Clinical trials: Functional Cardiac Disorder
Out of Hospital Cardiac Arrest, Inflammatory Response
Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response.
The on-going randomized clinical trial TTM2 (Target Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, NCT02908308) investigates if there is a difference in mortality, neurological function or quality…
- Conditions
- Out of Hospital Cardiac Arrest, Inflammatory Response, Ischemia Reperfusion Injury, Hypothermia
- Trial name
- IH3 (NCT03743584)
- Testing
- Targeted temperature management, Standard care, early treatment of fever
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Platelet Dysfunction Due to Drugs
The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease
This study aims to assess the effects of low dose ticagrelor on platelet function testing in patients with stable coronary artery disease.
- Trial name
- TWIST (NCT04206176)
- Testing
- Ticagrelor
- Where
- Trinidad and Tobago
- Volunteers
- 25 people
- Sponsor
- The University of The West Indies
Coronary Artery Disease, Atherosclerosis
Cardiac Rehabilitation and Coronary Artery Disease
Patients with coronary artery disease (CAD) aged 40-70 years will undergo exercise training (thrice weekly for 12 weeks). A reference group composed of healthy individuals will be included.
- Trial name
- NCT06579807
- Testing
- Exercise training
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
Porphyrias, Hepatic
Acute Intermittent Porphyria Related Abnormalities in Cardiovascular System
This study aims to assess the changes in the cardiovascular system in patients with acute intermittent porphyria (AIP).
- Trial name
- AIPRACUS (NCT05882136)
- Where
- 2 sites in Poland
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Right Ventricular Dysfunction, Rheumatic Heart Disease
Right Ventricular Echo Assessment in Mitral Valve Replacement
Rheumatic heart disease remains a major health problem in developing countries. It is the most important sequel of rheumatic fever and occurs in about 30% of patients with rheumatic fever.Rheumatic heart disease presents with…
- Trial name
- NCT03549052
- Volunteers
- 120 people
- Sponsor
- Assiut University
Cardiomyopathy, Cardiovascular Diseases
Improving Mitral Repair for Functional Mitral Regurgitation
The investigators are interested in determining the best surgical technique to correct functional mitral regurgitation, as there is currently not one technique that is established to work better than the other.
- Conditions
- Cardiomyopathy, Cardiovascular Diseases, Congestive Heart Failure, Coronary Artery Disease
- Trial name
- IMPROVE-FMR (NCT03366649)
- Testing
- Undersizing Mitral Annuloplasty, Papillary Muscle Approximation
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Emory University
Insomnia, Concussion Post Syndrome
Post-Concussion Sleep and Brain-heart Functions
This project is designed as a randomized controlled trial (RCT), with an active control group. Sleep and heart rate will be monitored at home for 1 week before and after the intervention.
- Trial name
- CBT-pI (NCT07636408)
- Testing
- CBT-pI, Sleep Hygiene
- Volunteers
- 70 people
- Sponsor
- University of Ottawa
Cardiovascular Diseases, Heart Diseases
Age, Risk Factors for CVD and Cognitive Functioning
To relate cardiovascular disease (CHD) risk factors to cognitive performance among middle-aged and elderly men and women over a 10 year longitudinal study period.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Neurologic Manifestations
- Trial name
- NCT00007397
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Coronary Arteriosclerosis
Long-Term Effects of Subclinical CAD on Cardiac Function
To assess changes in coronary calcium measured by electron beam computed tomography (EBCT) as a predictor of coronary heart disease (CHD) events.
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases
- Trial name
- NCT00006497
- Sponsor
- University of California, Irvine
Heart Failure
Assessment of Cardiac Functional Reserve in Heart Failure With Preserved Ejection Fraction (HF-PEF)
This study will compare the ability of the heart to increase its contractile performance during stress in patients with a history of heart failure without systolic dysfunction and in controls.
- Trial name
- DobStress (NCT00585806)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Coronary Disease, Heart Failure
Functional Electrical Stimulation in Cardiac Patients
The purpose of this study was to determine the effects of Functional Electrical Stimulation (FES) on physical performance and quality of life of patients in cardiac rehabilitation.
