Lenalidomide, Bortezomib
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Poitiers University Hospital
Frail Elderly Syndrome
Mobile Geriatric Teams: Patient Safety and Healthcare Utilization
Objective To perform a prospective, controlled and randomized evaluation of the effectiveness of Mobile Geriatric Teams (MGT). Method Community-dwelling, frail elderly people were randomized to intervention group (n=31, mean age…
- Trial name
- MGT (NCT03662945)
- Testing
- Mobile Geriatric Team intervention
- Volunteers
- 62 people
- Sponsor
- Jonkoping University
Rehabilitation
Blood Flow Restriction With Aerobic Exercise in Frail Older Adults
Background:Frailty is most often defined as a syndrome of physiological decline in late life, characterized by marked vulnerability to adverse health outcomes.
- Trial name
- NCT06155227
- Testing
- aerobic exercise combined with blood flow restriction, aerobic exercise
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng Kung University
Hip Osteoarthritis, Knee Osteoarthritis
FitJoints: Getting Fit for Hip and Knee Replacement
Total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis.
- Trial name
- NCT05100966
- Testing
- FitJoints Multi-modal Intervention
- Where
- 4 sites in Canada
- Volunteers
- 192 people
- Sponsor
- McMaster University
Frail Elderly
Effects of Remote Exercise on Physical Function in Pre-Frail Older Adults
This study aims to compare the effects of remote versus in-person exercise interventions on physical function, balance, gait stability, and fall efficacy in pre-frail older adults aged 65 years and above.
- Trial name
- NCT06672640
- Testing
- Remote Exercise Program, In-Person Exercise Program, Physical Activity Education
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Kyungdong University
Frail Elderly Syndrome
Older Adult Safety in Surgery IV (OASIS)
Use of remote coaching and walking plan prior to surgery to improve stamina and mobility in frail older adult surgical patients after surgery.
- Trial name
- OASIS (NCT03892187)
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Massachusetts, Worcester
Heart Failure, Prefrail Elderly
High-technology TeleRehabilitation for the Treatment of the FRAgile Patient
The aim of this randomized controlled clinical trial is to evaluate the efficacy of an 8-week sensorimotor and cognitive telerehabilitation program in frail and pre-frail older adults with stable chronic heart failure.
- Conditions
- Heart Failure, Prefrail Elderly, Frail Elderly Syndrome
- Trial name
- TeleRiab4Fra (NCT07561021)
- Testing
- Telerehabilitation, Caregiver-Supervised Home Exercise Program
- Volunteers
- 70 people
- Sponsor
- University of Salerno
Fall, Fall Prevention
Study on the Steps to Avoid Falls in the Elderly
This study focuses on administering home-based exercises which include balance, strength, endurance, and mobility training to pre-frail subjects via one of the 3 intervention arms.
- Conditions
- Fall, Fall Prevention, Pre- Frail
- Trial name
- SAFETRIP (NCT05207215)
- Testing
- Home Base Exercises
- Where
- Singapore
- Volunteers
- 104 people
- Sponsor
- Singapore General Hospital
Frailty, Aging
AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program
Aim 1: To assess the feasibility and acceptability of delivering AGE SELF CARE through virtual medical group visits by measuring recruitment rate, adherence, and participant satisfaction.
- Conditions
- Frailty, Aging, Frailty Syndrome, Frail Elderly Syndrome
- Trial name
- NCT06079762
- Testing
- AGE SELF CARE group visit program
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Hypertension
Relationship Between 24-hour Blood Pressure Variability and FRagility in the Elderly Patient
In the 2016's Haute Autorité de Santé (HAS) recommendations (Haute Autorité de Santé. Management of arterial hypertension in adults.
- Trial name
- VAR-24hFR (NCT05818280)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Pr. Nicolas GIRERD
Frail Elderly Syndrome
Home-based Prehabilitation for Elderly Patients
As a consequence of the increasing life expectancy hospitals are seeing a growing number of elderly patients undergoing elective surgery.
- Trial name
- TRAilty (NCT03964363)
- Testing
- Unsupervised home-based physical prehabilitation
- Where
- 3 sites in Germany
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Frailty, Old Age; Debility
The Effects of a Tele-health Program
Frailty is a state of being vulnerable and functional disable due to age-related decline of multiple physiological systems, and is often associated with higher risk of falls, institutionalization, hospitalization, disability…
- Trial name
- NCT05267444
- Testing
- Individualized motion-based interactive game program
- Where
- Hong Kong
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Risk of Frailty in Elderly
Determinant of the Risk of the Becoming Frail in the Non-dependent Elederly
As an active and healthy ageing, "Successful Ageing" is a societal challenge for all countries members according to the European Commission.
- Trial name
- DEPART (NCT04012840)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Gérond'if
Frail Elderly, Exercise Therapy
A Multi-component Intervention in Frail Community-dwelling Older People
This study evaluates if a multi-component intervention, respecting the characteristics of frail older person and increasing intensity and challenge of exercises according to frail older person capacity/evolution will induce…
- Conditions
- Frail Elderly, Exercise Therapy, Physical Therapy Techniques
- Trial name
- MIF (NCT02918682)
- Testing
- Exercise - FIRST PHASE, Exercise - SECOND PHASE, Exercise - FOURTH PHASE
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Coronary Artery Disease, Valvular Heart Disease
PRehabilitiation in Elective Frail and Elderly Cardiac Surgery PaTients
Older and more frail adults are more often being referred for cardiac surgery. These patients are often in suboptimal health, and may be physically frail, malnourished, and have other conditions, such as diabetes, that complicate…
- Trial name
- PREFECT (NCT03399162)
- Testing
- PREHAB Workshop, PREHAB Exercise Program
- Where
- Canada
- Sponsor
- Ottawa Heart Institute Research Corporation
Hip Fracture
Postoperative Blood Transfusion for Frail Elderly With Hip Fracture
Elderly with hip fractures are often frail and discharged from hospital after few days of hospitalisation. Hip fracture surgery is often associated with blood loss, where the patient is at risk of developing anaemia.
- Trial name
- NCT01102010
- Testing
- Blood transfusion
- Where
- Denmark
- Volunteers
- 284 people
- Sponsor
- University of Aarhus
Elderly, Frail
Effects of Multimodal Prehabilitation on Frail Elderly Patients Undergoing Elective Gastric Cancer Surgery
Research indicates that prehabilitation is effective in optimizing physical status before surgery, although this method may be considered "aggressive" for frail elderly patients.
- Conditions
- Elderly, Frail, Gastric Cancer, Prehabilitation
- Trial name
- NCT06510088
- Testing
- 3-week multimodal prehabilitation program
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University