Clinical trials: Functional Aging
Treatment, Placebo
The Cognitive Enhancing Effects of D-Cycloserine Among Non-Demented Elderly
The goal of this study is to determine whether a study medication (d-cycloserine) improves the ability of older adults to perform on tests of neuropsychological functioning.
- Trial name
- NCT01361633
- Testing
- d-cycloserine, Sugar Pill
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Aging
Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly
The ability to mount an effective immune response declines with age, leaving the elderly increasingly susceptible to infectious diseases and cancer.
- Trial name
- NCT02874924
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Frailty, Sarcopenia
FrAilty Care and wEll-funcTion in Community Dwelling Older Adults
This study is looking at whether older people could benefit from an online monitoring platform to support their individual ambitions to maintain or improve functional ability.
- Conditions
- Frailty, Sarcopenia, Aging
- Trial name
- FACET (NCT03707145)
- Testing
- Consultation, Online Support, Empowered
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
Mitochondrial Function, Physical Function
Resveratrol to Enhance Vitality and Vigor in Elders
Resveratrol, a compound found in red wine and dark-skinned grapes, will improve the function of mitochondria (energy producing components) within the leg muscles of moderate functioning older adults.
- Trial name
- REVIVE (NCT02123121)
- Testing
- Resveratrol 1000 mg/day, Resveratrol 1500 mg/day, Vegetable cellulose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Endothelial Dysfunction, Aging
Passive Mobilization and Vascular Function
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF.
- Conditions
- Endothelial Dysfunction, Aging, Bed Rest
- Trial name
- NCT03087643
- Testing
- Passive mobilization - PM
- Where
- 3 sites in Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Aging, Sarcopenia
Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals
Nitrate is a naturally-occurring substance found in foods, especially green leafy vegetables and beets. Increasing nitrate intake (by drinking beetroot juice (BRJ) has been shown to improve muscle function young and middle-aged…
- Trial name
- NCT03595774
- Testing
- Beet root juice
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Indiana University
Older Adults, Physical Function
Curcumin and Function in Older Adults
This placebo-controlled RCT tests whether dietary supplementation with curcumin maintains or improves cognitive and physical function in older adults who are at high risk of functional decline due existing (mild) functional…
- Conditions
- Older Adults, Physical Function, Cognitive Function
- Trial name
- SPICE (NCT03085680)
- Testing
- Curcumin, microcrystalline cellulose
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Florida
Older Adults, Mental Health
The BE WITH Project: A Partially Nested Randomized Control Trial (PN-RCT)
The goal of this clinical trial is to learn if the BE WITH (Belonging through Empathy With Intentional Targeted Helping) innovation delivered to older adults improves their mental health.
- Conditions
- Older Adults, Mental Health, Depression, Loneliness
- Trial name
- BE_WITH (NCT07204444)
- Testing
- standardized and manualized warm calls from providers trained in the BE training, standardized and manualized warm calls from providers trained in the BE training + ASIST training
- Where
- United States
- Volunteers
- 671 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aging, Healthy
ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly
The purpose of the ACTIVE study was to test if cognitive training interventions could maintain functional independence in elders by improving basic mental abilities, with follow-up assessments through five years.
- Trial name
- ACTIVE (NCT00298558)
- Testing
- Cognitive Training
- Where
- 7 sites in United States
- Volunteers
- 2,832 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Obesity, Sarcopenia
Biological Effects of Weight Loss In Older, Obese Women
Obesity and sedentary lifestyle are associated with physical impairments and biological changes in older adults. Weight loss combined with exercise may reduce inflammation and may improve physical functioning in older adults who…
- Trial name
- WL+E (NCT01032733)
- Testing
- Lifestyle Counseling, Educational Control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy Volunteers
Dose-Response of Gonadal Steroids and Bone Turnover in Older Men
The purpose of this study is to determine the levels of testosterone and/or estradiol at which changes in bone turnover, body composition, strength, sexual function etc. begin to occur in older men.
- Trial name
- NCT00114114
- Testing
- Testosterone, Goserelin acetate
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Glucose Intolerance, Aortic Stiffness
Healthy Aging Through Functional Food
The purpose of this study is to determine whether dietary inducers of glyoxalase 1 are effective in improving metabolic and vascular health.
- Conditions
- Glucose Intolerance, Aortic Stiffness, Vasodilation
- Trial name
- HATFF (NCT02095873)
- Testing
- Glyoxalase 1 (Glo1) inducer
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Warwick
HIV Infections
Aging & HIV/AIDS Neurocognitive Sequelae and Functional Consequences
While the numbers of HIV infected veterans under the age of 50 are declining, the percentage of HIV infected veterans over the age of 50 is increasing with the largest percentage increases in the 50-59 age group and the 70+ age…
- Trial name
- NCT00675766
- Where
- United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Accidental Falls
Intervention to Enhance Lateral Balance Function and Prevent Falls in Aging
Falls and their consequences are among the major problems in the medical care of older individuals. The long-term goal of this research is to establish the efficacy of a scientifically grounded and mechanism-based therapeutic…
- Trial name
- LIFT (NCT01370174)
- Testing
- Physical Training Interventions
- Where
- 2 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Sarcopenia
Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults
The investigators recently published significant associations between circulating gut bacteria-related metabolites with lean and skeletal muscle mass and with measures of physical function in older adults, evidence that suggests…
- Trial name
- NCT02811445
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tufts University
Arterial Stiffening, Aging
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
The purpose of this study is to find out why women's arteries stiffen as they go through menopause, and how this is affected by estrogen loss.
- Conditions
- Arterial Stiffening, Aging, Menopause
- Trial name
- SHAPE (NCT00608062)
- Testing
- GnRHant - Ganirelix acetate, Transdermal estradiol patch
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sarcopenia, Aging
Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults
The loss of muscle mass and strength due to aging leads to serious health problems for older adults. Muscle health can be improved by exercise training, but some people improve their strength substantially, whereas others improve…
- Conditions
- Sarcopenia, Aging, Immune Function
- Trial name
- TDAP2 (NCT02261961)
- Testing
- TDAP, Acute Resistance Exercise, Resistance Exercise Training
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Neuromuscular Function
Vitamin D Supplementation and Muscle Function in Older Adults
The purpose of this study is to see if vitamin D supplementation improves muscle function in older adults.
- Trial name
- EVIDENCE (NCT02015611)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Aging, Cognitive Aging
Impact of Music Improvisation Training on Cognitive Function in Older Adults
This project will develop and test the effects and mechanisms of a music improvisation training intervention on self-regulation of older adults with and without MCI.
- Conditions
- Aging, Cognitive Aging, Cognitive Impairment, Cognitive Training
- Trial name
- NCT05980286
- Testing
- Piano Improvisation, Music Listening
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Memory Loss, Cognitive Changes
Aging and Estrogen on Cortical Function
This study will focus on how estrogen affects parts of the brain associated with memory and how the effect of estrogen is altered with aging in postmenopausal women.
- Conditions
- Memory Loss, Cognitive Changes, Postmenopausal Symptoms
- Trial name
- NCT01268046
- Testing
- Estradiol oral capsule, transderman estrogen patch
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital