Clinical trials: Fulminant Liver Failure
Acute Liver Failure
Etiology and Prognostic Factors in Patients With Acute Liver Failure
Acute liver failure (ALF) is a rare but life-threatening condition with high mortality. Despite advances in supportive care and liver transplantation, prognosis varies significantly across etiologies, particularly in patients…
- Trial name
- NCT07556055
- Volunteers
- 400 people
- Sponsor
- Li-Ying Sun
Acute Liver Failure
Plasma Exchange for Amanita Toxin-induced Acute Liver Failure
Retrospective evaluation of the value of additive therapeutic plasma exchange (PEX) compared to standard medical therapy (SMT) in Amanita toxin-associated acute liver failure in children and adolescents within the last 10 years…
- Trial name
- Amanita-Pex (NCT06187220)
- Testing
- Therapeutic Plasma Exchange (PEX)
- Where
- 6 sites in Germany, Italy and 3 more
- Volunteers
- 111 people
- Sponsor
- Hannover Medical School
Acute Liver Failure
13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF
The ALFSG-MBT protocol is for a multicenter, open label, non-randomized study to determine the value of Breath Identification® (BreathID®) N-(4-Methoxy-13C-phenyl)acetamide (13C-Methacetin) Breath Test System in predicting the…
- Trial name
- ALFSG-MBT (NCT02786836)
- Testing
- 13C-Methacetin
- Where
- 11 sites in United States
- Volunteers
- 76 people
- Sponsor
- University of Texas Southwestern Medical Center
Liver Failure, Acute
Safety and Efficacy of hiHep Bioartificial Liver Support System to Treat Acute Liver Failure
This study tend to evaluate safety and efficacy of hiHep bioartificial liver support system in treating acute liver failure.
- Trial name
- NCT03084198
- Testing
- hiHep Bioartificial Liver Support System, Standard care for ALF
- Volunteers
- 16 people
- Sponsor
- Shanghai East Hospital
Acute Liver Failure, Sepsis
Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis
Context Acute liver failure (ALF) is a life-threatening condition that occurs on the background of a healthy liver. The most common cause of acute liver failure in the UK is paracetamol overdose.
- Trial name
- MAP-ALF (NCT07131969)
- Testing
- blood draw
- Where
- 7 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Cambridge
Acute Liver Failure, Hepatic Encephalopathy
N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure
We have completed patient enrollment in the the double blind, randomized, placebo-controlled trial of intravenous (IV) N-acetylcysteine (NAC) vs. placebo for the treatment of non-acetaminophen ALF.
- Trial name
- NCT00248625
- Testing
- N-acetylcysteine
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 184 people
- Sponsor
- University of Pittsburgh
Acute Liver Failure
Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen
OBJECTIVES: I. Determine the safety and efficacy of a short course (72 hours) of intravenous acetylcysteine in patients with acute liver failure for whom no antidote or specific treatment is available.
- Trial name
- NCT00004467
- Testing
- N-acetylcysteine (NAC)
- Where
- 25 sites in United States
- Volunteers
- 173 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Acute Liver Failure, Acute Liver Injury
Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury
This Phase 2a clinical study is designed to provide data on OCR-002 in patients with acute liver failure/acute liver injury (ALF/ALI) in regard to: safety and tolerability; metabolism of the compound to glutamine and…
- Trial name
- STOP-ALF (NCT01548690)
- Testing
- Ornithine Phenylacetate
- Where
- 11 sites in United States
- Volunteers
- 47 people
- Sponsor
- William Lee
Acute Liver Failure, Acute-On-Chronic Liver Failure
Role of Fecal Microbiota in Predicting Graft Rejection and Sepsis Among Recipients of Living Donor Liver Transplant in First Year.
Efficient immunosuppressive therapy and improved surgical techniques have developed liver transplantation as a well-established and life-saving treatment. The 1-year survival rate of approximately 85-90%.
- Conditions
- Acute Liver Failure, Acute-On-Chronic Liver Failure, Liver Cirrhosis
- Trial name
- NCT04621812
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Fulminating Hepatic Failure
Patients' Outcome With Severe or Fulminant Hepatic Insufficiency, Hospitalized in the Public Hospitals of Paris
The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe, fulminating acute liver failure in the public hospitals of paris.
- Trial name
- DEVINHEF (NCT04658407)
- Where
- France
- Volunteers
- 18,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Failure Acute
Hepatocyte Transplantation for Acute Decompensated Liver Failure
The purpose of this research study is to determine whether liver cell transplantation can provide help for patients with liver failure who are unlikely to survive without some form of liver support.
- Trial name
- NCT01345565
- Testing
- human hepatocytes
- Where
- United States
- Sponsor
- Ira Fox
Hepatitis A, Acute Hepatitis
Risk Factors and Outcomes of Hepatitis A in Children
This prospective observational study aims to evaluate the risk factors, clinical course, and outcomes among children with acute hepatitis A infection admitted to Assiut University Children Hospital.
- Trial name
- NCT07848321
- Volunteers
- 190 people
- Sponsor
- Assiut University
Acute Liver Failure
Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure
The purpose of the study is to determine whether L-Ornithine L-Aspartate infusion improves the survival of patients with acute liver failure.
- Trial name
- NCT00470314
- Testing
- L-Ornithine L-Aspartate
- Where
- India
- Volunteers
- 150 people
- Sponsor
- All India Institute of Medical Sciences
Liver Failure, Acute
Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis
Granulocyte colony stimulating factor in acute liver failure and alcoholic hepatitis
- Trial name
- G-CSF (NCT01341951)
- Testing
- Granulocyte colony stimulating factor
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh