Clinical trials: Functional Aging
Sarcopenia, Muscular Atrophy
Exercise and Nutrition Interventions in Age-related Sarcopenia
This project will investigate the synergistic effects of Aerobic and Resistance type Exercise, in combination with Protein Supplementation, on; Body Composition, Musculoskeletal Functioning, Nutritional Status and Quality of Life…
- Trial name
- NCT02912130
- Testing
- Protein Supplementation, Aerobic Exercise, Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Liverpool Hope University
Accidental Falls
Intervention to Enhance Lateral Balance Function and Prevent Falls in Aging
Falls and their consequences are among the major problems in the medical care of older individuals. The long-term goal of this research is to establish the efficacy of a scientifically grounded and mechanism-based therapeutic…
- Trial name
- LIFT (NCT01370174)
- Testing
- Physical Training Interventions
- Where
- 2 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Healthy Aging, Mobility Limitation
Power Centering for Seniors
Walking difficulties, mobility decline and falls are prevalent among older adults. The incidence of each of these increases with age and the presence of each can negatively affect the quality of life in older adults.
- Conditions
- Healthy Aging, Mobility Limitation, Walking, Difficulty
- Trial name
- PCS (NCT04861831)
- Testing
- Power Centering for Seniors intervention
- Where
- Switzerland
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Department of Geriatric Medicine FELIX PLATTER
Improving Cardiometabolic Outcomes in Older Adults
Aging Program Project Grant 6
This study aims to enhance circadian signals to improve cardiometabolic functions in older adults though meal timing interventions and melatonin supplements.
- Trial name
- PPG6 (NCT03490825)
- Testing
- Melatonin 1 mg, Meal timing, Non-Meal timing
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Aging
Effects of Home-Based Ankle Training Program on The Muscle Strength, Balance and Gait Function in the Elderly
The occurrence of frequent falls influences the independence of the elderly's physical functions, and the factors related to falls include: weakness in the lower limbs, age, past injury experiences and so forth.
- Trial name
- NCT05790369
- Testing
- Resistance training (New ankle machine training), Resistance training (Elastic band training )
- Where
- Taiwan
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Aging
Effect of Encapsulated Vs Free Probiotic on Brain Function
Aging is associated with changes in a wide variety of brain networks, including the default mode, saliency attention, and visual networks.
- Trial name
- NCT05801042
- Testing
- Maltodextrin, Encapsulated Lactocaseibacillus rhamnosus, Non-encapsulated Lactocaseibacillus rhamnosus
- Where
- Sweden
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Robert Brummer
Healthy, Stroke
Influence of Brain Oscillation-Dependent TMS on Motor Function
Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands.
- Conditions
- Healthy, Stroke, Normal Physiology, Aging
- Trial name
- NCT03288220
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mild Cognitive Impairment, MCI
Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease
A double-blind, placebo-controlled study that aims to investigate the effect of 2-week and 12-week administration of USP methylene blue (MB) on cerebral blood flow, functional connectivity, memory and attention cognitive…
- Conditions
- Mild Cognitive Impairment, MCI, Aging, Alzheimer's Disease
- Trial name
- MB2 (NCT02380573)
- Testing
- Methylene Blue, FD&C Blue # 2, Phenazopyridine hydrochloride
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Inflammation, Immune System
Design and Development of a Functional Plant-based Beverage to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
In 2018, for the first time, the number of people aged 65 and over exceeded the number of children under the age of 5. A rise in ageing societies is coming, and new efforts are needed to ensure that this increase in life…
- Trial name
- Immugold (NCT07409480)
- Testing
- Functional plant-based beverage, Control Beverage
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Mild Cognitive Impairment
Spatial Memory Training and Cognitive Function
Mild cognitive impairment (MCI) is often considered a transitional stage between normal aging and dementia, particularly Alzheimer's disease (AD).
- Trial name
- NCT07002996
- Testing
- SMIP, No intervention
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Douglas Mental Health University Institute
Healthy
Myocardial Fibrosis, Function and Aging
In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age.
- Trial name
- MARVEL (NCT03064503)
- Testing
- Blood sampling, MRI, Skin auto-fluorescence
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Aging
Chronic Passive Heating in Healthy Older Adults
Aging is associated with a decline in cardiovascular health, cognitive function and losses in muscle strength, with half or more of those over age 65 suffering from two or more comorbidities (e.g., heart disease, type 2…
- Trial name
- NCT05618197
- Testing
- Passive heating
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Aging, Physical Functional Performance
Physical Function From the Perspective of Active Ageing
The aim of this study is to evaluate physical function from the perspective of active aging as well as to determine the relationship between physical activity and physical performance in the context of active aging.
- Conditions
- Aging, Physical Functional Performance, Physical Activity, Active Ageing
- Trial name
- NCT06733818
- Testing
- Functional assessment of physical performance
- Where
- Turkey (Türkiye)
- Volunteers
- 455 people
- Sponsor
- Suleyman Demirel University
Healthy Ageing
Effect of Polyphenol-rich Cocoa Products on Cognitive Function
This project aims to investigate whether consumption of cocoa polyphenols has an impact on cognitive function in individuals aged 50 to 60 years of age and if such an improvement is a result of an improvement in risk factors…
- Trial name
- NCT02996578
- Testing
- polyphenol rich chocolate bar, polyphenol rich cocoa powder, low polyphenol content chocolate bar
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Ageing, Blood Flow Restriction
Comparing Vascular Responses to Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults
Aging leads to declines in functional capacity and effort tolerance. Muscle strength remains stable from ages 25 to 50 but declines significantly after age 60, affecting activities like stair climbing and walking, reducing…
- Trial name
- HOLD TIGHT (NCT06596304)
- Testing
- Low intensity-resistance training with lower limb blood flow restriction, High Intensity Resistance Training
- Where
- 2 sites in Portugal
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Cognitive Decline, Aging
Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning, Immunometabolic- and Intestinal Markers in Ageing
COMBI is a multi-center, randomized controlled trial among 70 older adults at risk of cognitive decline. The main goal is to investigate the effect of a 6-week colon-delivered multivitamin supplementation on the gut-brain axis in…
- Trial name
- COMBI (NCT05675007)
- Testing
- Colon-delivered multivitamin supplement
- Where
- 2 sites in Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Donders Centre for Cognitive Neuroimaging
Aging, Exercise Movement Techniques
Effect of Different Volumes of Training of Pilates Exercises on Elderly
It will be an experimental study conducted with elderly of both sexes, these will be divided randomly into three groups and the intervention will happen twice a week, for 60 minutes, for 12 weeks.
- Trial name
- NCT03791502
- Testing
- Pilates Method Exercises
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Aging, Menopause
MitoQ and Exercise Effects on Vascular Health
An impairment in vascular function can lead to the development of age-associated cardiovascular disease (CVD), the leading cause of death in postmenopausal women.
- Trial name
- MITO-STEP (NCT05686967)
- Testing
- MitoQ, Aerobic exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction
Cardiac Energetics and Function in Normal Human Ageing
Normal aging is characterized by altered cardiovascular function. Our preliminary data with MR imaging and spectroscopy in normal subjects without cardiovascular disease or hypertension show that age-related cardiac dysfunction…
- Conditions
- Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction, Ageing
- Trial name
- NCT01504828
- Testing
- Ramipril
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Elderly, Older Adults, Aging Brain
Effects of Physical Exercise and Cognitive Training on Quality of Life in Older Women
Ageing exposes people to a progressive loss of cognitive and functional abilities, especially in women. The aim of the study is to investigate the effectiveness of different types of intervention, based on physical exercise…
- Trial name
- INCOGNITO (NCT07244562)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION, Exercise plus cognitive training, Exercise plus cognitive stimulus at home
- Where
- Italy
- Volunteers
- 124 people
- Sponsor
- University Hospital of Ferrara