Clinical trials: Functional Cognitive Disorder
Migraine Headache, Cognitive Impairment
Treximet in Acute Migraine Headache: Assessing Cognitive Function
Migraine headache occurs frequently in women more than men and is associated with symptoms not only of significant pain but also of symptoms typically including of photophobia, phonophobia, nausea and vomiting.
- Trial name
- NCT00837044
- Testing
- Treximet, Migraine rescue medication of choice
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Neurological Research Center
Huntington's Disease
A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD)
The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance and functioning in participants with HD.
- Trial name
- NCT05107128
- Testing
- SAGE-718
- Where
- 49 sites in United States, Australia and 2 more
- Volunteers
- 189 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Heart Failure, Congestive
Heart Failure, Functional and Cognitive Decline, and Psychiatric Symptoms in Nursing Home Patients
Heart failure is very common in the elderly, in whom it may lead to functional and intellectual problems. Functional problems include loss in the ability to perform basic tasks of daily living such as bathing or dressing.
- Trial name
- NCT00182065
- Where
- Canada
- Volunteers
- 586 people
- Sponsor
- McMaster University
Non-Alcoholic Fatty Liver Disease
Hepatic Urea Nitrogen Handling in Patients With NASH
The aim of the project is to investigate the metabolic regulation of the hepatic urea nitrogen handling and various cognitive functions measured by psychometric and neurophysiological tests before and after bariatric surgery in…
- Trial name
- NCT03260036
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Alzheimer's Disease
Safety Study of MT-4666 in Subjects With Alzheimer's Disease
The objective of this study is to evaluate the safety and efficacy of 2 fixed dose of MT-4666 administered once daily for 52 weeks with or without receiving a concomitant acetylcholinesterase inhibitors (AChEIs), in patients with…
- Trial name
- NCT02327182
- Testing
- MT-4666
- Where
- Japan
- Volunteers
- 117 people
- Sponsor
- Tanabe Pharma Corporation
Parkinson Disease, Virtual Reality Therapy
Virtual Reality for Parkinson's Disease
Parkinson's Disease (PD) is one of the most common neurodegenerative disease. Bradykinesia, tremor, resting tremor and postural instability are the main motor characteristics of this disease.
- Conditions
- Parkinson Disease, Virtual Reality Therapy, Functional Magnetic Resonance Imaging
- Trial name
- NCT03637023
- Testing
- Virtual Reality, Exercise Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Farzin Hajebrahimi, PT, MSc
Schizophrenia
Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia
The purpose of study is to determine whether dietary supplement sarcosine is effective in treatment of schizophrenia. The investigators will assess impact of sarcosine on quality of life and sexual functioning.
- Trial name
- PULSAR (NCT01503359)
- Testing
- Sarcosine
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Lodz
Traumatic Brain Injury, Post-Concussive Symptoms
Long-Term Outcomes Following HBOT
This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear…
- Conditions
- Traumatic Brain Injury, Post-Concussive Symptoms, Post-Traumatic Stress Disorder
- Trial name
- NCT07732374
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Summit Hyperbarics and Wellness
Stroke, Cognitive and Attention Disorders and Disturbances
The RenAtt Method for Diagnosing and Treating Attention Problems After Stroke and Brain Injury, Further Validation of RehAtt® DiSTRO Assessment of Cognitive and Visual Function
Stroke is one of the most common long-term disabilities in the world. Despite better access to more effective acute treatment, WHO reports a prediction of almost a doubling of disability-adjusted life-years (DALYs) in 2050.
- Conditions
- Stroke, Cognitive and Attention Disorders and Disturbances, Digital Health, Screening Strategy
- Trial name
- NCT07762274
- Testing
- Oxford Cognitive Screen
- Where
- 3 sites in Italy, Sweden and 1 more
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Umeå University
Bipolar I Disorder
Lurasidone and Cognition in Bipolar I Disorder
This is a 6 week, randomized, open-label, parallel group study in patients with Bipolar-I disorder (manic depression), who are in remission from an episode.
- Trial name
- NCT02147379
- Testing
- Lurasidone
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- University of British Columbia
Mild Cognitive Impairment
Home-Based Dual-Task Training for Older Adults
This project is focused on conducting a home-based, thinking while moving exercise intervention for adults 65 years or older, who have mild cognitive impairment, that will integrate several effective training modalities including…
- Trial name
- NCT05108246
- Testing
- Dual-Task Exercise Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- State University of New York at Buffalo
Obstructive Sleep Apnea, Mild Cognitive Impairment
Sleep Apnea, Neurocognitive Decline and Brain Imaging in Patients With Subjective or Mild Cognitive Impairment
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and potentially lead to cardiometabolic and…
- Conditions
- Obstructive Sleep Apnea, Mild Cognitive Impairment, Subjective Cognitive Impairment
- Trial name
- NCT06150352
- Testing
- Continuous Positive Airway Pressure or other management for OSA per clinical indications.
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- The University of Hong Kong
Psychosis, Schizophrenia
Contrasting Group Therapy Methods for Psychosis
Current Canadian Clinical Practice guidelines emphasize the need for effective psychosocial adjuncts to pharmacotherapy for schizophrenia (Canadian Psychiatric Association 2005).
- Conditions
- Psychosis, Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- MCT (NCT01764568)
- Testing
- Metacognitive Training (MCT), Cognitive Remediation (CR)
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- University of British Columbia
Multiple Sclerosis
Allocentric Memory in MS and Resting State Functional MRI
The goals of this study are to 1. Investigate the sensitivity of allocentric visual memory when compared to more established measures of cognition in identifying cognitive difficulties among MS subjects when compared to controls.
- Trial name
- NCT02118298
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Functional Movement Disorder
CBT Training for Cognitive Reappraisal as an Intervention for Patients With Functional Tremor - an EEG Study
The aim of this psychological study is to evaluate the effect of a cognitive behavioral therapy (CBT) intervention aimed at improving cognitive reappraisal on (1) Clinical and Self-Rated Health according to Patient Global…
- Trial name
- NCT06022393
- Testing
- Cognitive Reappraisal, Reflection
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Cognitive Decline, Dementia
Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults
This study will evaluate the effects of low-intensity strengthening exercise on the brain (thinking and processing speed) for patients with early dementia, compared with normative older adults.
- Conditions
- Cognitive Decline, Dementia, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- NCT01264614
- Testing
- Strengthening exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Union College, New York
Hypertension, Elevated Blood Pressure
Feasibility of a Community-Integrated Isometric Handgrip Exercise Program and Its Preliminary Effects on Blood Pressure and Cognitive Function in Older Adults
The goal of this clinical trial is to evaluate whether a short, supervised isometric handgrip exercise program is feasible and acceptable for older adults with elevated blood pressure or hypertension.
- Trial name
- NCT07648498
- Testing
- Zona Plus 4-Week Isometric Handgrip Exercise Intervention, Squegg 4-Week Isometric Handgrip Exercise Intervention
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Chronic Kidney Disease (Stages 4 and 5), Mild Cognitive Impairment (MCI)
Physical Exercise to Prevent Mild-cognitive Impairment in Patients With Kidney Disfunctions
This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems.
- Trial name
- Exprecoimp-CKD (NCT07160959)
- Testing
- Exercise, Control (Standard treatment)
- Where
- 6 sites in France, Italy and 4 more
- Volunteers
- 124 people
- Sponsor
- Biogem s.c.ar.l.
Mild Cognitive Impairment, Alzheimer Disease
Music Therapy for Patients With Alzheimer's Disease
This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or…
- Trial name
- NCT05151562
- Testing
- Virtual Music Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Healthy
Effects of Donepezil and Memantine on Cognitive Functions After a Sleep Deprivation Challenge in Healthy Volunteers
The aim of this study is to assess the utility of sleep deprivation as a potential model for prediction of clinical efficacy using a combination of cognitive physiological endpoints.
- Trial name
- NCT01461174
- Testing
- Modafinil, Donepezil, Memantine
- Where
- 2 sites in France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Qualissima