Clinical trials: Functional Cardiac Disorder
Out-Of-Hospital Cardiac Arrest
Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest
The TAME Cardiac Arrest trial will study the ability of higher arterial carbon dioxide (PaCO2) levels to reduce brain damage, comparing giving patients 'normal' to 'slightly higher than normal' blood PaCO2 levels and assessing…
- Trial name
- TAME (NCT03114033)
- Testing
- Targeted therapeutic mild hypercapnia, Targeted normocapnia (Standard care)
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 1,700 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Right Ventricular Dysfunction
TEE 3D RV Assessment for SAVR, Mini AVR, and TAVR
Three-dimensional echocardiography has become a gold standard to assess right ventricular (RV) function, and investigators plan to use 3D transesophageal echocardiography to assess RV function in 3 types of aortic valve…
- Trial name
- NCT05804240
- Testing
- 3D TEE RVEF
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Thomas Jefferson University
Cardiovascular Diseases
Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina
The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery.
- Trial name
- NITRATE-OCT (NCT02529189)
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Queen Mary University of London
Congenital Heart Disease, ICU Acquired Weakness
Muscle Catabolism and Outcomes in Children Following Cardiac Surgery
Background \& Significance. Children with congenital heart disease (CHD) have experienced improved postoperative survival shifting the focus away from minimizing mortality to curtailing morbidities.
- Conditions
- Congenital Heart Disease, ICU Acquired Weakness, Catabolic State
- Trial name
- MOCHI (NCT04998643)
- Testing
- Muscle ultrasound to estimate lean body mass
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston Children's Hospital
Obesity, High Blood Pressure
Effects of Curcumin Supplementation on Gut Barrier Function in Patients With Metabolic Syndrome
This study will investigate the effects of curcumin on the structure/function of the body by investigating whether targeted improvement of intestinal barrier function by supplementation with oral curcumin will result in…
- Conditions
- Obesity, High Blood Pressure, High Cholesterol, Type2 Diabetes
- Trial name
- NCT03542240
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
Cognitive Impairment (CI)
Post-operative Functional Disability in Unrecognized Cognitive Impairment (POF) Study
This is a prospective multicenter cohort study, which will determine the prevalence of preoperative cognitive impairment (CI) using the Modified Telephone Interview for Cognitive Status (TICS-M), Eight-items interview to…
- Trial name
- NCT04850833
- Where
- 2 sites in Canada
- Volunteers
- 390 people
- Sponsor
- University Health Network, Toronto
Heart Failure, Congestive
PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when it is added to IV loop diuretics in…
- Trial name
- NCT00354458
- Testing
- rolofylline
- Volunteers
- 1,102 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Postoperative Complications, Heart Failure
Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery
Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess…
- Trial name
- LIFESAVE (NCT06777355)
- Testing
- Transthoracic and Transesophageal echography within 24 hours post cardiac surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CMC Ambroise Paré
Congenital Heart Disease, Heart; Surgery, Heart, Functional Disturbance as Result
Just TRAC It! Transitioning Responsibly to Adult Care Using Smart Phone Technology
The Just TRAC It! study (Transitioning Responsibly to Adult Care using smart phone technology) is a randomized controlled trial designed to evaluate the impact of using smart phone technology in combination with the nurse led…
- Trial name
- NCT03429335
- Testing
- Teaching session, Just TRAC It!, MyHealth Passport
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- University of Alberta
Acute Myocardial Infarction, Diabetes Mellitus
Coronary Flow Reserve and Glucometabolic State
Diabetes mellitus is a major risk factor for the development of ischemic heart disease, and patients with diabetes mellitus have a worse outcome following an acute myocardial infarction than non-diabetic patients.
- Conditions
- Acute Myocardial Infarction, Diabetes Mellitus, Prediabetes
- Trial name
- NCT00845468
- Where
- Denmark
- Volunteers
- 190 people
- Sponsor
- Medicinsk Forsknings Afdeling
Cardiovascular Disease
The STRETCH Study: Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic Hypertension
The primary objective of the double-blind segment is to compare effects of alagebrium vs placebo on change from baseline in endothelial function, as assessed by flow-mediated vasodilation (FMD).
