Clinical trials: Functional Cardiac Disorder
Impaired Glucose Tolerance
Physical Exercise Versus Rosiglitazone in CAD and Prediabetes
The aim of this study is to prospectively assess the relative benefits of either treatment with rosiglitazone or physical exercise on endothelial function in patients with impaired fasting glucose or impaired glucose tolerance…
- Trial name
- NCT00675740
- Testing
- rosiglitazone, physical exercise, control
- Volunteers
- 45 people
- Sponsor
- University of Leipzig
Out-of-hospital Cardiac Arrest
Target Temperature Management After Cardiac Arrest
Experimental studies and previous clinical trials suggest an improvement in mortality and neurological function with hypothermia after cardiac arrest.
- Trial name
- TTM (NCT01020916)
- Testing
- Target temperature 36°C, Target Temperature 33°C
- Where
- 33 sites in Australia, Czechia and 8 more
- Volunteers
- 950 people
- Sponsor
- Niklas Nielsen
Atrial Fibrillation
The Relationship Between Left Atrial Pressure and Cardiac Function After Atrioventricular Node Ablation
Effects of left atrial pressure-guided ventricular rate changes on cardiac function after atrioventricular node ablation combined with left bundle branch pacing
- Trial name
- LAP-TOP (NCT05449158)
- Testing
- left atrial pressure regulation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai 10th People's Hospital
Cardiomyopathy, Dilated
Clinical Observation of Long-term Cardiac Function Prognosis in Patients With PPCM Who Have Recovered Cardiac Function
Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that occurs in late pregnancy and early postnatal period, which is mainly characterized by varying degrees of impaired ventricular systolic function and symptoms…
- Trial name
- NCT06039072
- Testing
- Patients with cardiac function recovered for more than one year and discontinued were in the discontinuation group.
- Volunteers
- 120 people
- Sponsor
- Qilu Hospital of Shandong University
Type 2 Diabetes Mellitus
Vascular Function and Biomarker Assessments in Healthy Volunteers and in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the vascular function and biomarkers in healthy volunteers and type 2 diabetic patients.
- Trial name
- NCT04744636
- Testing
- Other
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Internationales Servier
Coronary Artery Disease
DRUG RELEASING BALL vs. PHARMACOACTIVE STENT IN LARGE VESSELS: MORPHOLOGICAL ANALYSIS AND FUNCTION VASOMOTOR (DEBORA STUDY) IN LARGE VESSELS: MORPHOLOGICAL ANALYSIS AND FUNCTION VASOMOTOR (DEBORA STUDY)
Randomized, controlled, open and multicenter study that analyzes the vasomotor function 8 months after use of the drug-eluting balloon (DCB) vs. drug-eluting stent (DES) in vessels ≥ 3.5 mm
- Trial name
- NCT06448637
- Testing
- Drug Coated Balloon (DCB), Drug Eluting Stent (DES)
- Where
- 9 sites in Spain
- Volunteers
- 94 people
- Sponsor
- Fundación EPIC
Congenital Heart Defects, Growth Failure
Intestinal Function in Neonates With Complex Congenital Heart Disease
Postnatal intestinal function in cardiac infants. The overall goal of this proposal is to address a widespread health problem in the pediatric cardiac infant population - poor postnatal growth - through a collaborative effort…
- Trial name
- NCT01475357
- Testing
- Arm 1: NPO by mouth pre-operative, Arm 2: Fresh Breast Milk pre-operative
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Medical University of South Carolina
Type2 Diabetes, Heart Failure
Impact of a Short-term Treatment With Canagliflozin (Canacardia-HF)
It is a mechanistic proof-of-concept study to demonstrate how SGLT-2 inhibitors (Canagliflozin) may have a beneficial role on cardiac energetic efficiency.
