Clinical trials: Functional Cognitive Disorder
Chronic Heart Failure (CHF)
Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction
This study was a multi-center, randomized, double-blind, parallel group, active comparator trial designed to evaluate the overall effect of LCZ696 compared to valsartan on cognitive function as assessed by the CogState…
- Trial name
- PERSPECTIVE (NCT02884206)
- Testing
- LCZ696, Valsartan
- Where
- 135 sites in United States, Argentina and 18 more
- Volunteers
- 592 people
- Sponsor
- Novartis Pharmaceuticals
Cognitive Function, Preclinical, Chronic Kidney Diseases
Exercise Training and Cognitive Function in Kidney Disease
Chronic kidney disease (CKD), affects over 45% of all individuals over 70 years of age. Patients with moderate CKD have more than a two-fold increased risk of cognitive impairment than those without CKD; furthermore, as many as…
- Conditions
- Cognitive Function, Preclinical, Chronic Kidney Diseases, Older Adults
- Trial name
- NCT03197038
- Testing
- Partially supervised home-based walking exercise, Control
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Cognitive Impairment
GAME Veterans With PTSD Using Computer-Based Cognitive Training
The investigators hypothesis are as follows: H1a: OEF/OIF veterans with PTSD who perform cognitive training (CT) will demonstrate greater objective improvements on standard (untrained) neurocognitive measures, with the largest…
- Trial name
- NCT01087775
- Testing
- Cognitive Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Karen Seal
Migraine With Aura, Patent Foramen Ovale
Comorbidities Associated With Migraine and Patent Foramen Ovale (CAMP)
The purpose of the study is to compare the rate of comorbidities associated with migraine aura (MA) between persons who have a large circulatory right-to-left shunt (RLS) and those who do not have RLS.
- Trial name
- CAMP (NCT01257880)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Swedish Medical Center
Traumatic Brain Injury
Effects of Huperzine A in Treatment of Moderate to Severe TBI
We will explore the use of Huperzine A in patients who have sustained a moderate to severe Traumatic Brain Injury. We aim to determine whether Huperzine A, as compared with placebo, would have an effect on memory function after…
- Trial name
- NCT01676311
- Testing
- Huperzine A
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Spaulding Rehabilitation Hospital
Major Depression, Bipolar Depression
The Use of Galantamine HBr (Reminyl) in Electroconvulsive Therapy: Impact on Mood and Cognitive Functioning
The purpose of the study is to see if galantamine HBr (Razadyne) is safe and can help treat problems with thinking and memory caused by electroconvulsive therapy (ECT).
- Conditions
- Major Depression, Bipolar Depression, Schizoaffective Disorder
- Trial name
- Galantamine (NCT00566735)
- Testing
- Razadyne
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment, Alzheimer Disease
Cerebral Haemodynamic Changes During Cognitive Testing: A fTCD Study
850,000 people live with dementia in the UK, with that number expected to rise to more than 1 million within the next 5 years. The most common type of dementia (55%) is Alzheimer's dementia, and vascular dementia is the second…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Vascular Dementia, Healthy Controls
- Trial name
- NCT03134963
- Testing
- Transcranial doppler ultrasonography, Blood pressure monitoring, Heart rate monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Metabolism - Cerebral Energy
The Efficient Brain Study
Cerebral energy metabolism declines with advanced aging, and is implicated in age-related cognitive decline, Alzheimer's disease (AD), and other forms of neurodegenerative disease (Parkinson's disease).
- Trial name
- NCT02771366
- Testing
- Fermented Papaya Preparation, Granulated Sugar
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cannabis Use Disorder, Cannabis Withdrawal
Progesterone for Cannabis Withdrawal
Sex and gender differences in behavioral, biological, and clinical correlates of substance use disorders are myriad, yet there exists a dearth of gender-informed treatment options.
- Trial name
- NCT03430050
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical University of South Carolina
PTSD
Effects of Mindfulness-Based Cognitive-Behavioral Conjoint Therapy on PTSD and Relationship Function
The purpose of this study is to first adapt Cognitive Behavioral Conjoint Therapy for PTSD for Operation Enduring Freedom and Operation Iraqi Freedom (OEF-OIF) Veterans diagnosed with PTSD and their intimate partners by (1)…
- Trial name
- NCT01035788
- Testing
- Mindfulness Based Cognitive Behavioral Conjoint Therapy, CBCT for PTSD - Communication Skills
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- VA Office of Research and Development
Amyotrophic Lateral Sclerosis
Efficacy and Safety of Plasma Exchange With Albumin in Patients With Amyotrophic Lateral Sclerosis
Pilot, phase II, prospective, open-label, uncontrolled study of plasma exchange with 5% albumin in 10 subjects having a definite, possible, or probable diagnosis of Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT02479802
- Testing
- Albumin
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Instituto Grifols, S.A.
Childhood Traumatic Grief, Post Traumatic Stress
Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya
The primary goal is to study the effectiveness of Trauma-focused Cognitive Behavioral Therapy (TF-CBT) in treating traumatic grief and traumatic stress for orphaned children and young adolescents in two East African sites with…
- Conditions
- Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms
- Trial name
- NCT01822366
- Testing
- Trauma-focused Cognitive Behavioral Therapy
- Where
- 3 sites in United States, Kenya and 1 more
- Volunteers
- 1,280 people
- Sponsor
- Duke University
Cognitive/Functional Effects, Metastatic Cancer
Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
RATIONALE: Radiation therapy uses high energy x-rays to kill tumor cells. PURPOSE: This phase II trial is studying how well avoiding the hippocampus during whole-brain radiation therapy works in treating patients with brain…
- Conditions
- Cognitive/Functional Effects, Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT01227954
- Testing
- intensity-modulated radiation therapy
- Where
- 63 sites in United States, Canada
- Volunteers
- 113 people
- Sponsor
- Radiation Therapy Oncology Group
Depression
Emotional and Cognitive Control in Late-Onset Depression
This study may help identify how abnormalities in brain systems that control the ability to ignore irrelevant information may contribute to the development of depression in older adults.
- Trial name
- NCT01728194
- Testing
- Escitalopram, Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Aging, Cognitive Aging
Impact of Music Improvisation Training on Cognitive Function in Older Adults
This project will develop and test the effects and mechanisms of a music improvisation training intervention on self-regulation of older adults with and without MCI.
- Conditions
- Aging, Cognitive Aging, Cognitive Impairment, Cognitive Training
- Trial name
- NCT05980286
- Testing
- Piano Improvisation, Music Listening
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Psychoses, Substance-Induced
Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids
Ketamine, an FDA approved anesthetic agent, is becoming the sedative/analgesic of choice for emergency sedation in children because it causes deep sedation with minimal respiratory depression in comparison to other available…
- Trial name
- NCT00205712
- Testing
- Ketamine, Dexmedetomidine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment
Effect of Action Observation Training on Gait Variables and Global Cognitive Functions
This study will investigate the effect of Action Observation Teaining (AOT) on gait variables and global cognitive functions in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT03522389
- Testing
- AOT with gait training, Gait training, Education
- Where
- Thailand
- Volunteers
- 39 people
- Sponsor
- Mahidol University
Attention Deficit Hyperactivity Disorder
Safety and Efficacy of GTS21 in Adults With Attention-deficit Hyperactivity Disorder
This study will be a randomized, double-blind, placebo-controlled crossover study to assess the effects of GTS21 (25 mg three times a day (tid), 75 mg tid, 150 mg tid) compared to placebo in non-smoking adults aged 18-55 with a…
- Trial name
- NCT00419445
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- CoMentis
Children, Overweight
The Odense Overweight Intervention Study
Strong and consistent evidence have shown that overweight, including obesity, is an important risk factor for the development of cardiovascular disease (CVD) in adults.
- Conditions
- Children, Overweight, Obesity, Metabolic Syndrome
- Trial name
- OOIS (NCT01574352)
- Testing
- Small intervention, Intervention camp
- Where
- 2 sites in Denmark
- Volunteers
- 115 people
- Sponsor
- University of Southern Denmark
Cognitive Function Abnormal
Boost Study 21270 (Cognition)
This study is designed to to test the technical feasibility of encouraging interaction with a mobile smartphone software package (mHealth app) for training aspects of executive function and cognition.
- Trial name
- NCT05990335
- Testing
- mHealth application (custom)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- NXTech