Clinical trials: Fructose Metabolism Disorder
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
Fructose Breath-testing in Irritable Bowel Syndrome (IBS)
Background: Breath testing for food intolerances is becoming routine in patients with functional gastrointestinal disorders (FGID).
- Trial name
- NCT02614313
- Testing
- Open breath test with fructose, Blinded breath test with fructose
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brain-Gut Research Group
Non-alcoholic Fatty Liver Disease
Fructose and Liver Diseases in Youth: Help Them FLY
Obesity has been increasing all over the world. This has lead to a significant increase of a liver disease in children called non-alcoholic fatty liver disease (NAFLD).
- Trial name
- FLY (NCT05528471)
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Uric Acid Concentration, Serum, Quantitative Trait Locus 7
Effect of Losartan or Eprosartan on Fructose Hyperuricemia
Hyperuricemia is seen in about 20% of adults in the general population, Chronic hyperuricemia, frequently manifesting as the gout, is a well-known risk factor of joint damage but has been also linked to a variety of other…
- Trial name
- metabolic (NCT04954560)
- Testing
- losartan and eprosartan
- Volunteers
- 16 people
- Sponsor
- Medical University of Lodz
Pre-diabetes
Anti-hyperglycemic Effect of Short-term Arginyl-fructose Supplementation in Subjects With Pre-diabetes and Newly Diagnosed Type 2 Diabetes: Randomized, Double-blinded, Placebo-controlled Trial.
In this double-blind, placebo-controlled study, subjects with prediabetes and type 2 diabetes were randomly assigned to the placebo control group or the test (Arginyl-fructose: AF) group.
- Trial name
- NCT02285231
- Testing
- Arginyl-fructose
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Type 2 Diabetes
Effect Dietary Fructose on Fructose Kinetics in Type 2 Diabetes
Determine the kinetics of fructose metabolism and its role as a metabolic substrate following a high (100gr/day) vs low fructose diet (<30 gram fructose intake per day isocaloric correction with dextrose) in type 2 diabetic…
- Trial name
- ERIE (NCT05717608)
- Testing
- high vs low fructose in caucasian dutch or surinamese asian type 2 diabetes subjects
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Healthy
Fructose and Ethnic Differences Study (FED Study)
In the UK, people of black West African and Caribbean's tend to have healthier blood cholesterol and blood fat levels, as well as lower incidence of heart disease/heart attack.
- Trial name
- FED (NCT02533817)
- Testing
- Dietary sugar
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King's College London
Overweight and Obesity, Metabolic Syndrome
The Role Of Fructose and Uric Acid In the Development of Obesity and Metabolic Syndrome
The purpose of this study is to determine if a low fructose intake could have an impact on weight loss, uric acid levels and the components of the metabolic syndrome (glucose, cholesterol, triglycerides, insulin resistance, high…
- Conditions
- Overweight and Obesity, Metabolic Syndrome, Hyperuricemia
- Trial name
- NCT00868673
- Testing
- low fructose, Normal fructose arm
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Overweight, Obesity
Meta-analyses of Total and Individual Fructose-containing Sugars and Incident Cardiometabolic Disease
Since uncontrolled observational studies first linked fructose to the epidemic of obesity almost a decade ago, it has become a focus of intense concern regarding its role in the obesity epidemic and increasing burden of…
- Conditions
- Overweight, Obesity, Dyslipidemia, Hyperlipidemia
- Trial name
- NCT01608620
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Test Meal
Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP)
In parallel to the dramatic rise in metabolic diseases and diabetes observed over the past fifty years, the generalization of added sugar in processed food led to a marked increase in fructose consumption in almost all countries…
- Trial name
- FruPP (NCT03195062)
- Testing
- Test meal
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Small Intestinal Bacterial Overgrowth, Lactose Intolerance
Clinical Utility of Breath Tests in GI
Bloating, gas, pain and diarrhea are common complaints. Routine investigations are negative; these patients are labeled as IBS. In these patients, whether testing for carbohydrate malabsorption or small intestinal bacterial…
- Conditions
- Small Intestinal Bacterial Overgrowth, Lactose Intolerance, Fructose Intolerance, Glucose Intolerance
- Trial name
- NCT03261856
- Where
- United States
- Volunteers
- 1,080 people
- Sponsor
- Augusta University
Metabolic Syndrome X, Liver Diseases
Effects of Macronutrients on Hepatic Lipids, Plasma Triglycerides, and Insulin Sensitivity
The purpose of this study is to assess how the macronutrient composition of the diet effects lipid and glucose metabolism intrahepatic lipids insulin sensitivity in healthy lean subjects and in subjects with a high metabolic risk…
- Trial name
- MACRONUTR (NCT00523562)
- Testing
- diet intervention
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Vascular Diseases
Vascular and Metabolic Consequences of Adopting a Westernized Lifestyle
The purpose of this study is to determine if short-term adoption of a Westernized lifestyle characterized by physical inactivity and increased consumption of fructose will result in metabolic and vascular dysfunction.
- Trial name
- NCT03785470
- Testing
- Fructose and physical inactivity
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Non-Alcoholic Fatty Liver Disease, Obesity
Impact of Short-term Fructose-enriched Diet on Serum Metabolome by Normal- and Over-weighed Women.
The purpose of this study is to investigate how a high-fructose diet, either by high fructose intake from complex, natural foods or by fortifying the diet with corn syrup, affects the metabolism.
- Trial name
- NCT03444233
- Testing
- Diet
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Critical Illness
Glycemic Index Variation During Low-carbohydrate Enteral Formula With and Without Fructose in Critically Ill Patients
Hyperglycemia is a known risk factor for mortality in critically ill patients. Most of these patients receive enteral feeding. There is controversy about ideal carbohydrate composition of these diets.
- Trial name
- NCT03003507
- Testing
- Enteral Formula With Fructose, Enteral Formula Without Fructose
- Volunteers
- 25 people
- Sponsor
- Hospital Moinhos de Vento
Prediabetes
Effect of Inulin-type Fructose Extracted From Jerusalem Artichoke on Improving Prediabetic State of Type 2 Diabetes
The trial was a multicenter, randomized, double-blind, placebo-controlled, parallel-controlled, exploratory clinical study.Through the intervention of soluble dietary fiber in the pre-type 2 diabetic population, the change of…
- Trial name
- NCT03794232
- Testing
- NIUCHANG
- Volunteers
- 246 people
- Sponsor
- Inuling (Bei Jing) Science and Technology Co. Ltd
PreDiabetes, Diabetes Mellitus
Dried Fruit and Postprandial Glycemia Trial
Dried fruits show promising potential for the management of blood glucose. Previous trials have reported beneficial effects of raisins on post-prandial glucose and insulin responses in healthy individuals when compared with white…
- Conditions
- PreDiabetes, Diabetes Mellitus, Dysglycemia
- Trial name
- NCT02960373
- Testing
- White Bread (Control), Dried Fruit - Glycemic Index, Catalytic Fructose Dose Effect
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes Mellitus (T2DM)
A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM
To evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of ALN-KHK and to evaluate the safety, tolerability, efficacy, PK and PD of multiple doses of KHK.
- Trial name
- NCT05761301
- Testing
- ALN-KHK
- Where
- 15 sites in United States, Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Alnylam Pharmaceuticals
Nonalcoholic Fatty Liver Disease, Glucose Metabolism Disorders
Effects of Fructose Restriction on Liver Steatosis
Nonalcoholic fatty liver disease (NAFLD) is an emerging health problem as it can lead to end stage liver failure and cardiovascular complications. Diet play an important role in the development of NAFLD.
- Conditions
- Nonalcoholic Fatty Liver Disease, Glucose Metabolism Disorders, Endothelial Dysfunction
- Trial name
- FRUITLESS (NCT03067428)
- Testing
- Glucose, Fructose
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Glycogen Storage Disease Type I
Dietary Treatment Strategies and Metabolic Control in Glycogen Storage Disease Type I
The present project will specifically assess metabolic effects of dietary interventions with controlled intake of fructose and fructose/galactose in GSDI, with the aim to provide evidence whether relaxed dietary restrictions of…
- Trial name
- GSD-DIET (NCT06852612)
- Testing
- Fructose, Fructose and galactose
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Fructose Intolerance
Investigation of Supplemental L-alanine in the Management of Dietary Fructose Intolerance
Over the past few decades, fructose consumption has risen significantly in the United States1. This sugar is increasingly being used as a sweetener in a variety of foods1.
- Trial name
- NCT04022434
- Testing
- Placedo, Alanine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Augusta University