- Trial name
- Canacardia (NCT03298009)
- Testing
- Canagliflozin 100mg, PET imaging
- Sponsor
- Université de Sherbrooke
Coronary Occlusion, Acute Coronary Syndrome
Hemoglobin Based Oxygen Therapeutics in Elective Percutaneous Coronary Revascularization
The test compound and subject of this clinical trial is the haemoglobin-based oxygen carrier, HBOC-201 (Hemopure). HBOC-201, initially developed as an alternative to red blood cells for surgical patients, has the ability to…
- Trial name
- NCT00479895
- Testing
- Hemoglobin Based Oxygen Carrier-201 (HBOC-201, Hemopure)
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Biopure Corporation
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Cardiovascular Diseases
NITRATE-OCT-CIN (Sub-Study of NITRATE-OCT)
The NITRATE-OCT:- Contrast Nephropathy Sub-study is a proof-of concept single center, randomized, clinical trial designed to ascertain whether a dietary NO3- approach might prove useful adjunctive therapy improving renal function…
- Trial name
- NIT-OCT-CIN (NCT05544981)
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Queen Mary University of London
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Heart Failure
Effect of Rapamycin to Improve Cardiac Function in Frail Older Adults
The purpose of this research is to see if the drug rapamycin will improve the heart's ability to pump by improving your oxygen consumption.
- Trial name
- NCT04996719
- Testing
- Rapamune
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Congenital Heart Disease (CHD)
Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids
Butyric acid has been shown to promote gut health and improve the microbiome in multiple adult studies. In preliminary studies in older children with inflammatory bowel disease, butyric acid was shown to be safe.
- Trial name
- BASICS-Kids (NCT06882772)
- Testing
- 2 mL SunButyrate-TG, 4 mL SunButyrate-TG
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Nebraska
Diabetes Mellitus, Type 2, Coronary Artery Disease
Assessment of Dapagliflozin Effect on Diabetic Endothelial Dysfunction of Brachial Artery
Background Endothelial dysfunction is one of the early events in atherosclerotic plaque development. It is characterized by an increased ratio of substances with vasoconstrictive, pro-thrombotic, and proliferative properties over…
- Conditions
- Diabetes Mellitus, Type 2, Coronary Artery Disease, Carotid Artery Diseases
- Trial name
- ADDENDA (NCT02919345)
- Testing
- Dapagliflozin 10 mg, Glibenclamide 5 mg
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- University of Campinas, Brazil
Human Immunodeficiency Virus, Coronary Artery Disease
Effect of Evolocumab on Coronary Endothelial Function
The investigators propose a pilot study using (1) MRI to assess coronary artery endothelial function, (2) brachial ultrasound to assess systemic endothelial function, (3) serum markers of inflammation and of endothelial cell…
- Trial name
- EVOLVE (NCT03500302)
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Endothelial Dysfunction
Correlation of Endothelial Function and Early Coronary Artery Disease in Humans
Qualifying patients who are scheduled for angiogram with endothelial function testing are approached to participate in this protocol (consent form reviewed with patient).
- Trial name
- NCT00271492
- Testing
- Atrasentan
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Bradycardia, Syncope, Vasovagal
Comparison of Focal Cryoablation vs. Radiofrequency Cardioneuroablation for Bradyarrhythmias
Bradyarrhythmias are conditions where the heart beats too slowly, causing symptoms like dizziness, fainting, and fatigue. In some patients, these slow heart rhythms are caused by overactivity of the vagus nerve (the part of the…
- Conditions
- Bradycardia, Syncope, Vasovagal, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- CRYO-CNA vs RF (NCT07671898)
- Testing
- Focal Cryoablation, Radiofrequency Catheter Ablation
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Heart Failure; With Decompensation
Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study
A previous study demonstrated that a multidisciplinary cardiac rehabilitation (CR) program was associated with reduced medium- to long-term all-cause mortality in a retrospective propensity score-matched study.
- Trial name
- NCT05498584
- Testing
- exercise based cardiac rehabilitation
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- Chang Gung Memorial Hospital
ARDS, Human, Lung Injury, Acute
Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients
The goal of this interventional crossover study, in intubated and mechanically ventilated Acute Respiratory Distress Syndrome (ARDS) patients, is to compare two positive end-expiratory pressure (PEEP) titration techniques…
- Conditions
- ARDS, Human, Lung Injury, Acute, Respiratory Distress Syndrome, Mechanical Ventilation Complication
- Trial name
- NCT03202641
- Testing
- PEEP ARDSnet, PEEP LRM
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
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