Clinical trials: Fructose Metabolism Disorder
Insulin Resistance
BaRiatric Surgery AnD FRUctose Handeling In Obese subjecTs
To investigate whether changes in fructose dietary intake can help to improve dietary fructose-induced insulin resistance and post bariatric weight loss in obese subjects of Caucasian descent
- Trial name
- BREADFRUIT (NCT05717595)
- Testing
- fructose
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Overweight, Obesity
Meta-analysis of Fructose-Containing Sugar Sweetened Beverages (SSBs) and Weight Change
Since uncontrolled observational studies first linked fructose to the epidemic of obesity almost a decade ago, it has become a focus of intense concern regarding its role in the obesity epidemic.
- Conditions
- Overweight, Obesity, Diabetes, Prediabetes
- Trial name
- NCT01608607
- Testing
- Fructose-containing sugar sweetened beverages
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
MASLD, Type 2 Diabetes
High Fructose Diet, the Gut Microbiome, and Metabolic Health
Americans commonly consume excess amounts of dietary fructose. Added fructose has been shown to have an adverse impact on metabolic health, including increased insulin resistance and type 2 diabetes (T2D) risk.
- Conditions
- MASLD, Type 2 Diabetes, Obesity
- Trial name
- NCT06329544
- Testing
- Fructose, glucose
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pediatric Obesity
Dietary Fructose: a Metabolic Switch in Pediatric Obesity-related Disease.
The increase in childhood obesity is a multifactorial phenomenon influenced by dietary patterns, commercial factors, and social determinants; it has long-term consequences for both individual health and society as a whole.
- Trial name
- EO2022 (NCT06365567)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Hyperglycaemia (Diabetic)
Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose
To investigate whether longer-term improvement of glycemic control in poorly controlled diabetes patients with a 12-week intensified insulin treatment regimen will lead to decreased polyol pathway activity.
- Trial name
- NCT03469492
- Testing
- Insulin, exercise, Dietary counseling
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Acute Ischemic Stroke
Fructose for Acute Ischemic Stroke
This is a single-center, prospective, randomized, open-label, blinded-endpoint exploratory clinical study enrolling 46 patients with acute ischemic stroke.
- Trial name
- FRUCTOSE-AIS (NCT07626541)
- Testing
- 10% Fructose Injection
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ji Xunming,MD,PhD
Body Weight, Obesity
Meta-analyses of Food Sources of Fructose-Containing Sugars and Obesity
Sugars have been implicated in the epidemics of overweight and obesity. This view is supported by lower quality evidence from ecological observations, animal models, and select human trials.
- Conditions
- Body Weight, Obesity, Overweight, Adiposity
- Trial name
- NCT02558920
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Functional Gastrointestinal Disorders, Lactose Intolerance
Fructose and Lactose Intolerance and Malabsorption in Functional Gastrointestinal Disorders
Background: The association of fructose and lactose intolerance and malabsorption with the symptoms of different functional gastrointestinal disorders (FGID) is unclear.
- Conditions
- Functional Gastrointestinal Disorders, Lactose Intolerance, Fructose Intolerance
- Trial name
- NCT02085889
- Testing
- no intervention: observational study
- Where
- Switzerland
- Volunteers
- 3,000 people
- Sponsor
- Brain-Gut Research Group