- Trial name
- NCT02088138
- Testing
- Functional Electrical Stimulation
- Where
- 3 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Prof. Dr. Antônio Marcos Vargas da Silva
Fibromyalgia
Effectiveness of Tai Chi on Cardiac Autonomic Function and Symptomatology in Women With Fibromyalgia: a Randomized Controlled Trial
Fibromyalgia (FM) is an idiopathic disease affecting approximately 3% of the world population, primarily diagnosed in middle-aged women.
- Trial name
- NCT03016585
- Testing
- Tai Chi Training
- Volunteers
- 37 people
- Sponsor
- Pusan National University
Heart Failure, Preserved Ejection Fraction
The Efficacy of Enavogliflozin in Heart Failure With Preserved Ejection Fraction
The aim of prospective, open label, single center, randomized controlled trial is to investigate the efficacy of enavogliflozin on exercise performance, diastolic dysfunction, and quality of life in patients with heart failure…
- Trial name
- ENRICH-PEF (NCT06350487)
- Testing
- SGLT2 inhibitor
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Samsung Medical Center
Cognitive Impairment, Cardiac Disease
Cognitive Function in Adults With Cardiac Disease
The purpose of this study is to identify cardiac patients' degree of unappreciated mild impairment in cognitive function patterns of cognitive function, and influencing factors related to cognitive functioning during…
- Trial name
- TimePoints (NCT01043315)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University Hospitals Cleveland Medical Center
Heart Failure, Pulmonary Disease, Chronic Obstructive
Pulmonary Function, Chronic Obstructive Pulmonary Disease (COPD) Prevalence, and Systemic Inflammation in Chronic Heart Failure With or Without COPD
The aim of the present study is: 1. To investigate pulmonary function abnormalities (restriction, obstruction, diffusion impairment, mixed pulmonary defects) in patients with chronic heart failure (CHF) and to determine which of…
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Inflammation
- Trial name
- NCT01429376
- Testing
- Pulmonary function tests, Blood tests, Questionnaires
- Where
- 2 sites in Netherlands
- Volunteers
- 234 people
- Sponsor
- Rijnstate Hospital
Coronary Artery Disease, Acute Coronary Syndrome
PAR Regulation of Platelet Function in Diabetic Patients
Thrombin is the most potent activator of platelets, and platelet activation is a hallmark of thrombosis. Coronary artery disease (CAD) is the major cause of mortality and morbidity in the United States and other industrialized…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Diabetes, Metabolic Syndrome
- Trial name
- NCT00855374
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Acute Myocardial Infarction, Myocardial Reperfusion Injury
Optimized Cardioprotection Therapy in Obese Subjects With AMI
The purpose of this study is to investigate the efficacy and mechanism of Adipokines Cardiac Protection in Obese Patients With acute myocardial infarction (AMI) Who Have Undergone Percutaneous Coronary Intervention (PCI).
- Conditions
- Acute Myocardial Infarction, Myocardial Reperfusion Injury, Obesity, Adiposis; Heart
- Trial name
- NCT04570514
- Testing
- PCI
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Heart Failure, Recent Onset Atrial Fibrillation
The Comparison With Clinical Impacts on Functional Capacity and Symptom Improvement According to the Rhythm Control in Patients With Heart Failure and Recent Onset Atrial Fibrillation
Prospective randomized (rhythm control or rate control in heart failure patients with new onset atrial fibrillation) Objective of study 1.
- Trial name
- NCT02321085
- Testing
- Sinus Rhythm control, Pulse Rate control
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Yonsei University
Ventricular Tachycardia, Sudden Cardiac Death
Functional Substrate-Only Guided VT Ablation
Ventricular tachycardia (VT) is a leading cause of death and suffering in the Veteran population. Currently, ablation procedures are performed to destroy the diseased tissue that causes this problem.
- Trial name
- SLO-VT (NCT06464315)
- Testing
- Functional Substrate-Only Mapping without VT Induction, Standard-of-Care Mapping/Imaging
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Out-of-hospital Cardiac Arrest
Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest
ILCOR guidelines recommend Target Temperature Management (TTM) to between 32°C and 36°C after out-of-hospital cardiac arrest, based on low quality evidence.
- Trial name
- TTM-2 (NCT02908308)
- Testing
- Targeted temperature management to 33°C, Standard care with early treatment of fever
- Where
- 60 sites in United States, Australia and 12 more
- Volunteers
- 1,900 people
- Sponsor
- Helsingborgs Hospital
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