Clinical trials: Frailty in Older Adults
Frailty, Anesthesia Induction
ED50 of Remimazolam for Anesthesia Induction in Frail Elderly Patients
This study aimed to determine the median effective dose (ED50) of remimazolam for loss of consciousness (LOC) in elderly and frail elderly patients using the Dixon up-and-down method, while utilizing a novel Respiratory Volume…
- Trial name
- NCT07467603
- Testing
- Remimazolam Tosilate
- Where
- China
- Volunteers
- 58 people
- Sponsor
- The First Hospital of Hebei Medical University
Elderly Infection, Frailty
Antibiotic Dosing in Geriatric Patients At the Emergency Department
In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate…
- Conditions
- Elderly Infection, Frailty, Frail Elderly Syndrome, Infection, Bacterial
- Trial name
- AGED (NCT04436991)
- Testing
- Blood sampling, Sputum sample, Hemoculture
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- University Hospital, Ghent
Postoperative Cognitive Dysfunction, Postoperative Delirium
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Frailty
- Trial name
- POCD (NCT04837391)
- Testing
- Near Infrared Spectroscopy (NIRS), Blood sample, Addenbrooke Cognitive Examination III (ACE-III)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul University
Frailty
Metformin for Preventing Frailty in High-risk Older Adults
Frailty is a geriatric syndrome which leads to poor health outcomes in older adults, such as falls, disability, hospitalization, institutionalization, and death. Due to the dramatic growth in the U.S.
- Trial name
- NCT02570672
- Testing
- Metformin
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Frail Elderly Syndrome, Acute Coronary Syndrome
Frailty Assessment in Elderly Patients With Acute Coronary Syndrome
Frailty is known as an independent risk factor for morbidity and mortality in older cardiac patients . It is an important factor on the cardiologist decision between conservative and invasive treatment in older patient with acute…
- Trial name
- NCT03365505
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Elderly Inpatients, Frail
Prevalence and Influencing Factors of Frailty in Elderly Patients With Heart Failure
The goal of this observational study is to investigate the prevalence and associated factors of frailty in hospitalized elderly patients with heart failure.
- Conditions
- Elderly Inpatients, Frail, Heart Failure Hospitalization, CGA
- Trial name
- NCT07510035
- Where
- China
- Volunteers
- 298 people
- Sponsor
- Zhejiang Hospital
Frailty
Blood Flow Restriction on Functional Mobility in Pre-frail Older Adults
This study investigates the effect of blood flow restriction with resistance exercise on functional mobility in pre-frail older adults.
- Trial name
- NCT05209685
- Testing
- Resistance exercise on the lower extremities, Resistance exercise on the lower extremities with blood flow restriction
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- National Cheng Kung University
Frailty, Sarcopenia
Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery
The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.
- Conditions
- Frailty, Sarcopenia, Sarcopenia in Elderly, Muscle Strength
- Trial name
- NCT06988176
- Testing
- Frailty assessment, nutrition assessment, cognition assessment, muscle strength testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Cognitive Impairment, Frail Older Adults
Cognitive Fraility and Biomarkers in Older Patients
this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective…
- Conditions
- Cognitive Impairment, Frail Older Adults, Orthopaedic Surgery
- Trial name
- NCT07184073
- Testing
- assessment Mini mental state examination, assessment FRAIL scale, collecting cerebrospinal fluid during regional anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Baskent University
Geriatrics, Fragility
Evaluation of Metabolic Syndrome, Frailty, Locomotive Syndrome, Balance and Physical Fitness in Elderly Individuals
Metabolic syndrome (MetS) or syndrome X, which is increasingly prevalent in the world and in our country, is a disease that includes abdominal obesity, dyslipidemia, impaired glycemic control and hypertension components.
- Conditions
- Geriatrics, Fragility, Locomotor, Physical Fitness
- Trial name
- NCT05938153
- Testing
- observational physical tests
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Kırıkkale University
Frail Elderly Patients
A Multicenter Observational Study of an Integrated Traditional Chinese and Western Medicine Care Model in Post-Acute Treatment of Frail Elderly Patients
Exploring the Impact and Effectiveness of an Integrated Traditional Chinese and Western Medicine Treatment Model in Post-Acute Care for Frail Older Patients.
- Trial name
- NCT07136935
- Testing
- Traditional Chinese Medicine treatment
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- China Medical University Hospital
Impaired Cognition, Quality of Life
The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery
The primary aim of this study is to establish if it is possible for patients who have undergone major body surgery to complete a home based exercise training program and complete the assessments required to measure physical and…
- Conditions
- Impaired Cognition, Quality of Life, Surgery, Delirium
- Trial name
- POETold (NCT03064308)
- Testing
- Exercise Programme
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Nottingham
Healthy, Frailty
Geriatric Anorexia Study 2.0
Reduction in appetite and/or food intake among older individuals is referred to as anorexia of aging (AOA, also known as Geriatric Anorexia).
- Trial name
- GAS2 (NCT05211973)
- Testing
- Wrist Actigraphy Device, Smart Body Weight Scale, Chair Scale
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Boston University
Frail Elderly Syndrome
Assessing a New Tool to Assess Frailty in Frail Hospitalized Elderly
The major purpose of this study is to establish the use of daily step counts as inexpensive, easy to measure marker for frailty and sarcopenia in an inpatient population of older adults.
- Trial name
- NCT04366388
- Testing
- ActivPAL3 VT (PAL Technologies Ltd).
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Frailty
Nutraceuticals and Drug Treatment in Frail Older Adults
Frailty is a multidimensional condition due to reserve loss leading to physical and cognitive impairment that is very common in older adults; in fact, its incidence increases with age.
- Trial name
- NCT04962841
- Testing
- Nutraceuticals
- Where
- Italy
- Volunteers
- 485 people
- Sponsor
- University of Campania Luigi Vanvitelli
Old Age; Debility
Multicomponent Exercises in Functional Performance and Cognitive Ability of Hospitalized Elderly
Older patients spend most of their time in situations of muscle disuse during acute hospitalization. Physical inactivity is a key factor for the development of adverse events caused by hospitalization, known as iatrogenic…
- Trial name
- NCT05317338
- Testing
- Group-based exercise training during hospitalization
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Sedentary Behavior, Frailty
Effects of Intermittent Hypoxia-Hyperoxia in Older Adults
The supply of oxygen is essential for energy production, recovery from efforts, and human life. Intermittent Hypoxia-Hyperoxia Exposure (IHHE) is a novel technique in which the subject is exposed to a respiratory environment with…
- Conditions
- Sedentary Behavior, Frailty, Older Adults
- Trial name
- NCT06686316
- Testing
- Device: Hypoxic Gas Mixture
- Volunteers
- 16 people
- Sponsor
- Sierra Varona SL
Frail Elderly
Video Decision Support for Advance Care Planning in Geriatric Patients With Frailty
As the proportion of the aging population continues to rise, age-related frailty syndrome, characterized by a decline in the function of multiple physiological systems and accompanied by vulnerability to stress, has become a…
- Trial name
- NCT06671353
- Testing
- video decision aid
- Where
- Taiwan
- Volunteers
- 96 people
- Sponsor
- National Taiwan University Hospital
Fragility, Cancer
Frailty Evaluation in Elderly Population With Cancer
The Comprehensive Geriatric Assessment (CGA) is, still today, barely established in the standard practice. Although the different scientific societies recommend a CGA in elderly population affected with cancer at first visit, the…
- Trial name
- ELDERLY (NCT03101631)
- Testing
- Comprehensive Geriatric Assessment (CGA)
- Volunteers
- 62 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Frailty, Muscle Weakness
Effectiveness of Protein Supplementation on Frailty Improvement, Muscle Strength and Physical Performance Among Pre-Frail Elderly People
The goal of this randomized clinical trial is to study the effectiveness of protein supplements in frailty improvement, muscle strength, physical performance, energy intake and body composition of pre-frail elderly people.
- Conditions
- Frailty, Muscle Weakness, Physical Dependence, Weight Loss
- Trial name
- NCT05648617
- Testing
- SUSTINEX Hydrolyzed Whey Protein
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia