Clinical trials: Frozen Embryo Transfer (FET)
Recurrent Implantation Failure, Infertility
Comparing FET Guided by ERA Vs Standard Timing in Patients with Recurrent Implantation Failure
The pregnancy rate of in vitro fertilisation (IVF) remains around 35% per transfer. Women who are not pregnant following several embryo transfers are regarded as having recurrent implantation failure (RIF), with one of the causes…
- Trial name
- NCT06762626
- Testing
- Frozen embryo transfer according to endometrial receptivity analysis result
- Where
- China
- Volunteers
- 734 people
- Sponsor
- The University of Hong Kong
In Vitro Fertilization, Frozen Embryo Transfer
Comparison of Thawing Embryos in Advance and on the Day of Transfer on Pregnancy Outcomes in FET Cycle
Respectively for patients with repeated transplant failure and routine patients, Thawing frozen embryos in advance (18h) to extend the duration of embryonic development or thawing embryos on the day of transfer in the frozen…
- Trial name
- NCT04455191
- Testing
- Thawing Embryos in Advance, Thawing Embryos on the Day of Transfer
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jinan Central Hospital
Tirzepatide, Frozen Embryo Transfer
Dual GIP/GLP-1 Receptor Agonist in Obese Women Before Frozen Embryo Transfer
To evaluate the efficacy and safety of Dual GIP/GLP-1 receptor agonist pretreatment on reproductive outcomes in obese women before frozen embryo transfer.
- Conditions
- Tirzepatide, Frozen Embryo Transfer, Obesity
- Trial name
- NCT07811895
- Testing
- Dual GIP/GLP-1 receptor agonist
- Where
- China
- Volunteers
- 1,510 people
- Sponsor
- RenJi Hospital
Infertility
Uterine Contractions and Mode of Progesterone in Frozen Embryo Transfer (FET) Cycles: Randomized Clinical Trial
When patients undergo in vitro fertilization (IVF), they often make more embryos than it is safe to transfer back in the womb all at once. These excess embryos are frozen and stored for future use.
- Trial name
- NCT02078869
- Testing
- Progesterone in oil, vaginal progesterone suppositories
- Volunteers
- 34 people
- Sponsor
- Toronto Centre for Advanced Reproductive Technology
Pregnancy Related, Infertility, Female
Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
To evaluate whether single euploid embryo transfer in NC without routinely administered LPS is non-inferior to NC with routinely administered LPS.
- Trial name
- NCT05969795
- Testing
- Transvaginal ultrasound, Serial serum LH, E2, P4, Progesterone 100 Mg Vaginal Insert
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
IVF, Frozen Embryo Transfer
A Randomized Trial Comparing the Live Birth Rate of Immediate Versus Delayed FET Following a Freeze-all Strategy
This randomized trial we aim to compare the live birth rate of immediate versus delayed FET replacing a single blastocyst in the first FET of the first stimulated IVF cycle following.
- Trial name
- FET (NCT04371783)
- Testing
- Immediate FET, Delayed FET
- Where
- China
- Volunteers
- 828 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Frozen Embryo Transfer, Hormone Replacement Therapy
Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles
To investigate the efficacy of dydrogesterone 30 mg compared to micronized vaginal progesterone 800 mg daily for luteal phase support in hormone replacement therapy frozen embryo transfer cycles, as confirmed by visualization of…
- Conditions
- Frozen Embryo Transfer, Hormone Replacement Therapy, Dydrogesterone, Infertility, Female
- Trial name
- REMODEL (NCT04758871)
- Testing
- Dydrogesterone 10 MG Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- CRG UZ Brussel
Infertility
Frozen Embryo Transfer (FET) in Natural Cycles or in Natural Cycles Controlled by Human Chorionic Gonadotropin (hCG) Administration
The rational of the study is to assess the implantation, pregnancy and live birth rates after the transfer of frozen- thawed embryos in natural cycles with spontaneous Luteinizing Hormone (LH)/Progesterone rise or in natural…
- Trial name
- FRET (NCT00809107)
- Testing
- HCG
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Subfertility, Pregnancy
A RCT Comparing Spontaneous Natural Cycles and Human Chorionic Gonadotrophin-induced Natural Cycles in FET
This is a randomized controlled trial on the comparison of the ongoing pregnancy rate in frozen-thawed embryo transfer cycles with spontaneous ovulation and hCG-induced natural cycles.
- Trial name
- NCT02197208
- Testing
- Daily monitoring of LH and E2, hCG induced natural cycle, ultrasound
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 300 people
- Sponsor
- The University of Hong Kong
Frozen Embryo Transfer
The Association Between Serum E2 and P on the Day of FET and the Pregnancy Outcome
The outcomes of frozen embryo transfer (FET) have substantially improved over the last decade, due to the improvements in the cryopreservation process, Artificial endometrial preparation is typically accomplished by the…
- Trial name
- FET (NCT04114500)
- Testing
- serum estradiol and progesterone
- Where
- Bahrain
- Volunteers
- 402 people
- Sponsor
- Al Baraka Fertility Hospital
Infertility, Female, Polycystic Ovary Syndrome
Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS)
To offer patients with oligomenorrhoea or amenorrhoea an alternative to frozen embryo transfer in an artificial cycle, endometrial preparation using letrozole may be a valuable option.
