Clinical trials: Functional Aging
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline
Glucose Variability and Cognition in Prediabetes
This study examines the association of variability in glucose values over a 10-day period with cognitive function and AD risk markers among individuals with prediabetes, aged 50 or older.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, PreDiabetes, Aging
- Trial name
- NCT04201600
- Testing
- Continuous Glucose Monitoring System (CGMS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Sarcopenia
Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults
The investigators recently published significant associations between circulating gut bacteria-related metabolites with lean and skeletal muscle mass and with measures of physical function in older adults, evidence that suggests…
- Trial name
- NCT02811445
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tufts University
Obesity
Females, Aging, Metabolism, and Exercise
This study is designed to determine whether a reduction in hormones (such as occurs during menopause) causes a decrease in calories burned during physical activity.
- Trial name
- FAME (NCT01712230)
- Testing
- GnRH agonist, Supervised cardiovascular exercise
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Aging, Endothelial Dysfunction
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic…
- Conditions
- Aging, Endothelial Dysfunction, Cardiovascular Function, Arterial Stiffness
- Trial name
- NCT05872139
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ball State University
Aging Disorder, Obesity
Effects of Multicomponent Training on Inflammation Parameters and Muscle Quality in Elderly Obese Woman
Population aging worldwide has increased substantially in recent years. In order to prevent disabling diseases and improve the quality of life, it is necessary to understand the conditions related to the health of this specific…
- Conditions
- Aging Disorder, Obesity, Inflammation
- Trial name
- NCT05552677
- Testing
- Multicomponent Training
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo
Overweight (BMI > 25), Obesity & Overweight
WB-EMS Combined With Nutritional Guidance for a High-Protein Diet on Body Composition, Muscle Function, Psychological and Functional Outcomes in Older Adults With Excess Adiposity
This is a 16-week randomized controlled trial (RCT) with outcome assessor blinding. The objective is to investigate the effects of resistance training (RT) combined with whole-body neuromuscular electrical stimulation (WB-NMES)…
- Conditions
- Overweight (BMI > 25), Obesity & Overweight, Aging
- Trial name
- WB-EMS (NCT07859072)
- Testing
- Whole-Body Neuromuscular Electrical Stimulation (WB-NMES), Conventional Resistance Training, High-Protein Nutritional Guidance
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Universidade Cesumar (UNICESUMAR)
Eye Fatigue
Eye Care Benefits of Anti-Aging Compound Capsules in Healthy Adults
This study aims to evaluate the eye care benefits of anti-aging compound capsules in healthy adults. Participants will consume anti-aging compound capsules containing botanical extracts, omega-3 fatty acids, vitamins, minerals…
- Trial name
- Eye Care (NCT07657936)
- Testing
- Anti-Aging Compound Capsules
- Where
- Taiwan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Aging
Effect of Aerobic Interval Training on Cardiovascular Function in Aging
Study objectives: 1. To compare cardiovascular function in older compared to young healthy adults. 2. To compare the effect of 8 weeks of aerobic interval training vs.
- Trial name
- NCT01883271
- Testing
- High intensity aerobic interval training, Continuous moderate intensity exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Frail Elderly, Aging
Targeting Aging With a Ketone Ester for Function in Frailty
This study aims to find out if a food supplement that contains a naturally occurring substance, ketones, can help to improve strength and general wellness in adults at, or over the age of 65 years who are experiencing a slight…
- Conditions
- Frail Elderly, Aging, Immune Function, Muscle Function
- Trial name
- TAKEOFF (NCT06645847)
- Testing
- Ketone ester
- Where
- 3 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Buck Institute for Research on Aging
Parkinson Disease
Human Aging and in Vivo Noradrenergic System
The main goal of this research proposal is to provide, for the first time in humans, a wider understanding of the role of the noradrenergic system both in health and illness (Parkinson's disease) through the use of a newly…
- Trial name
- NA_PET_MRI (NCT03942289)
- Testing
- The role of the noradrenergic system across the life span (Healthy Subjects), The role of the noradrenergic system across the life span (Parkinson's Disease Subjects)
- Where
- France
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Immune Response
The Immune Function Intervention Trial
The purpose of the study is to examine whether cardiovascular exercise training improves immune responses to vaccination in previously sedentary older adults.
- Trial name
- ImFIT (NCT00548990)
- Testing
- cardiovascular exercise training, flexibility/balance control
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
HIV Infections, Cardiovascular Diseases
Implementation and Effectiveness of Physical Activity to Prevent Disability in HIV-infected Adults Older Than 50 From Côte d'Ivoire
The overall objective of this research is to provide evidence on the effectiveness and implementation of two strategies deliver a structured programme of physical activity (PA) people living with HIV older than 50 years from…
- Conditions
- HIV Infections, Cardiovascular Diseases, Insulin Resistance Syndrome X
- Trial name
- VIRAGE+ (NCT06139497)
- Testing
- Physical activity programme, Home-based physical activity
- Where
- 2 sites in Côte d’Ivoire
- Volunteers
- 180 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Cognitive Aging, Functional Magnetic Resonance Imaging
Strategic Training to Optimize Neurocognitive Functions in Older Adults
The goal of the present randomized control trial is to evaluate the efficacy of a novel cognitive training approach using simulated games, where older adults will learn to flexibly deploy attentional control during working…
- Trial name
- ViCTOR (NCT03988829)
- Testing
- Low-C, High-C, High-C+
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Aging Disorder
EFFECTS OF RESISTANCE TRAINING IN ELDERLY
This comes from a non-randomized clinical trial, which aims to check on elderly women the effects of a program of resistance training (TR) in physical performance, in respiratory functional capacity, on health and quality of life.
- Trial name
- NCT03320005
- Testing
- Resistance training group
- Volunteers
- 25 people
- Sponsor
- Daysi Tobelem
Kidney Diseases
Comparative Renal Function of Young (18-45 Years) and Ageing (55 Years and Above) Kidney Donors
It is our purpose in this study to compare the kidney structure and function of older patients to that of young patients before and after removal of a single kidney for transplant donation and to examine the remaining kidney's…
- Trial name
- NCT00846729
- Testing
- CT angiogram of the remaining kidney., Kidney Function study using Iothalamate & PAH as clearance markers
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
Frailty, Aging
MItochondrial Intervention for Resilience in Older Adults With Coenzyme Q10
This randomized, double-blind, placebo-controlled clinical trial will investigate whether 10 weeks of CoQ10 supplementation can improve biological resilience and functional health in community-dwelling adults aged 65 years or…
- Conditions
- Frailty, Aging, Mitochondria Health, Skin Aging
- Trial name
- MIRO-Q (NCT07772336)
- Testing
- Q10Vital® (CoQ10, ubiquinone)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Infertility, Female, Infertility Unexplained
Effects of Age and Infertility on Ovarian Granulosa Cell Function
Infertility is a life changing disorder, affecting 1 in 7 couples within the UK. Treatment options pose a significant cost burden to both the NHS and patient when NHS-funded treatment options are exhausted.
- Conditions
- Infertility, Female, Infertility Unexplained, Infertility of Tubal Origin, Infertility
- Trial name
- NCT04945265
- Volunteers
- 500 people
- Sponsor
- King's College London
Ageing
Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly
The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly.
- Trial name
- CardiacAging (NCT02791139)
- Testing
- Cardiovascular Magnetic Resonance Imaging (MRI), Echocardiography, Tonometry
- Where
- Singapore
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Sleep, Anxiety
Xbox Kinect, Sleep Quality, Anxiety and Functional Capacity in Older Adults
The present study aims to examine the effects of Xbox Kinect exercise training program on the sleep quality, anxiety and functional capacity in older adults. Older adults were randomized into two groups.
- Conditions
- Sleep, Anxiety, Aging, Exercise
- Trial name
- NCT04692272
- Testing
- Exercise in the XBOX kinect
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Aging, Nursing Homes
Effect of Sunlight Exposure and Outdoor Activities on Depression, Cognition and Quality of Life in the Elderly
Background: The transition to long-term care facility can be a stressful and emotional event for the elderly. The evidences showed that the prevalence of depression and the cognition impairment were higher in the…
- Conditions
- Aging, Nursing Homes, Depression in Old Age, Cognitive Impairment
- Trial name
- NCT03304301
- Testing
- sunlight exposure
- Where
- Taiwan
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Chiayi Christian Hospital