Clinical trials: Functional Aging
Aging, Sarcopenia
Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals
Nitrate is a naturally-occurring substance found in foods, especially green leafy vegetables and beets. Increasing nitrate intake (by drinking beetroot juice (BRJ) has been shown to improve muscle function young and middle-aged…
- Trial name
- NCT03595774
- Testing
- Beet root juice
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Indiana University
Osteosarcopenia
An Assessment of Risk Factors for Osteosarcopenia in Older Adults - the Role of Prevention, Lifestyle, Physical Activity and Education.
The aim of the study is to assess the risk factors for osteosarcopenia in older adults, taking into account physical activity, healthy eating habits and education.
- Trial name
- NCT07519720
- Testing
- As part of the study, participants will undergo body composition analysis, bone density testing, and tests of physical fitness and handgrip strength in both the older and younger age groups.
- Where
- Poland
- Volunteers
- 250 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Oral Health of Older Men, Dietary Assessment of Older Men
Composition of Functional Tooth Units and Nutrient Intake in Older Men
Various definitions of poor dentition in older adults has been linked with inadequate intake of nutrients and poor diet quality.
- Trial name
- CHAMP (NCT03295435)
- Testing
- Composition of functional tooth units
- Where
- Australia
- Volunteers
- 781 people
- Sponsor
- University of Sydney
Biomarkers of B-vitamin Status and Gut Microbiome Composition
Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood)
Ageing is associated with changes in gut microbiota composition, increased inflammation, and a greater risk of poor mental health outcomes.
- Trial name
- NCT07592975
- Testing
- Inulin and B-vitamins, Inulin
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Coenzyme Q10, Oxidative Stress
Bioavailability and Impact of Coenzyme Q10 in Stressing Exercise in Senescence Athletes
It is proposed to establish a group of subjects composed of 10 healthy individuals of> 50 years and <65, physically active, without metabolic or inflammatory pathology.
- Conditions
- Coenzyme Q10, Oxidative Stress, Aging
- Trial name
- CoQ10Sport (NCT03893864)
- Testing
- Administration of a product with Fitosomed Ubiquinone, Coenzyme Q10 level in muscle biopsies, Coenzyme Q10 level in plasma, blood cells, urine cells
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre d'Alt Rendiment
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in older versus younger transgender men (people who were assigned female at birth but whose gender identity is male).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04237467
- Testing
- No intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Deglutition Disorders
Design and Development of a Functional Plant-based Beverage Formulated According to the Main Nutritional Guides for Early Elderly Requirements to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
Populations around the world are aging and this demographic transition will impact almost every aspect of society. Furthermore, the COVID-19 pandemic has highlighted the seriousness of gaps in policies, systems and services.
- Trial name
- IMMUGOLD (NCT06445309)
- Testing
- Sensory test of functional plant-based drink
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Sarcopenia, Ageing Well
Effects of Microcurrent Treatment With and Without Resistance Exercises
Aim: to analyse the effects of microcurrent treatment alone, and combined with a resistance exercise programme, on muscle strength, body composition and physical functional capacity in middle-aged adults.
- Trial name
- NCT05567237
- Testing
- Microcurrent treatment with resistance exercise programme, Resistance exercise programme, Microcurrent treatment
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Mild Cognitive Impairment, Alzheimer Dementia
Exercise, Brain, Cognition, OMICs, Molecular Markers and Functionality in People at Risk of Mild Cognitive Impairment
This project aims to examine the effect of a 5-month period supervised exercise intervention on brain, cognition, OMICs, Molecular Markers and functional status in older people at risk of mild cognitive impairment.
- Trial name
- NCT03923712
- Testing
- Supervised Exercise Programme
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- University of Cadiz
Eccentric Exercise, Home-based Training
Effects of Eccentric Training at Long Muscle Length on Functional Capacities of Elderly Adults
As aging leads to a decline in muscle function and overall physical performance, interventions targeting muscle strength and neuromechanical properties are critical for maintaining functional independence in older adults.
- Conditions
- Eccentric Exercise, Home-based Training, Elderly Adults
- Trial name
- EMULE (NCT06953258)
- Testing
- Home-based eccentric training at long muscle length, Conventional home-based training
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Robin Souron
Aging, Muscle Strength
Effect of HMB Supplementation and Vivifrail Exercise on Body Composition, Handgrip Strength and Physical Performance in Women Over 60 Years of Age
The goal of this clinical trial is to learn whether taking a daily supplement of β-hydroxy-β-methylbutyrate (HMB) while following a structured exercise program improves body composition, muscle strength and physical performance…
- Conditions
- Aging, Muscle Strength, Physical Functional Performance, Body Composition
- Trial name
- NCT07905755
- Testing
- Calcium β-hydroxy-β-methylbutyrate (HMB-Ca), Vivifrail multicomponent exercise program
- Where
- Mexico
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad Autónoma del Estado de Hidalgo
Cognitive Deterioration, Disorder of Aging
Exercise, Age-Related Memory Decline, And Hippocampal Function
The purpose of this study is to test the hypothesis that aerobic exercise leads increased cerebral blood volume in the dentate gyrus of the hippocampus in a sample of young and older adults.
- Trial name
- NCT01329653
- Testing
- aerobic training, Wait list
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Brain Aging
AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults
The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia.
- Trial name
- AvoCog (NCT06137339)
- Testing
- Avocado Group
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Accidental Falls
Influence of Cognition and Gait on Falls
The study analyses if cognition and gait speed can predict falls in a community-dwelling people and ambulant long term care residents
- Trial name
- ICGF (NCT02700672)
- Testing
- Observational study
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Healthy
Myocardial Fibrosis, Function and Aging
In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age.
- Trial name
- MARVEL (NCT03064503)
- Testing
- Blood sampling, MRI, Skin auto-fluorescence
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Aging
Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]
The ability to mount an effective immune response declines with age, leaving the elderly increasingly susceptible to infectious diseases and cancer.
- Trial name
- mTOR (NCT04742777)
- Testing
- rapamycin
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Aging
Enhancing Function in Later Life: Exercise and Functional Network Connectivity
Physiological and neurocognitive changes experienced as a result of increasing age may influence socioemotional functioning and economic behaviors, yet, the mechanisms through which these changes occur are not well understood.
- Trial name
- FORCE (NCT02068612)
- Testing
- Moderate Intensity Continuous Training+Interval Training, Low Intensity Continuous Training
- Where
- United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Mobility Limitations, Aging
A Comparison of Weighted Vest Exercise and Strength Training
The purpose of this study is to evaluate two types of exercise therapy designed to improve muscle power and mobility: weighted vest exercise vs. progressive resistance training.
- Trial name
- NCT00158119
- Testing
- InVEST (Increased Velocity Exercise Specific to Task)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute on Aging (NIA)
Aging
The Effect of Long Duration Exercise on the Diastolic Function of the Heart
The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for 2 years in sedentary middle aged men and women (ages 45-64) will improve cardiac and vascular compliance to a degree equivalent to…
- Trial name
- PEP (NCT02039154)
- Testing
- Aerobic and strength training group, Balance and flexibility group
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Frailty, Quality of Life
Indonesia Frailty, Aging, and Longitudinal Study
Frailty is a dynamic process from fit (robust) and pre-frail elderly. There is no previous study that determine the risk factors from fit to pre-frailty and pre-frailty to frailty in Indonesian elderly.
- Trial name
- INA-FRAGILE (NCT02345083)
- Where
- Indonesia
- Volunteers
- 300 people
- Sponsor
- Universitas Indonesia