Clinical trials: Functional Cardiac Disorder
Beta Thalassemia
Effects of Spirulina on Cardiac Functions in Children With Beta Thalassemia Major
The aim of this study is to evaluate the cardioprotective effect of spirulina in children with beta thalassemia.
- Trial name
- NCT02597595
- Testing
- spirulina
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Acute Kidney Injury
The Effects of Statin on Postoperative Renal Function in Valvular Heart Surgery: a Randomized, Placebo-controlled Study
The aim of this study is to examine the association between preoperative statin treatment and the incidence of postoperative acute kidney injury(AKI) in patients undergoing valvular heart surgery.
- Trial name
- NCT01909739
- Testing
- atrovastatin
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Congestive Heart Failure, Mechanical Ventilation
Nesiritide for Ventilated Congestive Heart Failure
The congestive heart failure is a common disease among patients who receive cardiac surgery and may lead to prolonged ventilation support. Nesiritide was a potential therapy for congestive heart failure.
- Conditions
- Congestive Heart Failure, Mechanical Ventilation, Using Nesiritide, Venous Return
- Trial name
- HENCHF (NCT04455477)
- Testing
- Nesiritide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease, Postoperative Pulmonary Complications
Flow-Controlled vs. Pressure-Controlled Ventilation in CABG: Effects on Lung Aeration and Diaphragm Function
Pulmonary atelectasis and loss of lung aeration are common complications following cardiac surgery with cardiopulmonary bypass (CPB) and are associated with impaired oxygenation and prolonged mechanical ventilation.
- Conditions
- Coronary Artery Disease, Postoperative Pulmonary Complications, Pulmonary Atelectasis, Postoperative, Diaphragm Dysfunction
- Trial name
- FCV-PCV-DTI-LU (NCT07800741)
- Testing
- Flow-Controlled Ventilation, Pressure-Controlled Ventilation (PCV)
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Coronary Artery Disease in Transplanted Heart (Diagnosis), Platelet Dysfunction
Coronary Artery Disease After Heart Transplantation
This study evaluates coronary artery disease after heart transplantation and its relation to platelet function. Furthermore, we will evaluate extracorporeal photopheresis as treatment of coronary artery disease after heart…
- Trial name
- ECP (NCT03583229)
- Testing
- Aspirin 75mg, Extracorporeal photopheresis
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Aarhus University Hospital
Sleep Apnea
Cardiac Dysfunction in Obstructive Sleep Apnea Patients: Prevalence of and Effect of nCPAP
The aim of this study is to clarify the influence of obstructive sleep apnea syndrome on left ventricular function using echocardiographic parameters including the myocardial performance index (Tei-index), and to determine the…
- Trial name
- NCT00503945
- Testing
- Nasal continuous positive airway pressure (nCPAP)
- Where
- Japan
- Volunteers
- 27 people
- Sponsor
- Nagasaki University
Diastolic Dysfunction, Coronary Artery Disease
Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
- Conditions
- Diastolic Dysfunction, Coronary Artery Disease, General Anesthesia
- Trial name
- NCT00907439
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Heart Failure, Systolic, Ketonemia
Ketones in Heart Failure - Effects on Cardiac Efficiency
Ketones may have beneficial effects on myocardial metabolism and hemodynamics. In the present study, healthy test subjects and patients with heart failure with reduced ejections fraction will be investigated in a randomized…
- Trial name
- NCT03073356
- Testing
- Infusion of 3-OHB
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma
Understanding New Cachexia Subtypes Through Observational Epidemiological Research
The UNCOVER study is a longitudinal observational cohort focused on patients at high risk for cancer cachexia. At Kaiser Permanente Northern California, up to 800 individuals with advanced or unresectable non-small cell lung…
- Conditions
- Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Advanced Pancreatic Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- UNCOVER (NCT07776353)
- Testing
- Biospecimen Collection, Computed Tomography, Electronic health record review
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Kaiser Permanente
Cognitive Impairment, Older People--Abuse of
Pre- and Post TAVI Cognitive Functioning and Intraoperative Carotid Flow Measurements
Purpose: 1. Measuring and optimize the usability of the BAMCOG (games to measure cognitive functioning) 2. Concurrent validation of BAMCOG with MoCA to see if BAMCOG can serve as a monitoring instrument/screener 3.
- Conditions
- Cognitive Impairment, Older People--Abuse of, Aortic Stenosis, Severe
- Trial name
- NCT05813353
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Heart Failure, Worsening Heart Failure
Metabolic Changes in Heart Failure Patients Treated With Vericiguat
Heart failure is a condition in which the heart cannot pump blood as effectively as it should. It can cause symptoms such as shortness of breath, tiredness, and fluid retention.
- Conditions
- Heart Failure, Worsening Heart Failure, Heart Failure With Reduced Ejection Fraction
- Trial name
- VERI-MET (NCT07901270)
- Testing
- Vericiguat
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Salerno
Heart; Surgery, Heart, Functional Disturbance as Result, Pediatric ALL
Oblique Versus Transverse Orientation Approach for Internal Jugular Venous Cannulation in Pediatrics
this study aimed to compare oblique versus transverse orientation approach in jugular venous cannulation in term of cannulation success in pediatric heart surgery patients
- Trial name
- NCT05656937
- Testing
- internal jugular venous cannulation
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Ischemic Heart Disease, Myocardial Infarction
Polyamine Treatment in Elderly Patients With Coronary Artery Disease
The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study.
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Cardiovascular Diseases, Hypertensive Heart Disease
- Trial name
- PolyCAD (NCT06186102)
- Testing
- Spermidine
- Where
- Denmark
- Volunteers
- 187 people
- Sponsor
- University of Aarhus
Atrial Fibrillation, T2DM (Type 2 Diabetes Mellitus)
RE-ELECT. Dabigatran vs Warfarin in AF Patients With T2DM and CKD
Kidney function in patients with atrial fibrillation (AF) is tending to decline over a time which is clearly demonstrated in clinical studies.
- Conditions
- Atrial Fibrillation, T2DM (Type 2 Diabetes Mellitus), Chronic Kidney Diseases
- Trial name
- RE-ELECT (NCT03789695)
- Testing
- Dabigatran Etexilate
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Irina Ermolaeva
Acute Coronary Syndrome
Function of High Density Lipoproteins in Acute Coronary Syndromes
High density lipoproteins (HDL) have many effects that protect against cardiovascular diseases. In an acute heart attack (acute coronary syndrome -ACS), HDL change in composition and structure, reflecting the inflammatory…
- Trial name
- HDL_ACS (NCT01278875)
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Heart Rate Variability, Biofeedback, Nicotine Dependence, Nicotine Withdrawal, Anxiety, Depression, Insomnia
Effects of HRV Biofeedback on Autonomic Function and Nicotine Withdrawal Symptoms and Dependence in Smoking Cessation Adults
This study is a randomized controlled trial. It is estimated that 80 quitters will be recruited, and they will be randomly included in the experimental group and 40 in the control group.
- Trial name
- NCT04679636
- Testing
- heart rate variability biofeedback
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Defense Medical Center, Taiwan
Cardiovascular Diseases
Effects of Breaking up Sitting Time on Cardiometabolic Risk Markers and Cardiac Function Post Myocardial Infarction
Cardiovascular Disease (CVD) is one of the greatest causes of mortality and morbidity globally, particularly in middle to high income countries. In the UK alone, it was accountable for 124,641 deaths in 2017.
- Trial name
- MOVE-MI (NCT05193175)
- Testing
- Prolonged sitting
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Bedfordshire
Chest Pain, CAD
Comparing a Diagnostic and Treatment Strategy of Upfront CTCA With SOC in Patients With Chest Pain and Suspected CAD
Rationale: Patients with chest pain usually undergo multiple diagnostic examinations to demonstrate or rule out atherosclerotic coronary artery disease (CAD).
- Trial name
- CLEAR-CAD (NCT05344612)
- Testing
- CT Coronary Angiography
- Where
- Netherlands
- Volunteers
- 6,444 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Psychiatric Diagnosis, Cognition Disorders
Mood and Cognitive Outcome After Heart Transplantation (the MOODHEART Study)
The investigators aim at characterizing neuropsychiatric consequences of heart transplantation (HTX) and at assessing the impact of depressive symptoms after HTX on mortality and cardiac allograft vasculopathy (CAV).
- Trial name
- NCT02035865
- Where
- Norway
- Volunteers
- 74 people
- Sponsor
- Oslo University Hospital
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in centrally obese South Asian and White European men.
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT03952000
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
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