Clinical trials: Functional Decline, active
Frailty Syndrome
SHIP-AGE: Frailty, Renal Function, and Multi-component Primary Care in Rural Mecklenburg-Western Pomerania
Chronic kidney disease (CKD) is a leading risk factor for cardiovascular and all-cause mortality among the elderly. Mecklenburg-Western Pomerania has the largest prevalence of CKD in Germany and Europe.
- Trial name
- MV-FIT (NCT05962203)
- Testing
- Multi-factorial geriatric assessment, monitoring & management systems
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
PARKINSON DISEASE (Disorder)
Multicontext Approach for Cognitive Function in Parkinson Disease
Mild cognitive decline is common in early Parkinson disease (PD) and is associated with disability, reduced quality of life (QOL), and increased risk for dementia.
- Trial name
- MC4PD R01 (NCT07190404)
- Testing
- A metacognitive strategy for cognitive rehabilitation called the Multicontext Approach., Cognitive (Process) Training, MC Approach Booster Session
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Washington University School of Medicine
Dementia, Cognitive Dysfunction ( MMSE < 24 )
Animal-Assisted Therapy Combined With Standard Rehabilitation for Motor Recovery in Dementia Patients in a Medical and Rehabilitation Care Unit
The goal of this randomized study is to find out if animal-assisted therapy (AAT) - a structured program where trained animals take part in care sessions guided by health professionals - can help improve movement abilities in…
- Conditions
- Dementia, Cognitive Dysfunction ( MMSE < 24 ), Motor Skills Disorders
- Trial name
- RéMédi - A (NCT07730983)
- Testing
- Animal-Assisted Therapy, Standard psychomotor rehabilitation
- Where
- France
- Volunteers
- 32 people
- Sponsor
- LNA SANTE
Alzheimer's Disease
A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)
The purpose of this study is to measure the difference in time to developing or worsening memory, thinking, or functional problems due to Alzheimer's disease occurring in participants receiving study drug compared to placebo.
- Trial name
- NCT06653153
- Testing
- Remternetug
- Where
- 262 sites in United States, Australia and 8 more
- Volunteers
- 1,400 people
- Sponsor
- Eli Lilly and Company
Cognitive Impairment, Cognitive Decline
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy…
- Trial name
- AIM (NCT05998031)
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Florida
Ageing
Effectiveness of the WHO ICOPE (Integrated Care for Older People) Program in Preventing Age-related Functional Decline (ICOPE Trial.Fr)
The World Health Organization (WHO) has designed an integrated care program (ICOPE) aimed at maintaining the functions of elderly people to preserve their autonomy.
- Trial name
- ICOPE Fr (NCT06676839)
- Testing
- the complete ICOPE program
- Where
- 6 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Toulouse
Dystrophinopathy, Muscular Dystrophies
VirtualPark_Pediatric
The goal of this clinical trial is to assess the effects of a dual-task, multimodal training program on slowing functional motor decline in children and adolescents with neuromuscular disorders.
- Conditions
- Dystrophinopathy, Muscular Dystrophies, Congenital Myopathies
- Trial name
- NCT07580365
- Testing
- Dual-task cycling, Standard therapy
- Where
- 4 sites in Italy
- Volunteers
- 22 people
- Sponsor
- Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato
Ageing and Geriatric Health
Study of Functional Decline and Care Pathways in Neurosurgical Patients Over 65 Years of Age
The GENEUS 1 study addresses this gap by characterizing the real-world profiles, outcomes, and care pathways of adults aged 65 years and older hospitalized in neurosurgery across France, Spain, and Portugal.
- Trial name
- GENEUS 1 (NCT07506941)
- Where
- 6 sites in France, Portugal and 1 more
- Volunteers
- 209 people
- Sponsor
- University Hospital, Toulouse
Social Isolation, SCD
The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
The goal of this clinical trial is to learn about the effects of social isolation and social interaction on the risk of dementia progression and brain function in SCD 1.
- Conditions
- Social Isolation, SCD, Subjective Cognitive Decline, MCI
- Trial name
- NCT06335836
- Testing
- social isolation
- Where
- China
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Aging
The Role of Sirolimus in Preventing Functional Decline in Older Adults
Aging is associated with progressive impairment of tissue and organ function, resulting in increased susceptibility to chronic disease, frailty and disability.
