Clinical trials: Functional Aging
Cognitive Impairment
Impact of Resistance Training Volume on Cognitive Function and Physical Performance in Cognitively Impaired Individuals
This research project aims to analyze the effects of different resistance training volumes on cognitive function, oxidative stress, inflammatory markers, lipid profile, glycemic status, muscle damage, hemodynamic response, and…
- Trial name
- TRAIN4BRAIN (NCT06528951)
- Testing
- Control Phase ( 6Weeks), 15% increase in resistance training volume (10 Weeks), 30% increase in resistance training volume (10 Weeks)
- Where
- Portugal
- Volunteers
- 69 people
- Sponsor
- University of Beira Interior
Aging, Erythrocyte Glutathione Deficiency
Energetics and Function in Older Humans
The investigators have previously reported that older patients with HIV are deficient in glutathione (GSH) due to decreased availability of cysteine and glycine, and that oral supplementation with cysteine (as n-acetylcysteine)…
- Conditions
- Aging, Erythrocyte Glutathione Deficiency, Muscle Weakness
- Trial name
- NCT02348762
- Testing
- Cysteine (as n-acetylcysteine) and Glycine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Ageing
Nitrite Supplementation for Improving Physiological Function in Older Adults
Nitric oxide (NO) is an essential molecule in the body that decreases with aging and causes reductions in vascular, movement ("motor") and cognitive functions.
- Trial name
- NITRITE (NCT02393742)
- Testing
- Sodium nitrite
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Edentulism, Biological Aging
Biological Aging Following Full-Arch Implant-Supported Fixed Rehabilitation in Edentulous Patients
This study aims to investigate the association between full-arch implant-supported fixed dental rehabilitation and changes in biological aging among adults with complete tooth loss (edentulism).
- Trial name
- NCT07890753
- Testing
- Full-Arch Implant-Supported Fixed Dental Rehabilitation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Junyu Shi
Healthy Ageing, Cognitive Decline
Fitness, Ageing, and Bilingualism (FAB): The Benefits of Regular Exercise and Bilingualism for Language Abilities in Healthy Ageing.
This project investigates the relative benefits of regular physical activity and bilingualism for ameliorating cognitive decline in healthy ageing, with a particular focus on language function.
- Conditions
- Healthy Ageing, Cognitive Decline, Cardiorespiratory Fitness
- Trial name
- FAB (NCT07443189)
- Testing
- Home-Based HIIT
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Agder
Aging, Sarcopenia
Impact of Fish Oil Dose on Tissue Content and Function
In this 5-month study, we will track the incorporation and washout of n-3 PUFA into different tissues following two different dosing strategies in healthy young and older volunteers. All groups will be followed for washout.
- Conditions
- Aging, Sarcopenia, Muscle Atrophy
- Trial name
- NCT04772040
- Testing
- Fish oil supplementation
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Stirling
Aging, Healthy
Study of Healthy Aging and Physical Function With Elamipretide
This study will utilize a daily dose of elamipetide for 4 weeks and will screen a sufficient number of subjects for 30 subjects to enroll in the study.
- Trial name
- SHAPE (NCT07275424)
- Testing
- Elamipretide will be supplied as a sterile 5.0 mL single-patient, multi-dose glass vial containing 3.75 mL of elamipretide solution (elamipretide [80 mg/mL], phosphate buffer, and benzyl alcohol)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- David Marcinek
Vitamin D, Physical Function
Vitamin D and Physical Function in Older Adults
Projections from NHANES III indicate that approximately 12,000,000 U.S. adults ≥ 60 years of age have vitamin D insufficiency (serum 25(OH)D < 50 nmol/L).
- Trial name
- NCT00710957
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Vascular Aging
Vascular Aging and Lp299v Study in Healthy Adults
Emerging data suggest the gut microbiota regulates multiple mechanisms related to vascular aging, but no intervention targeting the gut microbiota has been tested in older adults without cardiovascular risk factors or…
- Trial name
- NCT05296395
- Testing
- Lactobacillus Plantarum 299v in fermented oat drink
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Alzheimer's Disease
Pathological and Non-pathological Aging, Physical Activity, Genotype and Cognition
Alzheimer's disease (AD) is an irreversible, progressive brain disease. It is the most common form of dementia and the major cause of functional dependence in the elderly.
- Trial name
- VIAGECO (NCT02520232)
- Testing
- Combination of aerobic and strength exercises, Stretching and balance exercise program
- Where
- 2 sites in France
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline
Glucose Variability and Cognition in Prediabetes
This study examines the association of variability in glucose values over a 10-day period with cognitive function and AD risk markers among individuals with prediabetes, aged 50 or older.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, PreDiabetes, Aging
- Trial name
- NCT04201600
- Testing
- Continuous Glucose Monitoring System (CGMS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Transcranial Direct Current Stimulation (tDCS), Ageing
Investigating the Effectiveness of a 2-week Novel Non-invasive Brain Stimulation Technique on Cognitive Outcomes in Healthy Adults
The goal of this randomised controlled trial is to investigate the effects of a 2-week high-frequency transcranial pulsed current stimulation (tPCS) on cognitive outcomes in older and healthy adults.
- Conditions
- Transcranial Direct Current Stimulation (tDCS), Ageing, Executive Functioning, Transcranial Electric Stimulation
- Trial name
- NCT06991764
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Mild Cognitive Impairment
Investigating Mild Cognitive Impairment in Patients And Controls With TD-fNIRS
The goal of the proposed observational, multi-site study is to use fNIRS neurophysiological data recorded during a battery of tasks to detect MCI within a cohort consisting of patients and age-matched healthy controls.
- Trial name
- IMPACT (NCT05996575)
- Testing
- fNIRS measurement
- Where
- 6 sites in United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Kernel
Frailty
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems.
- Trial name
- HIIT@Home (NCT05625204)
- Testing
- Center based attention (stretching only) control, Center based HIIT, Home based HIIT
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment
The Effects of a Carotenoid Intervention on Cognitive Function
Past research suggests that retinal lutein levels are related to cognitive function as measured via behavioral tests. The goal of the present study is to investigate the relationship between lutein and cognitive function in a…
- Trial name
- NCT02023645
- Testing
- active supplement
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Georgia
VITAMIN D DEFICIENCY
An Evaluation of the Effect of Vitamin D Supplementation on the Cognitive Function of Older Subjects With Low Levels of This Vitamin
Background: Ageing is associated with an increased risk of cognitive decline and depression. Vitamin D plays an important role in many of the symptoms and conditions related to advanced age, including impaired balance, falls and…
- Trial name
- NCT02381600
- Testing
- Vitamin D
- Where
- Israel
- Volunteers
- 1 people
- Sponsor
- Meir Medical Center
Systemic Inflammation, Aging
Papaya Study ID:20140628
The purpose of this research study is to explore the effects of fermented papaya preparation (FPP) on whole body inflammation, physical function, fatigue, and health-related quality of life.
- Trial name
- NCT02051634
- Testing
- Fermented Papaya Preparation (FPP), Sugar Pill
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sarcopenia
Exercise and Nutrition for Healthy AgeiNg
The aim of this randomized placebo-controlled 5-arm clinical trial is to evaluate the effect of combined anabolic interventions compared to single or placebo interventions on physical performance in community-dwelling…
- Trial name
- ENHANce (NCT03649698)
- Testing
- Home-based training program, High-quality protein supplement, Omega-3 fatty acid
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Aging
The Role of Sirolimus in Preventing Functional Decline in Older Adults
Aging is associated with progressive impairment of tissue and organ function, resulting in increased susceptibility to chronic disease, frailty and disability.
- Trial name
- NCT05237687
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Irina Timofte
Aging
Aquatic Exercises Combined With Cognitive Tasks for Older Adults
The aquatic environment has characteristics that favor the adherence of older adults to exercise programs, and studies have shown that programs in this setting are effective in enhancing various aspects of physical fitness as…
- Trial name
- WaterCog (NCT07156708)
- Testing
- Aquatic aerobic exercise program, Cognitive tasks
- Where
- Brazil
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas