Clinical trials: Functional Aging
Aging
Activity, Gait, and Efficacy (AGE II): Functional Limitations and Quality of Life
The purpose of this study is to test the effectiveness of a DVD-delivered, home-based, six-month physical activity intervention for older adults.
- Trial name
- AGE II (NCT01030419)
- Testing
- Home-based, DVD-delivered physical activity, Usual care/Wait list
- Where
- United States
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Healthy Diet, Healthy Aging
Acute Effects of Added Sugar Intake on Cerebrovascular Function and Brain Integrity
This study will focus on acute effects of added sugars on brain health in a specific age group (30-64 years old). We will provide participants two meals (one meal containing 16 g of added sugars and the other containing 61 g of…
- Trial name
- NCT05408338
- Testing
- Low Added Sugar Meal, High Added Sugar Meal
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Cognitive Ability, General, High Blood Pressure
Assessing the Impact of Calcium Channel Blockers on COGnitive Function in the Very Elderly (AI-COG)
Older adults are at increased risk of high blood pressure and cognitive decline. High blood pressure itself also increases risk of cognitive decline.
- Trial name
- NCT01868165
- Where
- 7 sites in United Kingdom
- Volunteers
- 337 people
- Sponsor
- Imperial College London
Healthy Aging, Alzheimer's Disease (AD)
Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study
Developing efficient cognitive intervention for cognitively health older adults is a major public health goal, due to its potential for reducing age-related cognitive decline and Alzheimer's disease/dementia risk.
- Trial name
- MUST (NCT06995638)
- Testing
- Web-based Cognitive Training (with strategy), Web-based Cognitive Training (without strategy)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Active Aging Individuals Aged 60 and Over
Effects of Exergame and Gross Motor-Cognitive Training in Older Adults: An RCT
Background: Aging leads to a progressive decline in gross-motor skills and executive functions, significantly increasing fall risks.
- Trial name
- NCT07701317
- Testing
- allenamento tramite Exergame, Gross motor-cognitive training
- Where
- Italy
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Frailty
Safety, Efficacy of FFP From Healthy Donors to Ameliorate Frailty and Enhance Immune Function in Older Individuals
1. Primary Objective To determine the safety and tolerability of 12 once monthly transfusions of GMFFP (Granulocyte - Colony Stimulating Factor (G-CSF) Mobilized Fresh Frozen Plasma harvested from young, healthy donors), given to…
- Trial name
- NCT03458429
- Testing
- GMFFP
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dipnarine Maharaj
Vascular Aging
Vascular Aging and Lp299v Study in Healthy Adults
Emerging data suggest the gut microbiota regulates multiple mechanisms related to vascular aging, but no intervention targeting the gut microbiota has been tested in older adults without cardiovascular risk factors or…
- Trial name
- NCT05296395
- Testing
- Lactobacillus Plantarum 299v in fermented oat drink
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Heart Failure, Ageing
Leipzig Exercise Intervention in Chronic Heart Failure and Aging
In both ageing and heart failure progressive exercise intolerance is observed. The Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study aims to investigate how aerobic short-term training interventions…
- Trial name
- LEICA (NCT00176319)
- Testing
- Aerobic endurance exercise training (ergometer)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Alzheimer Disease, Sleep
Sleep, Rhythms and Risk of Alzheimer's Disease
Alterations in sleep and the sleep / wake cycle, which are particularly common in Alzheimer's disease patients, could represent an early biomarker for cognitive decline and onset of dementia .
- Trial name
- AMImage3 (NCT04044495)
- Testing
- Multimodal brain imaging (MRI), Actimetry, Sleep Diary
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Bordeaux
Aging, Athletic Injuries
Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability.
- Conditions
- Aging, Athletic Injuries, Physical Inactivity, Knee Injuries and Disorders
- Trial name
- NCT05344001
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Marquette University
Kidney Transplantation, Multiparametric Magnetic Resonance Imaging
Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing
Development of renal fibrosis is the irreversible culmination of various renal diseases and independently predicts adverse outcomes. Currently renal fibrosis can only be diagnosed by performing a renal biopsy.
- Conditions
- Kidney Transplantation, Multiparametric Magnetic Resonance Imaging, Living Donors, Renal Fibrosis
- Trial name
- MpRenal (NCT06210555)
- Testing
- Renal transplantation, Living kidney donation
- Where
- 2 sites in Denmark
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Patrick Schjelderup
Sarcopenia, Hypertension
Effects of Variable Load Exercise on Aging Atrophy
The primary aim of this research proposal is to examine whether this novel training program approach is capable to tackle excessive loss in muscle mass, function and contractile capacity with aging.
- Conditions
- Sarcopenia, Hypertension, Muscle Atrophy
- Trial name
- NCT03690258
- Testing
- Variable load exercise
- Where
- 2 sites in Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital of Split
Aging, Mitochondrial Function
NAD Supplementation Study
This research project aims to determine whether supplementing with a mixture of the NAD+-precursors NA, NAM, and tryptophan can stimulate skeletal muscle mitochondrial function in physically compromised, elderly humans.
- Trial name
- NADS (NCT03310034)
- Testing
- NAD-precursors, Control
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Atrial Fibrillation Recurrent, Aging
Investigating the Effects of a Museum Intervention on the Psychological and Cardiac Health of Older Adults
In a recent report, the World Organization for Health provided some evidence that artistic and cultural activities can support the health and well-being of the population.
- Trial name
- HeART-BRAIN (NCT06130358)
- Testing
- Experimental: Well-being intervention followed by classic intervention, Experimental: Classic intervention followed by well-being intervention
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louis Bherer
Postmenopausal, Female
How Seasons Affect Kidney Health in Post-Menopausal Females
The investigators are assessing how seasonal changes affect kidney function biomarkers in post-menopausal women, an understudied group.
- Trial name
- NCT06866743
- Testing
- There will be no intervention.
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Florida State University
Elderly Women
Effects of Water-based Aerobic and Combined Training in Elderly Woman
Purpose: Investigate neuromuscular, cardiorespiratory, functional capacity, quality of life and cognitive adaptations of eight weeks of water-based aerobic and combined training in elderly women previously trained for eight weeks…
- Trial name
- ACTIVE (NCT03892278)
- Testing
- Water-based aerobic training, Water-based aerobic and combined training, Control group
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Aging
Acute Effect of Exercise on Vascular Function
The study objectives are the following: 1) To examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) To examine the influence of age and gender on these responses.
- Trial name
- NCT02408614
- Testing
- Slow-paced walking, Moderate-paced walking, Interval Training
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Florida
Physical Functional Performance, Psychological Health
Interactive Exergaming With Otago Exercise Program on Mobility in Community-Dwelling Older Adults
This clinical trial aims to evaluate the effectiveness of interactive exergaming combined with Otago Exercise Program on mobility among community-dwelling older adults aged 65 and above.
- Conditions
- Physical Functional Performance, Psychological Health, Physical Fitness, Mobility Limitation
- Trial name
- GAME-OEP (NCT06814678)
- Testing
- Interactive Exergaming with Otago Exercise Program, Control Group with Usual Care
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Nerve Degeneration, Healthy Aging
Quantifying the Trainability of Peripheral Nerve Function in Young and Older Adults.
The purpose of this project is to identify the effects of hand grip resistance training on nerve speed of the hand muscles and to quantify whether age plays a role in those effects.
- Trial name
- NCT06614556
- Testing
- Resistance Training
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University