Clinical trials: Free Flap Reconstruction
Tongue Squamous Cell Carcinoma, Mixed Reality
Resection and Defect Repair of Oral Cancer Aided by Mixed Reality Technology
The objective of this exploratory clinical trial is to apply Unreal Engine 5 (UE5)-based Mixed Reality (MR) technology to achieve real-time stereoscopic visualization of surgical planning, personalized free flap harvest and…
- Conditions
- Tongue Squamous Cell Carcinoma, Mixed Reality, Virtual Surgical Planning, Free Flap
- Trial name
- NCT07466810
- Testing
- Unreal Engine 5 (UE5)-based Mixed Reality (MR) Technology-assisted Resection of Oral Cancer and Defect Reconstruction, Virtual Surgical Guide Technology-assisted Resection of Oral Cancer and Defect Reconstruction
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Oropharyngeal Cancer, Palate Free Flap Reconstruction
Functional Results of Soft Palate Free Flap Reconstruction
The oropharynx is a complex anatomical structure necessary for nasal breathing, swallowing and phonation. The removal of oropharyngeal cancers can lead to sequelae, particularly in the case of resections affecting the soft…
- Trial name
- RECaVoLL (NCT03890783)
- Testing
- Evaluation of phonation quality, Evaluation of swallowing quality, global quality of life questionnaire
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer
Opioid Free Versus Opioid Based Anaesthesia for Free Flap Reconstruction Surgery of the Breast: A Phase III Multicentric Randomized Controlled Study.
This study will compare morphine consumption during the first 48 hours postoperatively between the OFA group and the CA control group.
- Trial name
- OFOBA (NCT05439005)
- Testing
- Dexmedetomidine
- Where
- 3 sites in France
- Volunteers
- 158 people
- Sponsor
- Institut Curie
Deep Inferior Epigastric Artery Perforator Flap Breast Reconstruction
The Effect of Volatile Anesthesia and Total Intravenous Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Mastectomy and Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Free Flap
The aim of this study was to investigate the effects of total intravenous and inhalation anesthesia on the damage of endothelial glucocorticoids by comparing the concentration of syndecan-1 in patients undergoing mastectomy and…
- Trial name
- NCT05136508
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Mandibular Reconstruction, Dental Implant
Simultaneous Dental Implant in Free Vascularized Bone Flaps for Jaw Reconstruction
After jaw resection, free vascularized bone flaps are frequently used for repairing maxillofacial defects. Simultaneous dental implantation is more preferable to secondary implantation as it saves the patients from going through…
- Conditions
- Mandibular Reconstruction, Dental Implant, Free Tissue Flaps, Jaw Neoplasms
- Trial name
- NCT05405179
- Testing
- Simultaneous dental implantation
- Where
- Hong Kong
- Volunteers
- 25 people
- Sponsor
- The University of Hong Kong
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Use of a Non-ICU Specialty Ward For Immediate Post-operative Management of Head and Neck Free Flaps
Patients undergoing free flap reconstructive surgery at University of California, Davis Medical Center (UCDMC) will be assigned randomly into no intervention group (immediate post operative care in an ICU) or intervention group…
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Head and Neck Carcinoma, Trauma
- Trial name
- ICU (NCT03340038)
- Testing
- Non-ICU Specialty ward
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of California, Davis
Reconstructed Jaws, Free Fibula Flaps
Assessment of the Stability of Immediately Loaded All-on-four Dental Implants in FFF Used for Reconstruction of the Jaws
The use of free vascularized fibula flaps for bony reconstruction has proved its success as a substitution for the resected bone and in some instances, the surrounding soft tissues The aim of this case series study is to evaluate…
- Conditions
- Reconstructed Jaws, Free Fibula Flaps, All on Four Technique
- Trial name
- NCT03950284
- Testing
- immediate loading with all on four technique in FFF
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Cairo University
Head and Neck Cancer, Oral Cavity Cancer
Evaluation of the Benefit of a New Surgical Procedure According to IDEAL Recommendations for ORL Cancer Patients: the External Pudendal Flap Used as a New Free Flap for Oral Cavity/Oropharyngeal Reconstruction to Limit Donor Site Sequelae
This is a phase 1b, multicenter, non-randomized prospective study involving an innovation phase (IDEAL-1) followed by a prospective development phase (IDEAL-2A) designed to evaluate the safety and feasibility of…
- Conditions
- Head and Neck Cancer, Oral Cavity Cancer, Oropharynx Cancer
- Trial name
- LAMBEAU STEPA (NCT05757817)
- Testing
- Oropharyngeal or oral cavity reconstruction
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- Institut Claudius Regaud
Reconstructive Surgery After Carcinological Excision
Evaluation of the Interest of the Neurorrhaphy in Resensitizing Free Flaps
The surgical procedure consists in removing a tumor of the oral cavity and then repairing the oral defect by the use of a free flap.
