Clinical trials: Functional Cardiac Disorder
Mitral Regurgitation
The Effects of Degenerative Mitral Regurgitation on Cardiac Structure and Function, Symptoms, and Exercise Capacity
Current American College of Cardiology/American Heart Association guidelines recommend that patients with severe degenerative mitral regurgitation be considered for mitral valve surgery.
- Trial name
- NCT04051411
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Atlantic Health System
Left Branch Bundle Block, RV - Right Ventricular Abnormality
Functional Outcomes in CondUction System Pacing and Right Ventricular Synchrony (FOCUS-Right)
The goal of this prospective single center clinical trial is to evaluate the safety and feasibility of performing simultaneous exercise stress cardiac magnetic resonance (CPET-CMR) and cardiopulmonary exercise testing in patients…
- Trial name
- FOCUS-Right (NCT06601322)
- Testing
- Pacemaker Interrogation and Electrocardiogram (ECG):, Cardiopulmonary Exercise Test (CPET) and Exercise Stress Cardiac Magnetic Resonance (ExeCMR, Continuous pacemaker telemetry (CPT)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Virginia Commonwealth University
Right Heart Failure, Mechanical Ventilation
Effect of APRV vs. LTV on Right Heart Function in ARDS Patients: a Single-center Randomized Controlled Study
Acute Respiratory Distress Syndrome (ARDS) is often complicated by Right Ventricular Dysfunction (RVD), and the incidence can be as high as 64%.
- Conditions
- Right Heart Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome
- Trial name
- NCT05922631
- Testing
- Airway pressure release ventilation, low tidal volume
- Where
- China
- Volunteers
- 60 people
- Sponsor
- XiaoJing Zou,MD
Acute Coronary Syndrome, Premature Coronary Heart Disease
Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment
The aim of study is to examine the relationship between lipid subfractions, inflammation and structural-functional properties of the arterial wall in patients with premature coronary heart disease, to study genetic polymorphisms…
- Conditions
- Acute Coronary Syndrome, Premature Coronary Heart Disease, Lipoproteinemia, Inflammation
- Trial name
- GEBI (NCT04613167)
- Testing
- Alirocumab, Evolocumab, Control group
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana
MPS I, MPS IV A
Cardiac Structure and Function in MPS
The purpose of this study is to better understand how heart and blood vessel problems develop in people with Mucopolysaccharidosis (MPS).
- Conditions
- MPS I, MPS IV A, MPS - Mucopolysaccharidosis, MPS IVA
- Trial name
- NCT07361536
- Where
- 3 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Orange County
Polymorphic Ventricular Tachycardia, Heart Failure
Radiofrequency Ablation for Polymorphic Ventricular Tachycardia With Heart Failure (RFCA for PMVT-HF)
This is a prospective, randomized, controlled trial to investigate the efficacy of radiofrequency catheter ablation (RFCA) combined with guideline-directed medical therapy (GDMT) compared to GDMT alone in patients with…
- Trial name
- NCT07130175
- Testing
- Radiofrequency Catheter Ablation, Guideline-Directed Medical Therapy (GDMT)
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Qian Feng
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Effectiveness of an Enhanced Recovery After Surgery Protocol in Patients Undergoing On-pump Cardiac Surgery
In 2019, the Enhanced Recovery After Surgery (ERAS) Society published recommendations for perioperative care in cardiac surgery.
- Trial name
- ERASCs (NCT05225272)
- Testing
- Enhanced Recovery Program for on-pump cardiac surgery
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cardiotoxicity, Childhood Cancer
Prediction of Delayed Toxic Cardiomyopathy in Children
Longitudinal analysis of myocardial function using "Speckle Tracking Echocardiography" STE analysis and prediction of delayed toxic induced cardiomyopathy in young patients who received anthracycline therapy in childhood.
- Trial name
- SpeckleAnthra2 (NCT05781672)
- Testing
- cardiac ultrasound with speckle tracking analysis
- Where
- France
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Non Hodgkin Lymphoma, Heart; Functional Disturbance
Improving Exercise Capacity With a Tailored Physical Activity Intervention
The purpose of this research is to test whether participating in either a physical activity intervention or a series of educational classes will help to preserve exercise capability, heart function, brain-based activities (like…
- Conditions
- Non Hodgkin Lymphoma, Heart; Functional Disturbance, Hodgkin Lymphoma, Quality of Life
- Trial name
- PALS (NCT05595577)
- Testing
- Exercise with Trainerize application, Cardiopulmonary exercise testing, MRI scan
- Where
- 2 sites in United States
- Volunteers
- 105 people
- Sponsor
- Wake Forest University Health Sciences
Acute Coronary Syndrome
Continuous Clopidogrel Dose Adjustment in Acute Coronary Syndrome Patients With High On-treatment Platelet Reactivity
The purpose of this study is to determine whether continuous clopidogrel dose adjustment targeted after platelet function testing improves outcomes during 12 months of follow-up in acute coronary syndrome patients treated with…
- Trial name
- NCT02096419
- Testing
- Clopidogrel dose adjustment
- Where
- Croatia
- Volunteers
- 87 people
- Sponsor
- University of Zagreb
Cardiomyopathy
Speckle Tracking in Pediatric Patients
An echocardiogram, also called a cardiac ultrasound or echo, is a medical test that takes pictures of the heart using sound waves. It shows images of the structures of the heart without using radiation.
- Trial name
- NCT00489957
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Emory University
Cardiovascular Diseases
Chronic and Acute Effects of Smoking on the Left and Right Ventricular Relaxation in Young Healthy Smokers
Impairment of relaxation, the early phase of ventricular diastole is the first stage of heart diastolic dysfunction. Left ventricular diastolic function can be determined noninvasively by Echo- Doppler - derived mitral valve flow…
- Trial name
- NCT00395928
- Where
- Poland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction
Home-Based Cardiac Rehabilitation for Patients With Heart Failure
The vast majority of individuals with heart failure do not participate in center based cardiac rehabilitation (CBCR). While steps to increase utilization of CBCR are important, many individuals will still not participate for a…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Cardiovascular Diseases
- Trial name
- MOBILE HEART (NCT06479876)
- Testing
- HBCR
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Coronary Artery Disease
Effect of 6R-BH4 Treatment in Coronary Artery Disease (OXBIO Study)
The purpose of this study is to determine the effect of 6R-BH4 on vascular function in patients with coronary artery disease. We hypothesize that 6R-BH4 will improve vascular function in these patients.
- Trial name
- NCT00423280
- Testing
- 6R-BH4
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Oxford
Coronary Artery Disease, CABG
Clinimetric Properties of Performance Based Functional Outcome Measure After (CABG) Surgery
The purpose of this research is to determine which performance based functional outcome test among Time up and go test, Five times sit to stand test, 2 minute walk test and 6 minute walk test has the greatest significance in…
- Trial name
- NCT07060937
- Testing
- Physiotherapy Protocol
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- Riphah International University
Anemia
(ACORD Study) - A Study of NeoRecormon (Epoetin Beta) in Patients With Early Diabetic Nephropathy
This study will assess the effect of anemia correction with NeoRecormon on cardiac structure and function in patients with early diabetic nephropathy.
- Trial name
- NCT00354341
- Testing
- Epoetin beta
- Where
- 63 sites in Austria, Brazil and 15 more
- Volunteers
- 170 people
- Sponsor
- Hoffmann-La Roche
Heart Failure, Congestive
Renal Effects of Intrarenal Nesiritide
The impact of nesiritide in CHF is unclear, but it is possible that systemic vasodilation leads to adverse consequences even if the direct renal effects are positive.
- Trial name
- NCT00270829
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Coronary Disease
Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel
In recent years numerous studies have shown that the response of patients to the anti-platelet drug clopidogrel is widely variable.
- Trial name
- MATTIS-D (NCT01643031)
- Testing
- Ticagrelor, Continued clopidogrel
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus Type 2, Diastolic Dysfunction
Effect of Liraglutide on Diastolic Dysfunction on Cardiac MRI in Type 2 Diabetes Patients
The purpose of this study is to determine whether liraglutide a GLP-1 analogue are effective in the treatment of diastolic dysfunction in type 2 diabetes patients analyzed by cardiac MRI.
- Conditions
- Diabetes Mellitus Type 2, Diastolic Dysfunction, Cardiac MRI, Myocardial Perfusion
- Trial name
- NCT02655770
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Tricuspid Regurgitation Functional, Tricuspid Regurgitation
The STTAR-US Study: A Pivotal Study of Transcatheter Tricuspid Annular Repair in the US
Purpose of this clinical study is to demonstrate the safety and efficacy of MIA-T system in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR grade ≥3) despite optimal medical therapy…
- Conditions
- Tricuspid Regurgitation Functional, Tricuspid Regurgitation, Severe Tricuspid Valve Regurgitation
- Trial name
- STTAR-US (NCT06700239)
- Testing
- MIA_T Device
- Volunteers
- 600 people
- Sponsor
- Micro Interventional Devices
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