Clinical trials: Frailty/Sarcopenia
Parkinson Disease
The UPbeating GReek Application of DancE in Parkinson's Disease Clinical Trial
Dance for Parkinson's Disease® (DfPD®) is a specially designed dance program for individuals with PD. This study assesses the efficacy, safety and feasibility of a culturally adapted DfPD® program offered both live and online in…
- Trial name
- UPGRADE-PD (NCT06220084)
- Testing
- Dance for PD®
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of West Attica
End-Stage Liver Disease, Liver Transplantation
Multidimensional Frailty Assessment and Post-Transplant Outcomes in Liver Transplant Candidates
This study will evaluate frailty, nutrition, sarcopenia, and psychological health in people waiting for a liver transplant. The purpose is to understand how these factors affect outcomes before and after transplantation.
- Conditions
- End-Stage Liver Disease, Liver Transplantation, Cirrhosis
- Trial name
- NCT07414095
- Testing
- Comprehensive Observational Assessment in Liver Transplant Candidates
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir Bakircay University
Frailty, Sarcopenia
Promoting Autonomy Through ExerCisE (PACE) in Outpatient Geriatric Clinics
Physical inactivity is highly prevalent among older adults and is associated with declines in physical function, independence, quality of life, and social participation.
- Trial name
- PACE - OGC (NCT07787663)
- Testing
- PACE
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- Université du Québec a Montréal
Sarcopenia, Old Age; Debility
Study of the Validity and Reliability of Two Digital Dynamometers in Older People
It is a cross-sectional, randomized, and single-center study with a duration of 6 months. The study will follow the STROBE guidelines for cross-sectional studies and CONSORT 2024.
- Conditions
- Sarcopenia, Old Age; Debility, Frailty
- Trial name
- SOVARDDIOP (NCT06623019)
- Testing
- Validation and reliability
- Where
- Spain
- Volunteers
- 413 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Frailty/Sarcopenia, Frailty in Older Adults
Effects of a Community-based Multicomponent Physical Exercise Program on Physical Function, Frailty, and Sarcopenia in Older Adults From the Municipality of Santoña: a Quasi-experimental Study.
This study evaluates the effects of a community-based multicomponent exercise program on physical function, frailty, and sarcopenia in older adults living in the municipality of Santoña (Cantabria, Spain).
- Conditions
- Frailty/Sarcopenia, Frailty in Older Adults, Sarcopenia
- Trial name
- NCT07732478
- Testing
- Multicomponent Exercise Program (Vivifrail-based)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Universidad de Granada
PROSTATE CANCER, Metastatic Prostate Cancer
Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial
The purpose of this study is to determine whether a 16-week supervised, clinic-based circuit training intervention utilizing resistance and functional exercises and self-directed aerobic exercise will improve frailty and…
- Conditions
- PROSTATE CANCER, Metastatic Prostate Cancer, Metastatic Prostate Carcinoma
- Trial name
- NCT06040125
- Testing
- Supervised Circuit Training
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Dana-Farber Cancer Institute
Sarcopenia
Evaluation of Frailty in Patients With Fibrosing Interstitial Lung Diseases: Prognostic and Therapeutic Impact
Fibrosing interstitial lung diseases (ILDs), with idiopathic pulmonary fibrosis being the most common form, primarily affect older individuals and have a poor prognosis, with a median survival of 3 to 5 years.
- Trial name
- FRAPID (NCT07004595)
- Testing
- Evaluation of patient frailty
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Strength, Quality of Life
Update on the Detection of Frailty in Older Adults
The main objective is to update the diagnostic assessment of frailty by correlating several variables with the ultrasound image of the frail elderly patient.
- Conditions
- Strength, Quality of Life, Functional Independence, Functionality
- Trial name
- NCT06218121
- Testing
- Instrumental and Functional Tests that Assess Functional Capacity
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Universidad Europea de Madrid
Ambulatory Geriatric Outpatients at High Risk of Frailty
Impact of Chronic Disease Control and Aging Psychology on Outcomes of Frailty-Sarcopenia Syndrome in Ambulatory Geriatric Patients
Pursuant to our previous longitudinal study (ClinicalTrials.gov ID: NCT02073370) in geriatric outpatients cooperated with the Department of Family Medicine, Department of Geriatrics and Gerontology, National Taiwan University…
- Trial name
- NCT02160093
- Where
- Taiwan
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Frail Elderly Syndrome, Emergencies
Frailty and Sarcopenia Outcomes in Emergency General Surgery
1. A retrospective scoping cohort review of adult patients undergoing emergency laparotomy/laparoscopy for acute gastrointestinal (GI) pathology who have had a CT scan of the abdomen(+/- pelvis).
- Conditions
- Frail Elderly Syndrome, Emergencies, Surgery, Sarcopenia
- Trial name
- FrOGS (NCT03534765)
- Testing
- CT abdomen +/- pelvis, Edmunton Frailty Score, Emergency laparotomy for general surgical pathology
- Where
- 10 sites in United Kingdom
- Volunteers
- 294 people
- Sponsor
- Yeovil District Hospital NHS Foundation Trust
Sarcopenia, Frailty
Prevalence of Two Major Geriatric Syndromes: Sarcopenia and Frailty
Sarcopenia and frailty are two major syndromes in older adults. They are shown to be associated with low levels of functioning and higher rates of morbidity and mortality.
- Conditions
- Sarcopenia, Frailty, Frailty Syndrome
- Trial name
- NCT04146844
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Goztepe Training and Research Hospital
Sarcopenia
Exercise and Nutrition for Healthy AgeiNg
The aim of this randomized placebo-controlled 5-arm clinical trial is to evaluate the effect of combined anabolic interventions compared to single or placebo interventions on physical performance in community-dwelling…
- Trial name
- ENHANce (NCT03649698)
- Testing
- Home-based training program, High-quality protein supplement, Omega-3 fatty acid
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Frailty, Sarcopenia
Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty
Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern.
- Trial name
- IMPACT (NCT04717869)
- Testing
- Ultrasound, Biomarker Analysis, Frailty Index
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of California, Los Angeles
Sarcopenia, Frailty
Sarcopenia in Older Patients in the Acute Hospital Setting
This study will assess whether the use of technology using the Virtual Gate Device (VGD) will prevent or minimize the development of hospital acquired Sarcopenia resulting from Immobilization.
- Trial name
- NCT04092790
- Testing
- Virtual Gate Device (VGD)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rambam Health Care Campus
Sarcopenia
Multicomponent Intervention for Physical Frailty and Sarcopenia
The SPRINTT study will evaluate the efficacy of a multicomponent intervention programme (physical activity, nutritional counselling/dietary intervention, and information and communications technology intervention) compared with a…
- Trial name
- SPRINTT (NCT02582138)
- Testing
- Multicomponent intervention (MCI), Healthy Aging Lifestyle Education (HALE)
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Frailty, Sarcopenia
Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery
The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.
- Conditions
- Frailty, Sarcopenia, Sarcopenia in Elderly, Muscle Strength
- Trial name
- NCT06988176
- Testing
- Frailty assessment, nutrition assessment, cognition assessment, muscle strength testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Sarcopenia
A Study of Muscle Strength Maintenance in Older Adults
This research study is being done to see whether losartan can prevent the decrease in strength associated with aging. Muscle loss is associated with aging and has multiple symptoms such as weakness, slowness, and fatigue…
- Trial name
- NCT01989793
- Testing
- Losartan
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mobility
Best Function of Range of Motion (cRCT)
Mobility is a crucial factor for independence and quality of life in older people. However, the majority of those in retirement homes are not physically active to maintain mobility and independence.
- Trial name
- bestform (NCT04207307)
- Testing
- Multimodal exercise program, Usual Care
- Where
- Germany
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Frailty, Sarcopenia
The Effect of the COVID-19 Pandemic on Frailty in Liver Transplant Candidates
Frailty is associated with higher rates of morbidity, mortality, and failure to rescue after major surgical procedures. Sarcopenia is degenerative loss of skeletal muscle mass and strength.
- Conditions
- Frailty, Sarcopenia, COVID-19
- Trial name
- NCT05935800
- Testing
- COVID Patients who Underwent pre-transplant frailty assessment (PFA) at MDMC
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Methodist Health System
Fragility, Sarcopenia
Efficacy of an Intervention to Prevent Frailty in Obese Elderly People (PRE-FROB)
Rationale: There is increasing evidence that obesity may be a risk factor for frailty in the elderly. Obesity favors a state of chronic inflammation and insulin resistance, involves a fatty infiltration of the muscle and an…
- Conditions
- Fragility, Sarcopenia, Obese, Elderly
- Trial name
- PRE-FROB (NCT03000907)
- Testing
- Intervention
- Where
- Spain
- Volunteers
- 319 people
- Sponsor
- Consorci Sanitari del Maresme