- Trial name
- NCT00302250
- Testing
- ALT-711 (alagebrium chloride)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Synvista Therapeutics, Inc
Insulin Resistance
Cardiovascular Effects of Metformin on Obesity
It has been shown that asymptomatic obese adolescents can demonstrate abnormal regional myocardial contraction, with preserved global cardiac function.
- Trial name
- NCT01910246
- Testing
- Metformin
- Where
- United States
- Sponsor
- University of California, San Francisco
Diffuse Large B-cell Lymphoma
R-CMOP in Patients With Primary Diffuse Large B-cell Lymphoma
To evaluate the efficacy and safety of R-CMOP regimen based on mitoxantrone hydrochloride liposome injection in the treatment of newly diagnosed diffuse large B-cell lymphoma (DLBCL) based on cardiac function screening
- Trial name
- NCT05777369
- Testing
- Rituximab, Mitoxantrone hydrochloride liposome, Cyclophosphamide
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Angina, Stable, Angina Pectoris, Variant
Coronary Microvascular Function and CT Coronary Angiography (CorCTCA)
Angina in patients without obstructive coronary artery disease (CAD) is a clinical conundrum and patient management is heterogeneous. Hypothesis: Abnormal coronary function is common and clinically relevant in this population.
- Conditions
- Angina, Stable, Angina Pectoris, Variant, Microvascular Angina
- Trial name
- CorCTCA (NCT03477890)
- Testing
- Stratified medicine involving a diagnostic intervention
- Where
- 3 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- NHS National Waiting Times Centre Board
Migraine Disorders, Patent Foramen Ovale
Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine
Patent Foramen Ovale (PFO) is a common congenital heart defect. Recent studies have suggested a potential association between PFO and migraines, particularly migraine with aura.
- Conditions
- Migraine Disorders, Patent Foramen Ovale, Right-to-Left Shunt, Cardiac
- Trial name
- NCT07170176
- Testing
- Percutaneous Patent Foramen Ovale Closure, No Intervention
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram
Endothelin Role In COronary Microcirculation
Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries.
- Conditions
- Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram, Microvascular Angina
- Trial name
- ERICOM (NCT07670091)
- Testing
- Cardiac MRI, Invasive Coronary Angiogram, Endothelin Receptor Antagonist
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Coronary Artery Disease
Effectiveness of Early Cardiac Rehabilitation
The goal of this experimental study is to compare the effects of early (2nd week) cardiac rehabilitation applied in addition to usual care on functional capacity, quality of life, frailty and body composition in patients…
- Trial name
- NCT06116773
- Testing
- Training, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Functional Mitral Regurgitation
Percutaneous Left Ventricular Reshaping to Reduce Functional Mitral Regurgitation and Improve LV Function
The study is designed to demonstrate the safety, feasibility and potential efficacy of using the AccuCinch® System to reduce functional mitral regurgitation.
- Trial name
- LVRESTORESA (NCT01899573)
- Testing
- AccuCinch® Ventriculoplasty System
- Where
- Colombia
- Volunteers
- 8 people
- Sponsor
- Ancora Heart, Inc.
Heart Failure, Functional Status
Home Walking Exercise Training in Advanced Heart Failure
Heart failure is a major public health burden in the United States characterized by increased morbidity and mortality, and reduce exercise capacity with distressing symptoms of dyspnea and fatigue.
- Conditions
- Heart Failure, Functional Status, Quality of Life
- Trial name
- NCT00012883
- Testing
- Homewalking exercise program
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- US Department of Veterans Affairs
Hypoplastic Left Heart Syndrome, Tetralogy of Fallot
Examining Developmental Changes in Heart Contractions of Children With Congenital Heart Defects
Children who are born with heart defects undergo surgery when they are infants to correct the defects. However, many treatments that are used in pediatric heart patients were originally developed for adults and may not be the…
- Trial name
- NCT00860327
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Emory University