Clinical trials: Functional Cardiac Disorder
Heart Defects, Congenital, Executive Dysfunction
EF Intervention in Children With Severe Congenital Heart Disease
Survival rates of children with severe congenital heart disease (CHD) have increased with ongoing medical progress over the past decades.
- Trial name
- E-FIT (NCT05198583)
- Testing
- E-Fit
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University Children's Hospital, Zurich
Left Ventricular Hypertrophy
Postnatal Steroids Effects on Cardiac Function in Extremely Preterm
Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects…
- Trial name
- SPEC (NCT04644094)
- Testing
- Echocardiography (ECHO) and lung ultrasound (LUS) studies before and after Dexamethasone administration
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Congestive Heart Failure
Study to Evaluate the Safety of Twice Daily Oral Carvedilol
The objective of this study is to evaluate the long-term safety of carvedilol in pediatric patients with chronic heart failure, who completed the Pediatric Carvedilol Study 321.
- Trial name
- NCT00129363
- Testing
- Carvedilol
- Where
- 17 sites in United States
- Volunteers
- 75 people
- Sponsor
- Shaddy, Robert, M.D.
Acute Renal Failure (ARF)
Venous Congestion and Acute Renal Failure in Cardiac Surgery Postoperative
Acute renal failure (ARF) is a frequent complication in the postoperative cardiac surgery, and is a major risk factor for mortality in this context.
- Trial name
- COVD (NCT03013621)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Severe Functional Mitral Regurgitation and Heart Failure
Feasibility of the AccuCinch® System for Left Ventricular Reshaping of the Mitral Apparatus to Reduce Functional Mitral Regurgitation and Improve Left Ventricular Function
To assess the safety and performance of the GDS Accucinch System when used percutaneously to reduce functional mitral regurgitation.
- Trial name
- LVRECOVER (NCT02153892)
- Testing
- GDS Accucinch System
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- Ancora Heart, Inc.
Frailty Syndrome, Quality of Life
Feasibility and Effectiveness of an Additional Resistance and Balance Training in Cardiac Rehabilitation of Older Patients After Valve Surgery or Intervention
The aim of the study is to evaluate the short- and medium-term effectiveness of additional moderate dynamic resistance and balance training to the CR-program of old adults after valve surgery or intervention compared to usual…
- Conditions
- Frailty Syndrome, Quality of Life, Valve Heart Disease
- Trial name
- NCT04234087
- Testing
- Additional balance and resistance training
- Where
- Lithuania
- Volunteers
- 116 people
- Sponsor
- Lithuanian University of Health Sciences
Ventricular Dysfunction, Right, Lung Diseases
Evaluation of the Right Ventricular Systolic Function Using Real-time Three-dimensional Echocardiography in Intensive Care Unit Patients
Right ventricular failure (RVF) is an independent factor of mortality for many pulmonary diseases. Currently, RVF is defined as the incapacity of the RV to maintain the flow without dilating to use the Frank-Starling law (i.e.…
- Conditions
- Ventricular Dysfunction, Right, Lung Diseases, Intensive Care Units
- Trial name
- REA-3D-VD (NCT04222764)
- Testing
- Real-time three-dimensional echocardiography
- Where
- 2 sites in France
- Volunteers
- 341 people
- Sponsor
- University Hospital, Limoges
Type 2 Diabetes Mellitus
Vascular Function and Biomarker Assessments in Healthy Volunteers and in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the vascular function and biomarkers in healthy volunteers and type 2 diabetic patients.
- Trial name
- NCT04744636
- Testing
- Other
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Internationales Servier
Heart Failure, Dilated Cardiomyopathy
Brain Function and Perfusion in Patients With Heart Failure
The investigators will evaluate the determinants of cerebral impairment in patients with non-ischemic heart failure compared to controls, and its relation to cognitive function.
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Perfusion, Cognitive Impairment
- Trial name
- BRAIN-HF (NCT01756014)
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Core Temperature, Telomere Length, Mean Leukocyte
Mitigating Heat Stress Among Rickshaw Drivers in Bangladesh
The goal of the experimental study is to understand the impact of heat stress on core temperature and telomere length. Investigators will recruit rickshaw drivers who use manual power to push their rickshaws and randomly assign…
- Conditions
- Core Temperature, Telomere Length, Mean Leukocyte, Kidney Function Issue
- Trial name
- NCT06956430
- Testing
- Battery-powered rickshaw
- Volunteers
- 300 people
- Sponsor
- University of California, Berkeley
Functional Mitral Regurgitation, Atrial Fibrillation
An Initial Evaluation of the Carillon Mitral Contour System for Treatment of Atrial Function Mitral Regurgitation
The objective of this prospective, multi-center trial is to assess the effectiveness of the CARILLON Mitral Contour System in treating patients with moderate-to-severe atrial functional mitral regurgitation (aFMR)
- Conditions
- Functional Mitral Regurgitation, Atrial Fibrillation, Atrial Functional Mitral Regurgitation
- Trial name
- AFIRE (NCT04529928)
- Testing
- Carillon Mitral Contour System
- Where
- 2 sites in Australia, Greece
- Volunteers
- 4 people
- Sponsor
- Cardiac Dimensions Pty Ltd
Stroke
Tai Chi Training in Stroke Survivors
People with stroke suffer from different impairments, including the ability to dual-tasking, increased arterial stiffness, and dysfunction of the autonomic nervous system.
- Trial name
- NCT03252236
- Testing
- Tai Chi, Conventional exercise
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The Hong Kong Polytechnic University
Lymphatic Abnormalities, Lymphatic Edema
Lymphatic Function in Patients With a Fontan-Kreutzer Circulation
The lymphatics regulate the interstitial fluid by removing excessive fluid. It represents an extremely important step in the prevention of edema.
- Conditions
- Lymphatic Abnormalities, Lymphatic Edema, Univentricular Heart
- Trial name
- NCT03379805
- Testing
- Near Infrared Fluorescence Imaging, Non-contrast MRI, Strain Gauge Plethysmography
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema
Cardiac Function in Swimming-Induced Pulmonary Edema (SIPE)
Acute or chronic cardiac dysfunction could be a contributing factor to swimming-induced pulmonary edema (SIPE). Knowledge on cardiac function in SIPE is limited and recommendations for cardiac evaluation of patients with SIPE are…
- Conditions
- Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema, Lung Diseases, Heart Function Tests
- Trial name
- NCT05391737
- Testing
- Echocardiography, Electrocardiogram (ECG), Cardiac biomarkers
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
Bradycardia, Remote Monitoring
Clinical Assessment of Essential Remote Monitoring Functions in Pacemakers
The purpose of the clinical investigation is to document the safety and the performances of the remote monitoring functions of the ALIZEA, BOREA and CELEA pacemakers, i.e. the RAAT, the RVAT and the remote alerts.
- Trial name
- CALLIOPE (NCT05165095)
- Testing
- Pacemaker implantation
- Where
- 19 sites in Austria, Belgium and 6 more
- Volunteers
- 206 people
- Sponsor
- MicroPort CRM
Cardiovascular Diseases
NITRATE-OCT-CIN (Sub-Study of NITRATE-OCT)
The NITRATE-OCT:- Contrast Nephropathy Sub-study is a proof-of concept single center, randomized, clinical trial designed to ascertain whether a dietary NO3- approach might prove useful adjunctive therapy improving renal function…
- Trial name
- NIT-OCT-CIN (NCT05544981)
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Queen Mary University of London
Spinal Cord Injury
Improving 24-hour Blood Pressure Stability in Spinal Cord Injury With Low Oxygen Therapy
This study examines the effects of low oxygen therapy (LOT) on the stability of 24-hour blood pressure in persons with chronic cervical spinal cord injury.
- Trial name
- NCT06691165
- Testing
- Low oxygen therapy (LOT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Glen Foster
Heart Failure, Type 2 Diabetes
The Effect of Hyperglycemia on LV Function and Exercise Capacity in Diabetics With and Without Heart Failure.
Diabetes and Heart Failure are diseases with high morbidity and increased risk of death. Former investigations has shown that diabetes worsens the prognosis of heart failure.
- Trial name
- METAMOD (NCT01071772)
- Testing
- insulin
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- University of Aarhus
MPS I, MPS IV A
Cardiac Structure and Function in MPS
The purpose of this study is to better understand how heart and blood vessel problems develop in people with Mucopolysaccharidosis (MPS).
- Conditions
- MPS I, MPS IV A, MPS - Mucopolysaccharidosis, MPS IVA
- Trial name
- NCT07361536
- Where
- 3 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Orange County
Heart Failure
The Effect of Omega-3 Polyunsaturated Fatty Acids in Congestive Heart Failure
A diet rich in Omega-3 (fish oil) reduces plasma triglycerides and the risk for ischemic heart disease. Recently, a large trial evaluating treatment with Omega 3 in heart failure patients suggested that omega 3 may lower the risk…
- Trial name
- NCT00944229
- Testing
- LOVAZA (Omega-3)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Columbia University