- Trial name
- NCT03677349
- Testing
- neurorrhaphy
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Blood Flow, Anastomotic Failure of Flap
Effects of Vasopressor on the Graft Blood Flow in TRAM
The purpose of this pilot study is to investigate whether two major vasopressors (norepinephrine vs. phenylephrine) used for treatment of hypotension during breast reconstruction with free flap transfer surgery have different…
- Conditions
- Blood Flow, Anastomotic Failure of Flap, Flap Necrosis, Flap Ischemia
- Trial name
- NCT05049278
- Testing
- Norepinephrine, Phenylephrine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Cancer
Comparison of Harmonic Scalpel to Conventional Diathermy in Perforator Flap Elevation for Head and Neck Reconstruction
This study is to compare the efficacy of Harmonic Scalpel with conventional diathermy technique in terms of reducing elevation time and perioperative complications of perforator flaps for head and neck reconstruction.
- Trial name
- NCT01092468
- Testing
- Diathermy, Harmonic Scalpel
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Samsung Medical Center
Hemifacial Atrophy
Two- and Three-Dimensional Quantification of Facial Symmetry After Fat Grafting and Free Flap Reconstruction in Hemifacial Atrophy
Hemifacial atrophy causes one side of the face to become smaller, leading to facial asymmetry. Surgeons often restore facial volume using either autologous fat grafting or free-flap reconstruction.
- Trial name
- NCT07305909
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College
Bone and Joint Infection
Infection After Free Fibula Flap Reconstruction of the Mandible: a Retrospective Cohort Study
Mandibular osteitis after flap reconstruction is rare but is a serious infection with significant sequelae. The aim of this study is to describe this type of infection
- Trial name
- FibFlapI (NCT04373278)
- Testing
- failure of reconstruction of the mandibule by free fibula flap
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Trauma
Thoracodorsal Artery Perforator Flap Versus Conventional Free Flaps
The purpose of this study is to assess the efficacy of the thoracodorsal artery perforator flap versus other conventional free flaps for reconstruction of soft tissue defects.
- Trial name
- NCT03658603
- Testing
- thoracodorsal artery perforator flap, latissimus dorsi flap
- Volunteers
- 40 people
- Sponsor
- Assiut University
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Oropharynx Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma
Study Comparing Fibula Free-flap MR With or Without PVP in Patients With OOPC
This is a national multicenter, randomized, stratified, open label study, aiming to compare mandibular reconstruction (MR) with or without preoperative virtual planning (PVP), in patients with oral/oropharyngeal cancer (OOPC).
- Trial name
- CURVE (NCT04725396)
- Testing
- Mandibular Reconstruction (MR) with Preoperative Virtual Planning (PVP)., Conventional Mandibular Reconstruction (MR without PVP)
- Where
- 10 sites in France
- Volunteers
- 132 people
- Sponsor
- UNICANCER
Head and Neck Cancer
Oral Cancer With Wide Excision and Free Flap Reconstruction
A proactive speech-language pathologist program can be successfully established as part of the multidisciplinary care of patients with head and neck squamous cell carcinoma and improve patient quality of life.
- Trial name
- NCT03776578
- Testing
- swallow fuction and swallow training
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm
Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery
This trial studies the safety and how well negative pressure wound therapy works in healing the abdominal incision in obese patients undergoing free flap breast reconstruction surgery.
- Conditions
- Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm, Mammoplasty Patient, Obesity
- Trial name
- NCT04003038
- Testing
- Negative Pressure Wound Therapy, Wound Care Management
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer
Impact of Forearm Free Flap in Orbital Exenteration Reconstruction
Orbital exenteration is the en bloc removal of the entire orbital contents. This mutilating surgical technique is reserved for the management of certain malignant orbito-palpebral tumors or those that secondarily invade the…
- Trial name
- REXOR (NCT05255315)
- Testing
- Comparative analysis comparing the morbidity of the antebrachial free flap to that of the temporal flap flap during exenteration as well as the rate of fitting patients with epithesis.
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Institut Curie
Postoperative Pain Control, Opioid Consumption
Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery
The purpose of this study is to determine how a non-opioid pain control regimen, administered before and during surgery, will affect postoperative pain control and total opioid consumption in head and neck cancer participants…
- Trial name
- NCT04176419
- Testing
- Ketamine, Lidocaine, Acetaminophen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center