Clinical trials: Frailty, completed
Frailty, Aging
Phase I: Safety and Efficacy of an Injectable Follistatin Plasmid Gene Therapy in Humans
This study examines the safety and effects of an injectable plasmid gene therapy. Plasmids are circular pieces of DNA which have been widely studied as a non-permanent \& non-heritable method for transferring genes and inducing…
- Trial name
- NCT06411366
- Testing
- Follistatin plasmid
- Where
- Honduras
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Minicircle
COVID-19
A Study to Understand How the Use of Paxlovid Affected Healthcare Use in People With Pre-existing Conditions.
This is a cohort study that will include Paxlovid (nirmatrelvir-ritonavir) treatment eligible for people with a positive SARS-CoV-2 diagnostic test and at least one COVID-19 symptom.
- Trial name
- NCT07090486
- Testing
- nirmatrelvir-ritonavir
- Where
- United States
- Volunteers
- 14,000 people
- Sponsor
- Pfizer
Aging Frailty
Phase IIb Trial to Evaluate Longeveron Mesenchymal Stem Cells to Treat Aging Frailty
This is a randomized, placebo-controlled, double-blind, parallel arm, multi-center Phase 2b study.
- Trial name
- NCT03169231
- Testing
- Longeveron Mesenchymal Stem Cells (LMSCs)
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- Longeveron Inc.
Frailty
AllogeneiC Human Mesenchymal Stem Cells (hMSC) in Patients With Aging FRAilTy Via IntravenoUS Delivery
The purpose of this study is to look at the safety of treatment with stem cells in patients with Frailty.
- Trial name
- CRATUS (NCT02065245)
- Testing
- Allogeneic Human Mesenchymal Stem Cells (allo-hMSCs), Penicillin/Streptomycin-Free Allogeneic Human Mesenchymal Stem Cells (allo-hMSCs)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Longeveron Inc.
Frailty, Sarcopenia
Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older Adults
The study is a single-center, randomized, placebo-control double-blind study in frail older adults over 65yrs. to investigate the impact of Mitopure (Urolithin A) supplementation on muscle mitochondrial quality in frail older…
- Conditions
- Frailty, Sarcopenia, Aging, Muscle Atrophy
- Trial name
- MitoEM (NCT06556706)
- Testing
- Mitopure (Urolithin A)
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Amazentis SA
Herpes Zoster
A Study to Assess Frailty of Subjects During ZOSTER-006 and ZOSTER-022
As part of the ZOSTER-006 and ZOSTER-022 pivotal trials of the HZ/su vaccine, all study participants completed quality of life (QoL) questionnaires.
- Trial name
- NCT03563183
- Testing
- Encoding of data collected in Zoster 006 and Zoster 022 studies
- Where
- 169 sites in United States, Australia and 16 more
- Volunteers
- 26,976 people
- Sponsor
- GlaxoSmithKline
Coronavirus Disease 2019 (COVID-19)
A Study to Learn About the Study Medicine Paxlovid (Nirmatrelvir + Ritonavir) in Adults Aged 60 and Older Living in Korean Long-term Care Hospitals Who Have COVID-19
The purpose of this study is to learn about the effects of the study medicine (called Paxlovid) for the possible treatment of COVID-19 in older adults who live in long-term care hospitals (LTCHs) in Korea.
- Trial name
- NCT07089680
- Testing
- Nirmatrelvir/Ritonavir
- Where
- 7 sites in South Korea
- Volunteers
- 937 people
- Sponsor
- Pfizer
Frailty in Older Adults
Allogeneic Human Mesenchymal Stem Cell Infusion for Frailty Patient
Subjects will be provided a written informed consent to participate in the study and then undergo any screening. Subjects who meet all the inclusion criteria and none of the exclusion criteria based on the screening test results…
- Trial name
- NCT07449364
- Testing
- Daewoong Biologics Indonesia Umbilical Cord-derived Mesenchymal Stem Cell (DBI UC-MSC)
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Daewoong Group Indonesia
Sarcopenia, Frailty
Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty
The study will be conducted to investigate the efficacy, tolerability and pharmacokinetics of MYMD1 in participants with chronic inflammation associated with sarcopenia/frailty, a condition linked to elevated levels of…
- Conditions
- Sarcopenia, Frailty, Aging
- Trial name
- NCT05283486
- Testing
- MYMD-1 600MG, MYMD-1 750mg, MYMD-1 900mg
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- TNF Pharmaceuticals, Inc.
Aging, Frailty
Mitophagy and Autophagy in Elderly Subjects
In recent years, evidence has shown that mitochondrial dysfunction plays an important role in the development of age-related muscle decline that may lead to frailty.
- Conditions
- Aging, Frailty, Mitophagy
- Trial name
- NCT02472340
- Testing
- Muscle Biopsy
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Frailty, Muscle Loss
A Randomized-Control Study of Gym Tonic's Community Based Strength Training Intervention.
Launched in April 2015 , Gym Tonic is the first of its kind cross-border exercise-as-medicine partnership between research institutions, business enterprises and service providers from Singapore and Finland.
- Conditions
- Frailty, Muscle Loss, Sarcopenia
- Trial name
- NCT04661618
- Testing
- Gym Tonic programme and Gym equipment
- Where
- Singapore
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- PulseSync Pte Ltd
Aging Frailty
Lomecel-B on Vaccine-Specific Antibody- Response in Subjects With Aging Frailty
This is a phase I/II, randomized, blinded and placebo-controlled study to test the safety and efficacy of Lomecel-B for improving vaccine immune response.
- Trial name
- HERA (NCT02982915)
- Testing
- Longeveron Mesenchymal Stem Cells (LMSCs), Fluzone High Dose Vaccine
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- Longeveron Inc.
Aging Frailty
A Study to Evaluate Allogenic Bone-Marrow Mesenchymal Stromal Cell Product StromaForte in Aging Frailty Patients
This phase I/IIa study in frail patients is designed to assess the safety of intravenous human allogenic bone marrow-derived mesenchymal stromal cell product StromaForte by reporting the number of adverse events assessed by…
- Trial name
- NCT06063590
- Testing
- StromaForte
- Where
- United Arab Emirates
- Volunteers
- 12 people
- Sponsor
- Cellcolabs Clinical SPV Limited
Frail Elderly Syndrome
A Machine Learning Algorithm to Predict Health Clinical Situations in Primary Healthcare for Frail Older Adults.
Introduction: We developed a machine learning algorithm to predict the risk of emergency hospitalization within the new 7 to 14 days with a good predictive performance (AUC=0.85).
- Trial name
- NCT06013709
- Testing
- PRESAE CARE
- Volunteers
- 1,478 people
- Sponsor
- Presage
Multiple Myeloma
Integrating Touchscreen-based Geriatric Assessment and Frailty Screening for Adults With Multiple Myeloma
The overarching objective of this study is to evaluate the feasibility, usability, and acceptability of an abbreviated, tablet-based geriatric assessment in a population of older adults with multiple myeloma.
- Trial name
- NCT03068637
- Testing
- Carevive CPS
- Where
- 2 sites in United States
- Volunteers
- 165 people
- Sponsor
- Carevive Systems, Inc.
Heart Failure
FRailty WAlking Patterns (FRAP) Study
The aim of this study is to evaluate sit-stand phases and gait speed detection using an externally worn Reveal LINQ (TM) compared to an external reference (3D accelerometer, and/or the Computer Assisted Rehabilitation Environment…
- Trial name
- FRAP (NCT02755129)
- Testing
- Walking Exercises-Six Minute Walk (6MW) Test, Walking Exercises-4 Meter Gait Speed (4MGS) Test, Walking Exercises-Five Times Sit to Stand (FTSTS) Test
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Medtronic BRC
Fraility, Risk of Falling
Physical Activity Monitoring in Frailty and Falling
BioSensics has developed a Physical Activity Monitoring System (PAMSys) that consists of a single wearable motion sensor that is worn on the torso.
- Trial name
- NCT01880229
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- BioSensics