Clinical trials: Functional Aging
Cardiovascular Diseases, Aging
Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults
This purpose of this study is to assess the impact of consuming wolfberry on cardiovascular risk in Singapore's middle-aged and older adults.
- Trial name
- NCT03535844
- Testing
- Wolfberry, Healthy diet
- Where
- 2 sites in Singapore
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Treatment, Placebo
The Cognitive Enhancing Effects of D-Cycloserine Among Non-Demented Elderly
The goal of this study is to determine whether a study medication (d-cycloserine) improves the ability of older adults to perform on tests of neuropsychological functioning.
- Trial name
- NCT01361633
- Testing
- d-cycloserine, Sugar Pill
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Mobility Disability, Older Adults
Community-based Functional Fitness for Adults Aging With Mobility Disability
Evaluate the feasibility and potential effectiveness of a 12-week, high-intensity functional training (HIFT) intervention on frailty in older adults (60+) with mobility disabilities (MD) who are ambulatory
- Trial name
- AAIMLCOA (NCT07283510)
- Testing
- Functional Fitness
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Mild Cognitive Impairment (MCI)
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
This research is being done to find out if daily use of the drug levetiracetam can improve memory function in individuals with memory problems like those associated with Mild Cognitive Impairment (MCI) and Alzheimer's disease…
- Trial name
- NCT01044758
- Testing
- Levetiracetam 62.5mg, Levetiracetam 125mg, Levetiracetam 250mg
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Aging, Muscle Strength
Effect of HMB Supplementation and Vivifrail Exercise on Body Composition, Handgrip Strength and Physical Performance in Women Over 60 Years of Age
The goal of this clinical trial is to learn whether taking a daily supplement of β-hydroxy-β-methylbutyrate (HMB) while following a structured exercise program improves body composition, muscle strength and physical performance…
- Conditions
- Aging, Muscle Strength, Physical Functional Performance, Body Composition
- Trial name
- NCT07905755
- Testing
- Calcium β-hydroxy-β-methylbutyrate (HMB-Ca), Vivifrail multicomponent exercise program
- Where
- Mexico
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad Autónoma del Estado de Hidalgo
Age-related Functional Decline
The Effects of Exercise Intervention on Skeletal Muscle and Other Organs in Aged Population and the Discovery of Associated Circulating Biomarkers
This project aims to investigate the intricate interplay between skeletal muscle and adipose tissue during the aging process by integrating human studies.
- Trial name
- NCT06660706
- Testing
- Multi-domain intervention
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Yang Ming Chiao Tung University
Healthy Aging, Cognitive Function 1, Social
Understanding Cerebral Blood Flow Dynamics for Alzheimer's Disease Prevention Through Exercise
Dementia is one of the leading causes of disability worldwide. Underlying biological mechanisms are crucial in preclinical stages of Alzheimer's disease (AD).
- Conditions
- Healthy Aging, Cognitive Function 1, Social, Cerebrovascular Circulation, Blood Flow
- Trial name
- flADex (NCT06584656)
- Testing
- Aerobic exercise condition, Resistance exercise condition
- Where
- 2 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Prediabetic State, Cardiovascular Diseases
Role of Aging and Individual Variation in Exercise Training Responsiveness
The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15…
- Conditions
- Prediabetic State, Cardiovascular Diseases, Insulin Resistance, Obesity
- Trial name
- STRRIDE IV (NCT06471569)
- Testing
- Low/Mod, High/Mod, High/Vig
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Mild Cognitive Impairment, Healthy Aging
A Novel Computer-Based Functional Skills Assessment and Training Program
People with cognitive impairments such as Mild Cognitive Impairment (MCI), often experience difficulty performing everyday routine activities.
- Trial name
- NCT04679441
- Testing
- The Computerized Functional Skills Assessment and Training Program, Brain HQ Double Decision
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- i-Function, Inc.
Aging, Functional Recovery
Advancing Rehabilitation Paradigms for Older Adults in Skilled Nursing Facilities
This cluster randomized clinical trial seeks to provide large-scale, foundational evidence that high-intensity rehabilitation is effective and can be systematically implemented to improve functional outcomes for patients admitted…
- Conditions
- Aging, Functional Recovery, Skilled Nursing Facility, Medically Complex
- Trial name
- NCT05492240
- Testing
- i-STRONGER, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 4,383 people
- Sponsor
- University of Colorado, Denver
Healthy, Cognitive Function 1, Social
Active Gains in Brain Using Exercise During Aging
AGUEDA (Active Gains in brain using Exercise During Aging) is a randomized controlled trial designed to examine the effects of a 24-week resistance exercise program on brain health in cognitively normal adults between 65-80 years…
- Trial name
- AGUEDA (NCT05186090)
- Testing
- 24-week resistance exercise program
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Hearing Loss, Functional
The Effectiveness of Over the Counter Hearing Products for Middle-Aged Adults
The investigators will examine the effectiveness of selected over-the-counter personal sound amplifiers in addressing functional hearing problems in middle-aged listeners with mild hearing loss.
- Trial name
- NCT03511417
- Testing
- over-the-counter hearing device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Aging
The Entorhinal Cortex and Aerobic Exercise in Aging
The overall goal of this study is to examine how regular exercise affects brain function, spatial memory, and virtual navigation. Participation in this research study will take approximately 4 months.
- Trial name
- ECE (NCT02775760)
- Testing
- Cardiovascular endurance, Strength, balance, and flexibility
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Boston University
Menopause, Estrogen Deficiency
Cardiometabolic Consequences of the Loss of Ovarian Function
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease.
- Conditions
- Menopause, Estrogen Deficiency, Aging, Adiposity
- Trial name
- LILAC (NCT06264882)
- Testing
- Degarelix, Transdermal Estradiol Patch
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Frailty Syndrome, Cognitive Impairment
Successful Aging and Frailty
Frailty is the term commonly utilized to describe the geriatric syndrome that exposes the elderly to increased risk of negative health-related events.
- Conditions
- Frailty Syndrome, Cognitive Impairment, Sarcopenia
- Trial name
- SAFe (NCT03963050)
- Testing
- Exercise Training, Exercise Training + Cognitive Training, Control
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Older People, Sports
Boxing, Taekwondo and Elastic Band Training on Body Composition and Physical Performance in Older Women
The objective of this clinical trial is to compare the effect of three physical interventions (Taekwondo, Boxing, and Elastic Band Training) on body composition and physical performance in older Chilean women.
- Conditions
- Older People, Sports, Martial Arts
- Trial name
- RCT (NCT06780020)
- Testing
- Effects of different interventions using boxing, Effects of different interventions using taekwondo, Effects of different interventions using Elastic Band
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Católica del Maule
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Sarcopenia
Effects of L-ARGinine and Liposomal Vitamin C Supplementation On Physical Performance
In older age, reduced mobility is associated with an increased risk of reduced quality of life, disability, institutionalisation, and death, as well as increased healthcare expenditures.
- Trial name
- ARGO (NCT06865261)
- Testing
- Bioarginina C
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Estrogen, Premenopause
Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women
The purpose of this study is to identify the impact of estradiol (E2) on the associations between (a) responsivity to daily stress or (b) sleep variability with vascular function in midlife premenopausal women.
- Trial name
- V-RISES (NCT06745466)
- Testing
- ganirelix acetate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Healthy Aging, Cognitive Decline
Cognitively Enriched Walking Program
Dementia currently affects more than 47 million people worldwide, its prevalence is forecasted to triple by 2050, and it has been reported to be one of the most costly disorders in Belgium.
- Conditions
- Healthy Aging, Cognitive Decline, Physical Inactivity
- Trial name
- NCT05500183
- Testing
- Cognitively enriched walking program, walking program
- Where
- 2 sites in Belgium
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Ghent