Clinical trials: Functional Aging
Rheumatoid Arthritis
STudying Ageing in Rheumatic Diseases (STAR)
The primary objective of the STAR study is to investigate how measures of disease activity and measures for cognition, physical activity and performance behave in ageing population controls and patients with rheumatoid arthritis…
- Trial name
- NCT05463666
- Testing
- Rheumatoid arthritis
- Where
- Netherlands
- Volunteers
- 840 people
- Sponsor
- Maastricht University Medical Center
Sarcopenia, Ageing Well
Effects of Microcurrent Treatment With and Without Resistance Exercises
Aim: to analyse the effects of microcurrent treatment alone, and combined with a resistance exercise programme, on muscle strength, body composition and physical functional capacity in middle-aged adults.
- Trial name
- NCT05567237
- Testing
- Microcurrent treatment with resistance exercise programme, Resistance exercise programme, Microcurrent treatment
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Aging, Disorder, Neurologic
Music, Virtual Reality for Patients in IUGM
Promoting good care, well-being and quality of life for geriatric patients is a long-standing initiative in Quebec, and one in which the Institut Universitaire de Gériatrie de Montréal (IUGM) has always been a leader.
- Trial name
- NCT06296199
- Testing
- VR, Music only
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal
Healthy
The Effect of Probiotic Supplementation on Cognitive and Emotional Functions in Healthy Elderly Subjects
This study evaluates the cognitive and emotional effects of probiotics in healthy elderly patients.
- Trial name
- NCT04828421
- Testing
- Lactobacillus rhamnosus and Bifidobacterium lactis
- Where
- 3 sites in Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Aging
Effects of Slow-speed Traditional Resistance Training, High-speed Resistance Training and Multicomponent Training With Variable Resistances on Molecular, Body Composition, Neuromuscular, Physical Function and Quality of Life Variables in Older Adults.
Human aging is characterized by a progressive deterioration of multiple physiologic systems, with marked decreases in skeletal muscle mass, muscle strength, physical function and quality of life beginning in the sixth decade in…
- Trial name
- NCT03455179
- Testing
- Slow-speed traditional resistance training, High-speed resistance training, Multicomponent training
- Where
- 3 sites in Spain
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Healthy
Effects of Vitamin D3 Supplementation on Cognitive Function in Community Dwelling Older Adults
Ireland is predicted to have the highest older adult population growth of any European Union country. A substantial economic and social challenge of this projected growth is the increased incidence of cognitive impairment and the…
- Trial name
- NCT02804841
- Testing
- Cholecalciferol -Vitamin D3
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Physical Activity, Biological Aging
Exercise Referral Schemes Enhanced by Self-Management Strategies to Battle Sedentary Behaviour
The increase of the elderly population leads to increased prevalence of frailty, risk for poor health outcomes, and related health and social care costs.
- Conditions
- Physical Activity, Biological Aging, Frail Older Adults, Controlled Clinical Trials, Randomized
- Trial name
- SitLESS (NCT02629666)
- Testing
- ERS and/or Self-management Strategies
- Where
- Spain
- Volunteers
- 1,360 people, healthy volunteers welcome
- Sponsor
- University Ramon Llull
Aging, Disease
Interval Training, Inflammation and Immune Function
PURPOSE: The purpose of this study is to investigate whether High Intensity Interval Training (HIIT)can improve the health and wellbeing of pre-diabetic elderly adults.
- Trial name
- NCT02441205
- Testing
- High Intensity Interval training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Vulvar Atrophy, Vulvovaginal Signs and Symptoms
Retrospective Cohort Study of Symptoms and Quality of Life in Women With Genitourinary Syndrome of Menopause.
The goal of this clinical trial is to retrospectively identify the most prevalent symptoms of genitourinary syndrome of menopause (GSM) among postmenopausal women and to evaluate their impact on quality of life.
- Conditions
- Vulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause (GSM), Quality of Life
- Trial name
- NCT07737782
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Mucosa Innovations, S.L.
Aging
Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly
The ability to mount an effective immune response declines with age, leaving the elderly increasingly susceptible to infectious diseases and cancer.
- Trial name
- NCT02874924
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Aging, Mobility Limitations
Life 2: Improving Fitness and Function in Elders
The purpose of this study is to determine whether a 12-month physical activity counseling program, compared to usual care, improves physical performance in a sample of older veterans.
- Trial name
- Project LIFE (NCT00435188)
- Testing
- Multi-component physical activity counseling program
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Cognition, Diabetes Mellitus, Type 2
Adaptive Cognitive Training on Cognitive Function in Elderly Diabetes Patients in the Community
Objective A growing body of evidence supports diabetes as a risk factor for cognitive decline. Diabetes is significantly associated with accelerated cognitive decline, poorer cognitive function, and mild cognitive impairment and…
- Conditions
- Cognition, Diabetes Mellitus, Type 2, Aging
- Trial name
- NCT06524388
- Testing
- adaptive cognitive training
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fanfan Zheng
Aging and Exercise Impacts on Glymphatic Function
Aging and Exercise Impacts on Glymphatic Function
This is a prospective, interventional, non-blinded, single center research project that will recruit cognitively unimpaired subjects in the 25-55 year old and 55-75 year old range.
- Trial name
- NCT07775196
- Testing
- Acute Aerobic exercise
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Aging
Metabolic and Functional Consequences of Aging in Health and Disease
Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be…
- Trial name
- NCT05240885
- Testing
- Stable tracer infusion in a postabsorptive state
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Obesity, Weight Loss
Utilizing Protein During Weight Loss to Impact Physical Function and Bone
This study is an ancillary study to the Utilizing Protein During Weight Loss to Impact Physical Function (UPLIFT) trial (NCT03074643) to evaluate the effects of diet composition (i.e., amount of protein and carbohydrate) during a…
- Conditions
- Obesity, Weight Loss, Diet Modification, Aging
- Trial name
- UPLIFT-Bone (NCT03819478)
- Testing
- Weight loss intervention months 0-6, Exercise intervention months 0-6, NutraBio™ CarboMax Supplement
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Wake Forest University Health Sciences
Aging
Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex
Nicotine enhances auditory-cognitive function because it mimics the brain's system for "paying attention" to important sounds amid distractions (for example, understanding speech in a noisy environment).
- Trial name
- NCT05018117
- Testing
- Nicotine gum
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Aging
The Effect of Bikram Yoga on Arterial Stiffness and Endothelial Function in Middle-Aged Adults
Arterial stiffening and endothelial dysfunction are correlates of advancing age contributing to the decline in cardioprotection with age.
- Trial name
- NCT02488148
- Testing
- Hot yoga, Non-heated yoga
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Central Nervous System Disease, Cerebrovascular Accident
Brain Processing of Language Meanings
This research trial will study discourse processing-that is, how the brain processes the meaning of language. It will examine, for example, how words and sentences are interpreted in cases where more than one meaning is possible.
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury
- Trial name
- NCT00005004
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Microbiome, Immune Function
The RAMP Study - Rejuvenation of the Aging Microbiota With Prebiotics
An individual's immune and metabolic status is coupled to consumed carbohydrates. Complex carbohydrates that are not digested by human enzymes may influence host biology by impacting microbiota composition and function, or act in…
- Conditions
- Microbiome, Immune Function, Inflammation
- Trial name
- RAMP (NCT03690999)
- Testing
- Prebiotic supplement
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Stanford University