Clinical trials: Freezing of Gait
Parkinson Disease, Freezing of Gait
Split-belt Treadmill Training to Rehabilitate Freezing of Gait and Balance in Parkinson's Disease
Parkinson's disease (PD) related gait and balance disorders are challenging to treat because they cannot be optimized with pharmacological intervention alone.
- Conditions
- Parkinson Disease, Freezing of Gait, Gait, Unsteady
- Trial name
- NCT04946812
- Testing
- Split-belt treadmill training
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Toronto
Parkinson's Disease
Predictors of Motor Progression in Parkinson's Disease
Treatment resistant motor features, such as postural instability and freezing of gait are common in people with Parkinson's disease and major contributors to morbidity and mortality.
- Trial name
- NCT02769039
- Testing
- No intervention. Observational studies of sleep, movement and brain imaging
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson Disease
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking.
- Trial name
- NCT06911229
- Testing
- Deep Brain Stimulation (DBS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Parkinson Disease
Laser Light Visual Cueing for Freezing of Gait in Parkinson's Disease
The purpose of this study is to determine whether a laser light beam, attached to a rolling walker and projected onto the floor, reduces freezing episodes in patients with Parkinson's disease.
- Trial name
- NCT01502995
- Testing
- Laser light (U-Step Walking Stabilizer with laser light)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Parkinson's Disease Research, Education, and Clinical Center, Philadelphia
Parkinson Disease
Effects of Visual Biofeedback Therapy in Parkinson's Patients
Parkinson's disease (PD) affects approximately 6.5 million people around the world and it is ranked as the second most common age-related neurodegenerative disease after Alzheimer disease.
- Trial name
- NCT05325541
- Testing
- Visual Biofeedback Therapy, Conventional Balance exercise
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Ziauddin University
Parkinson Disease, Freezing of Gait
Decoding the Neural Mechanisms Underlying Postural Instability and Gait Dysfunction in Parkinson's Disease
The purpose of this study is to learn how brain signals are related to freezing of gait (FOG) and balance problems in Parkinson's disease (PD) and to study how different deep brain stimulation (DBS) settings may affect these…
- Trial name
- NCT07748962
- Testing
- Multiple Deep Brain Stimulation (DBS) Conditions, Moving Overground in a Virtual Environment (MOVE), Cleveland Clinic Stair Ambulation and Functional Evaluation of Gait (SAFE-Gait)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The Cleveland Clinic
Parkinson Disease
The Influence of Sensory Stimuli on Gait Imagery in Patients With Freezing of Gait
Background: Freezing of gait (FOG) is a common and very disabling symptom in people with Parkinson s disease, significantly affecting their quality of life.
- Trial name
- NCT01071590
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Freezing of Gait Symptoms in Parkinson's Disease, Deep Brain Stimulation
Imaging Biomarkers of FOG Response to DBS
For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS).
- Trial name
- NCT06951906
- Testing
- fMRI
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Medical University of South Carolina
Parkinson Disease
The Use of Sensory or Motor Cues Using Electrical Stimulation to Reduce Gait Freezing in Patients With Parkinson Disease
Some individuals with Parkinson disease experience "freezing" during walking which results in their inability to move their feet. They often have difficulty starting to move once they have stopped.
- Trial name
- NCT00762814
- Testing
- Gait tests with and without the use of a tactile sensory cue (electrical stimulation using a TENS unit)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Washington University School of Medicine
Parkinson's Disease
The Effect of Low-frequency rTMS on Motor Function in PD Patients With Freezing of Gait
This study is a double blind comparative study examining the effectiveness of the rTMS treatment on Freezing of Gait (FOG) phenomenon in patients with Parkinson's disease.
- Trial name
- NCT02221544
- Testing
- Low-frequency repetitive Transcranial Magnetic Stimulation, rTMS maintenance
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson's Disease
Effect of Robot-assisted Gait Training on Freezing of Gait in Parkinson's Disease
Freezing of gait (FOG) is a common yet poorly understood motor symptom in persons with Parkinson's disease (PD). Previous studies have shown that bilateral uncoordinated gait and gait asymmetry are related to FOG, and that…
- Trial name
- NCT00819949
- Testing
- Lokomat
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- US Department of Veterans Affairs
Parkinson Disease
The Efficacy and Mechanism of SMA+M1 Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in PD
This study is a double-blinded randomized study examining the efficacy of the double-site (M1+SMA) repetitive transcranial magnetic stimulation on Freezing of Gait (FOG) in patients with Parkinson's disease.
- Trial name
- NCT06415682
- Testing
- SMA+M1 Transcranial Magnetic Stimulation, M1 Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson Disease
Comparison of Sensory Cuing Modalities for Freezing of Gait
The investigators intend to compare the effects on the resolution of visual and auditory sensory cues on the resolution of freezing of gait in patients with idiopathic Parkinson's disease.
- Trial name
- NCT05080413
- Testing
- Laser shoes, Metronome
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Veterans Health Service Medical Center, Seoul, Korea
Parkinson's Disease, Multiple System Atrophy
Exploit the Neural Source and the Feasibility of Transcranial Direct Current Stimulation for Freezing of Gait in Parkinson's Disease and Multiple System Atrophy
In this project, the investigators will deliver a 5-day session of transcranial direct current stimulation (tDCS) to the leg motor cortex of the FOG patients to examine whether the intervention will benefit the patients in a…
- Trial name
- NCT03721887
- Testing
- Transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Parkinson Disease, Gait Disorders, Neurologic
Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease
The purpose of this study is to assess how alternating-frequency Deep Brain Stimulation (DBS) works to improve postural instability and gait, while also treating other motor symptoms of Parkinson Disease (PD).
- Conditions
- Parkinson Disease, Gait Disorders, Neurologic, Disease Progression, Subthalamic Nucleus
- Trial name
- ENGAGE-PD (NCT05022147)
- Testing
- High-Frequency-Only Stimulation, Low-Frequency-Only Stimulation, Alternating, 50 sec High-Frequency, 10 sec Low-Frequency Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- James Liao
Parkinson's Disease
Efficacy Study of Amantadine to Treat Gait Dysfunction and Freezing in Parkinson's Disease
The purpose of this study is to explore the efficacy of the drug Amantadine for the treatment of freezing of gait in patients with Parkinson's Disease.
- Trial name
- NCT01652534
- Testing
- Amantadine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Parkinson Disease
Effects of Routine Physical Therapy With and Without Proprioceptive Neuromuscular Facilitation on Balance, Gait and Function in Patients With Parkinson's Disease
Objective of this study is to compare the effectiveness of routine physical therapy with and without Proprioceptive Neuromuscular Facilitation on Balance, gait and function in patients with Parkinson's disease.
- Trial name
- NCT05154552
- Testing
- Proprioceptive Neuromuscular Facilitation, Routine physical therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Lahore
Parkinson's Disease With Freezing of Gait
Validation of cueStim for Reduction of Freezing of Gait in Parkinson's Disease
The goal of this clinical trial is to learn if the cueStim device can reduce the duration of freezing of gait (FoG) that occurs in patients with Parkinson's Disease.
- Trial name
- NCT07675408
- Testing
- CueStim
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Fortis Medical Devices Limited
Parkinson's Disease, Gait Disorders, Neurologic
Study of Memantine for Gait Disorders And Attention Deficit In Parkinson's Disease
Along with cognitive and psychobehavioural disorders, gait disorders represent a major problem in the treatment of advanced Parkinson's disease (PD).
- Trial name
- FOGG-I (NCT01108029)
- Testing
- memantine
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Lille
Parkinson's Disease, Parkinsonism
Mobilaser Study to Help With People Who Are Having Problems With Their Gait
Does use of the Mobilaser reduce freezing of gait (FOG) and stride reduction in patients with Parkinson's disease and Parkinsonism.
- Trial name
- NCT01581645
- Testing
- Mobilaser
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mayo Clinic