- Conditions
- Infertility, Female, Polycystic Ovary Syndrome, IVF, Ovulation Disorder
- Trial name
- LEFT (NCT04002635)
- Testing
- Letrozole, estradiol valerate
- Volunteers
- healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Assisted Reproductive Technology, Ultrasonography
Evaluating the Endometrial Receptivity of FET Patient by Ultrasounicelastography
Prospective clinical study ：observing the correlation between endometrial elasticity score, endometrial blood flow index (PI, RI, S/D, endometrial thickness, morphology) and clinical pregnancy rate.
- Trial name
- NCT03881072
- Testing
- Ultrasounicelastography
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Infertility, Female
Personal FET in RIF Patients According to Histological Dating of Endometrial of Natural/ Hormone Replacement Cycle
At present, the evaluation criterion of endometrial receptivity is controversial. The development of a molecular diagnostic tool, the endometrial receptivity array (ERA) for diagnosis of endometrial receptivity .
- Trial name
- NCT03312309
- Testing
- personal embryo transfer
- Where
- China
- Volunteers
- 155 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Miscarriage, Frozen Embryo Transfer
Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients
The aim of the current study is to compare miscarriage rates (before 8 weeks) between a true natural cycle (awaiting spontaneous LH surge) and a hormone replacement therapy cycle prior to blastocyst transfer in preimplantation…
- Conditions
- Miscarriage, Frozen Embryo Transfer, Natural Cycle, Hormone Replacement Therapy Cycle
- Trial name
- NCT03976544
- Testing
- Estradiol Valerate, Micronized progesterone
- Where
- Belgium
- Volunteers
- 362 people
- Sponsor
- CRG UZ Brussel
Infertility, Polycystic Ovarian Syndrome
HRT Versus MOS for Endometrial Preparation Prior to FET in PCOS Patients
Evaluation of endometrial preparation using either hormonal therapy or ovarian stimulation prior to frozen-thawed embryo transfer (FET) in patients with polycystic ovarian syndrome (PCOS)
- Trial name
- NCT02273791
- Testing
- Estradiol valerate, Sequential Clomiphene citrate and Gonadotropin
- Where
- 2 sites in Egypt
- Volunteers
- 126 people
- Sponsor
- Mansoura University
Infertility, Endometrial Peristalsis
Endometrial Peristalsis and Pregnancy Outcomes in Hormone Replacement Therapy (HRT) - Frozen Embryo Transfer (FET) Cycles
Endometrial peristalsis may influence embryo implantation and pregnancy outcomes, but its role during hormone replacement therapy (HRT)-prepared frozen embryo transfer (FET) cycles remains unclear.
- Conditions
- Infertility, Endometrial Peristalsis, Uterine Contraction, Endometrial Waves
- Trial name
- CONCO (NCT07675213)
- Testing
- Endometrial peristalsis and hormone measurements
- Where
- Vietnam
- Volunteers
- 442 people
- Sponsor
- Mỹ Đức Hospital
Infertility
Frozen Embryo Transfer With GnRH-antagonist Trial
The fertility treatment in vitro fertilisation (IVF), sometimes including intra-cytoplasmic sperm injection (ICSI), involves the creation of embryos in a laboratory.
- Trial name
- NCT03763786
- Testing
- Cetrorelix Acetate
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Oxford
Infertility, Female
Progesterone-modified Natural Cycle for FET
Hormone replacement therapy (HRT) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (NC).
- Trial name
- COMPROSET (NCT06644794)
- Testing
- Progesterone-modified natural cycle preparation for frozen embryo transfer, Hormone replacement therapy cycle preparation for frozen embryo transfer
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Shandong University of Traditional Chinese Medicine
Adenomyosis of Uterus, Frozen Embryo Transfer (FET)
GnRH Agonist Pretreatment Duration and Letrozole Supplementation in Frozen Embryo Transfer for Adenomyosis Patients
This randomized clinical trial aims to assess the comparative effectiveness of different pre-treatment protocols prior to frozen embryo transfer (FET) among women with adenomyosis, providing evidence-based guidance for clinical…
- Trial name
- GOLD-FET (NCT07065539)
- Testing
- GnRH-a-1M, GnRH-a-2M, GnRH-a+LE-1M
- Where
- China
- Volunteers
- 432 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Infertility
Vaginal Compared to Intramuscular Progesterone for Frozen Embryo Transfer
To determine whether the of vaginal progesterone replacement for frozen embryo transfer results in equivalent live birth rates to intramuscular injection progesterone replacement.
- Trial name
- NCT02254577
- Testing
- Endometrin® plus Progesterone in Oil (PIO), Progesterone in Oil (PIO) Only
- Where
- 14 sites in United States
- Volunteers
- 1,139 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center