Clinical trials: Functional Cardiac Disorder
Heart Failure
Clinical Status Monitoring in Implantable Cardiac Defibrillator (ICD) Patients by Physiological Diagnosis (PhD) Function
The purpose of this study is to evaluate the performance of advanced features, that have been implemented in the PARADYM ICD Platform offering single chamber (VR - model 8250), dual Chamber (DR - 8550) and Cardiac…
- Trial name
- TUTOR (NCT01170624)
- Testing
- ICD
- Where
- 25 sites in Belgium, France and 3 more
- Volunteers
- 388 people
- Sponsor
- LivaNova
Spinal Muscular Atrophy
Spinal Muscular Atrophy and Cardiac Autonomic Function
Respiratory dysfunction is the major cause of morbidity and mortality in patients with spinal muscular atrophy (SMA). Air stacking is a clearance airway technique frequently used but its effects on cardiac autonomic function in…
- Trial name
- NCT01522079
- Testing
- Air stacking manuever
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Centro Universitário Augusto Motta
Coronary Artery Disease, Coronary Artery Disease (CAD)
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD), Multivessel Coronary Artery Disease, CABG
- Trial name
- STICH 3*0-NL (NCT07269366)
- Testing
- CABG, PCI
- Where
- Netherlands
- Volunteers
- 358 people
- Sponsor
- University Medical Center Groningen
Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D)
Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia
This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI/D) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history.
- Conditions
- Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D), Cardiac Remodeling
- Trial name
- HEART_REMOD_AD (NCT07456722)
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Pulmonary Arterial Hypertension (PAH)
The PAH Disability and Bothersomeness Questionnaire
To develop a patient-reported questionnaire to investigate the impact of PAH (pulmonary arterial hypertension) on patients' daily lives in terms of bothersomeness and disability.
- Trial name
- PAH-DBoQ (NCT03235401)
- Testing
- 37-items questionnaire
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Association de Recherche en Physiopathologie Respiratoire
Myocardial Infarction, Inflammation
Simvastatin Effect on Inflammation and Endothelial Function After Myocardial Infarction
During myocardial infarction, inflammatory response may negatively influence ventricle wall remodeling as well as endothelium-dependent vasomotor function in the coronary and systemic arterial systems.
- Conditions
- Myocardial Infarction, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00906451
- Testing
- Simvastatin
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Brasilia Heart Study Group
Acute Coronary Syndrome
Function of High Density Lipoproteins in Acute Coronary Syndromes
High density lipoproteins (HDL) have many effects that protect against cardiovascular diseases. In an acute heart attack (acute coronary syndrome -ACS), HDL change in composition and structure, reflecting the inflammatory…
- Trial name
- HDL_ACS (NCT01278875)
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diastolic Heart Failure, Diastolic Dysfunction
CORolla® TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD)
The study objective is to demonstrate safety and feasibility of the CORolla® TAA during 12 months of follow up, and to evaluate the performance of the therapy in relieving symptoms and restore diastolic function in patients with…
- Trial name
- NCT02499601
- Testing
- CORolla™ TAA device
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- CorAssist Cadiovascular Ltd.
Cardiovascular Disease
Acute Heart Health Benefits of Whole Grain Barley and Oats in Healthy Men and Women
The objectives of this study are the following: 1) to determine the acute effect of whole grain barley on risk factors of cardiovascular disease compared to a diet low in whole grain, and 2) to compare the effects of whole grain…
- Trial name
- NCT01283672
- Testing
- Controlled diet with whole grain barley, whole grain oats, or low grain diet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)
Heart Failure
Chronic Sildenafil Treatment in Heart Failure
In heart failure (HF), a defective nitric oxide (NO) signaling may be involved in left ventricular (LV) diastolic abnormalities and LV remodelling progression.
- Trial name
- NCT00975494
- Testing
- Sildenafil
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
Chronic Heart Failure, Central Sleep Apnea
Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes Respiration
Sleep disordered breathing is common in patients with chronic heart failure. Adaptive servoventilation is a novel method of treatment central sleep apnoea, especially associated with Cheyne-Stokes-respiration.
- Conditions
- Chronic Heart Failure, Central Sleep Apnea, Cheyne-Stokes Respiration
- Trial name
- NCT01212705
- Testing
- Adaptive servoventilation
- Where
- Poland
- Sponsor
- Military Institute od Medicine National Research Institute
Obesity and Type 2 Diabetes
Effects of Enavogliflozin on Coronary Microvascular and Cardiac Function in Obesity
The goal of this study is to analyze the effects of enavogliflozin on heart function and coronary microvascular function in obese patients compared to a placebo, and to evaluate the improvement in cardiopulmonary exercise…
- Trial name
- ENVY (NCT06782139)
- Testing
- Enavogliflozin
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Korea University Anam Hospital
Atherosclerotic Cardiovascular Disease
Effect of Evolocumab on Vascular Function
This is a phase IV, randomized (1:1), prospective, double-blind, placebo controlled, parallel-group, single center study at the Clinical Research Unit (CRC) of the Department of Nephrology and Hypertension, with its two separate…
- Trial name
- EVO (NCT03626831)
- Testing
- Evolocumab Prefilled Syringe
- Where
- Germany
- Volunteers
- 105 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Heart; Disease, Mitral(Valve)
Rapid and Easy Evaluation of Cardiac Systolic Function by Means of Mitral Valve Movements in the Emergency Department
Left ventricular ejection fraction (LVEF) is a parameter that should be evaluated rapidly to the patients, admitted to the emergency department with shortness of breath.
- Trial name
- NCT02657824
- Testing
- dyspneic patients
- Volunteers
- 113 people
- Sponsor
- Bozyaka Training and Research Hospital
Stroke, Post-stroke Depression
Physical Capacity Building for Chronic Stroke
Cardiac rehabilitation is the standard-of-care treatment option for patients with cardiovascular disease and has been shown to improve many aspects critical to patient recovery.
- Trial name
- NCT07039305
- Testing
- Physical capacity training for chronic stroke - building aerobic capacity and muscle strength
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Chronic Kidney Diseases
Effects of Dapagliflozin on EChOcardiographic Measures of CarDiac StructurE and Function in Patients with CKD
The purpose of this study is to investigate the effects of dapagliflozin on echocardiographic measures of cardiac structure and function in patients with chronic kidney disease.
- Trial name
- DECODE-CKD (NCT05359263)
- Testing
- Dapagliflozin 10 mg
- Where
- Denmark
- Volunteers
- 222 people
- Sponsor
- Tor Biering-Sørensen
Single-ventricle
Fibrosis and the Fontan
The purpose of this study is to non-invasively characterize the fibrotic consequences of single ventricle physiology, its possible solution and effect on lymphatics.
- Trial name
- NCT04901975
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Children's Hospital of Philadelphia
Anemia, Cardiovascular Disease
An Exploratory Sub-study for the RED-HF™ (Reduction of Events With Darbepoetin Alfa in Heart Failure) Trial
The purpose of Study 20060172 was to measure echocardiographic parameters and biomarkers in a subgroup of study subjects enrolled in Study 20050222 (the RED-HF Trial).
- Conditions
- Anemia, Cardiovascular Disease, Congestive Heart Failure, Heart Failure
- Trial name
- NCT00534456
- Testing
- Darbepoetin alfa
- Volunteers
- 12 people
- Sponsor
- Amgen
Heart Failure, Congestive
PET Scan to Determine Areas of Blood Flow and Activity in the Hearts of Patients With Heart Disease Taking Beta-Blockers
The human heart is divided into four chambers. One of the four chambers, the left ventricle, is the chamber mainly responsible for pumping blood out of the heart into the circulation.
- Trial name
- NCT00001402
- Testing
- PET scan
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Functional Mitral Regurgitation
Percutaneous Left Ventricular Reshaping to Reduce Functional Mitral Regurgitation and Improve LV Function
The study is designed to demonstrate the safety, feasibility and potential efficacy of using the AccuCinch® System to reduce functional mitral regurgitation.
- Trial name
- LVRESTORESA (NCT01899573)
- Testing
- AccuCinch® Ventriculoplasty System
- Where
- Colombia
- Volunteers
- 8 people
- Sponsor
- Ancora Heart, Inc.
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