- Trial name
- NCT05237687
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Irina Timofte
Stroke, Hypoalbuminemia
Brief Title: The Role of Nutrition in the Rehabilitation of Patients With Eating Disorders After a Vascular Stroke.
Brief Summary: The main objective of this thesis is to investigate the role of nutrition - specifically the administration of protein supplements (single dose and double dose) - in the rehabilitation of stroke patients with low…
- Conditions
- Stroke, Hypoalbuminemia, Sarcopenia, Osteopenia
- Trial name
- Nutristroke (NCT06961825)
- Testing
- Dietary Supplement
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Ioannina
Cognitive Function, Cognitive Decline
Phospholipid-rich Dairy Extract for Cognitive Function
This clinical trial aims to determine whether dietary phospholipid-rich dairy milk extract improves cognitive function in adults with mild cognitive impairment and to assess its safety.
- Trial name
- NCT07011680
- Testing
- Phospholipid-rich dairy milk extract
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Type 2 Diabetes, Cognitive Decline in Older Adults
Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes
Type 2 diabetes and low levels of physical activity are associated with an increased risk of cognitive decline in older adults. Improving blood sugar control and engaging in regular exercise may help support brain health and…
- Trial name
- MOTIVATE (NCT07485062)
- Testing
- semaglutide, Moderate-Intensity Resistance Exercise, Balance and Tone (BAT) Exercise
- Where
- Canada
- Volunteers
- 164 people
- Sponsor
- Western University, Canada
Frailty, Frail Elderly Syndrome
The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging
This clinical study, designed as a double-blind, randomized, placebo-controlled trial, aims to investigate the potential of nicotinamide riboside (NR) to decelerate functional decline in the elderly frail population.
- Conditions
- Frailty, Frail Elderly Syndrome, Frailty Syndrome, Aging
- Trial name
- NADage (NCT06208527)
- Testing
- Nicotinamide Riboside (NR)
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Functional Decline
Ring Fit Adventure for Functional Decline and Fall Risk in Community-Dwelling Older Adults
Falls and decline in physical function are common problems in community-dwelling older adults. Exercise programs may help improve balance, mobility, and physical function and may reduce fall risk.
- Trial name
- NCT07909564
- Testing
- Ring Fit Adventure-based Exercise Program
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
End-Stage Renal Disease Requiring Haemodialysis
Hemodialysis-Induced Renal Perfusion Decline: Unraveling the Pathophysiological Mechanisms Linking Intradialytic Circulatory Stress to Residual Renal Function Loss
Residual renal function (RRF) plays a critical role in quality of life and survival in hemodialysis (HD) patients but characteristically declines after the initiation of HD.
- Trial name
- HD-RPD (NCT07003828)
- Testing
- CEUS examinations
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yuanjun Yang
Sarcopenia, Frailty
BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline Phase II Aim 4
This study evaluates a home-based strengthening program supported by the BandPass system, which includes a Bluetooth-enabled resistance exercise band, a mobile app that provides real-time feedback, and a clinician dashboard for…
- Trial name
- NCT07421648
- Testing
- BandPass System
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- SynchroHealth LLC
Fall, Daily Activities
Incidence and Factors of Functional Decline After Emergency Department Discharge in Older Adults With Falls
The goal of this observational study is to learn about changes in activities of daily living (ADL) in older adults after being discharged from the emergency department (ED) following a fall.
- Conditions
- Fall, Daily Activities, Functional Decline, Older Adults (65 Years and Older)
- Trial name
- FALL-ADL (NCT07163715)
- Volunteers
- 280 people
- Sponsor
- Ege University
Memory, Cognitive Function
Effect of Daily Mixed Spice Consumption on Memory Function
The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradual and progressive decline in cognitive function.
- Trial name
- NCT06889961
- Testing
- Mixed spices
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Critical Illness, Delirium
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge.
- Conditions
- Critical Illness, Delirium, Cognitive Impairment, Cognitive Decline
- Trial name
- SLEEP-COG (NCT06411561)
- Testing
- SLEEP + COG, COG, SLEEP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington