Clinical trials: Functional Diarrhea
Diarrhea Predominant Irritable Bowel Syndrome
Effect of Ranolazine on Gastrointestinal Motor Function and Pain in Patients With IBS-D
Will Ranolazine improve bowel function and abdominal pain in human subjects with IBS-D?
- Trial name
- Ranolazine (NCT02239926)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Diarrhea-predominant Irritable Bowel Syndrome
Serum-Derived Bovine Immunoglobulin /Protein Isolate (SBI) 5.0 g Bid on Nutritional Status in Subjects With IBS-D
To evaluate the safety and effectiveness of oral nutritional therapy Serum-Derived Bovine Immunoglobulin (SBI) on nutritional status, epithelial barrier function, and mucosal expression of pivotal genes including tight junction…
- Trial name
- NCT02163213
- Testing
- Serum-derived bovine immunoglobulin protein isolate (SBI)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome
Effects of Pectin Supplementation in Diarrhea-predominant Irritable Bowel Syndrome
The purpose of this study is to investigate the effect of pectin, a kind of soluble dietary fiber, on clinical symptoms, gut microbiota and the immune status in patients with diarrhea-predominant irritable bowel syndrome
- Trial name
- NCT02270268
- Testing
- Pectin, maltodextrin
- Volunteers
- 114 people
- Sponsor
- Nanjing PLA General Hospital
Irritable Bowel Syndrome, Functional Diarrhea
Health Education Delivery Methods for a Low Fermentable Carbohydrate Diet in Patients With Functional Bowel Disorders
There is evidence for the use of a diet low in short chain fermentable carbohydrates (low FODMAP diet) in the management of functional gut symptoms, such as abdominal pain and bloating.
- Conditions
- Irritable Bowel Syndrome, Functional Diarrhea, Functional Bowel Disorder
- Trial name
- NCT03694223
- Testing
- Health education delivery methods
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- King's College London
Irritable Bowel Syndrome With Diarrhea
To Compare the Efficacy of Drugs in Combination for Treating Irritable Bowel Syndrome Associated With Diarrhea
The goal of this clinical trial is to compare the efficacy of four different drugs in combination for management of irritable bowel syndrome (IBS)-associated diarrhea.
- Trial name
- NCT05867550
- Testing
- Rifaximin 550 MG, Mebeverine 135 MG, Psyllium Husk
- Where
- Pakistan
- Volunteers
- 162 people
- Sponsor
- Bahria University
Irritable Bowel Syndrome (IBS)
A Phase 2, Multi-center Study to Evaluate the Efficacy and Safety of ONO-2952 in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
The objective of this study is to explore efficacy, safety and tolerability of ONO-2952 in female subjects with Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D).
- Trial name
- RESTORE (NCT01844180)
- Testing
- ONO-2952
- Where
- 48 sites in United States
- Volunteers
- 200 people
- Sponsor
- Ono Pharma USA Inc
Irritable Bowel Syndrome
A Study to Investigate Abdominal Symptoms With Camlipixant Compared With Placebo in Adults With Irritable Bowel Syndrome - Diarrhea (IBS-D) and Irritable Bowel Syndrome - Mixed (IBS-M)
This study is designed to evaluate the efficacy and safety of camlipixant in adults with IBS-D and IBS-M. The study has two parts.
- Trial name
- BALANCE (NCT07519395)
- Testing
- Camlipixant
- Where
- 114 sites in United States
- Volunteers
- 420 people
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome, Diarrhea
Utility of the Administration of Chesnut and Quebracho Extract for Irritable Bowel Syndrome Diarrhea Predominant
Irritable bowel syndrome is a highly prevalent disorder and consumes many health resources. Its physiopathogenesis is multifactorial.
- Trial name
- NCT05207618
- Testing
- ARBOX (QUEBRACHO AND CHESNUT EXTRACT)
- Where
- Argentina
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas José de San Martín
Campylobacter Infections, Irritable Bowel Syndrome
Campylobacter Enteritis and Post-Infective Bowel Dysfunction (PI-BD): Role of Antibiotics and Microbiota
The principal research objective is to determine the impact of antibiotic use on the risk of developing long term bowel symptoms after infection with the germ Campylobacter.
- Trial name
- CERAMIC (NCT02040922)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
Exploratory Study on Dosage of Qizhi Weitong Granules in the Treatment of Irritable Bowel Syndrome （IBS)
The purpose of this study are as follows: 1) To evaluate the efficacy and safety of Qizhi Weitong granules in the treatment of diarrhea-type irritable bowel syndrome (IBS-D);2) To explore the dosage of Qizhi Weitong Granulesin…
- Trial name
- NCT05113888
- Testing
- Qizhi weitong granules(High）, Qizhi weitong granules(Low）
- Volunteers
- 120 people
- Sponsor
- China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.
Irritable Bowel Syndrome With Diarrhea
12-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D)
Irritable Bowel Syndrome with diarrhoea (IBS-D) is a functional gastrointestinal disorder characterised by chronic or recurrent abdominal pain or discomfort and diarrhoea.
- Trial name
- IRIS-3 (NCT02107196)
- Testing
- Ibodutant 10 mg
- Where
- 127 sites in United States, Bulgaria and 9 more
- Volunteers
- 535 people
- Sponsor
- Menarini Group
Irritable Bowel Syndrome
Ayurvedic Herbs in Diarrhea Predominant Irritable Bowel Syndrome
In the present study the investigators are trying to evaluate the effect of Murraya koenigii leaves, Punica granatum and Curcuma which is administered to the patients in a combined form as tea.
- Trial name
- AHIB (NCT01418066)
- Testing
- Ayurvedic Herbs
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Universität Duisburg-Essen
Irritable Bowel Syndrome
Gluten-free Diet in Irritable Bowel Syndrome
To evaluate the effects of a gluten-free diet in irritable bowel syndrome.
- Trial name
- NCT02528929
- Testing
- Gluten-free diet
- Volunteers
- 48 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Irritable Bowel Syndrome
Efficacy and Safety of Saccharomyces Boulardii in the Treatment of Small Intestinal Bacterial Overgrowth
Non-constipated irritable bowel syndrome is a common disorder that may be related to small intestinal bacterial overgrowth. Saccharomyces boulardii CNCM I-745 is a probiotic yeast that has proven efficacy for the treatment of…
- Trial name
- NCT04627337
- Testing
- Saccharomyces Boulardii 250 MG, Dietary advice following a low fermentation diet
- Where
- Argentina
- Volunteers
- 71 people
- Sponsor
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Diarrhea-predominant Irritable Bowel Syndrome
Special Drug Use Surveillance of Irribow in Female Patients
The purpose of the survey is to evaluate the safety and efficacy of Irribow and Irribow OD Tablets in post-marketing medical practice and to examine the status of treatment compliance.
- Trial name
- NCT02612649
- Testing
- Ramosetron
- Where
- 34 sites in Japan
- Volunteers
- 793 people
- Sponsor
- Astellas Pharma Inc
Irritable Bowel Syndrome, Diet Modification
Efficacy of Low-FODMAPs Dietary Therapy for Irritable Bowel Syndrome in China
The primary aim of our study is to carry out a randomized trial to evaluate the efficacy of low-FODMAPs dietary therapy compared to conventional therapy for IBS patients recruited from tertiary hospitals in China.
- Trial name
- NCT03304041
- Testing
- low-FODMAPs diet, Traditional dietary advice
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Sir Run Run Shaw Hospital
Irritable Bowel Syndrome, Diarrhea
Does Welchol (Colesevelam Hydrochloride) Improve Colonic Transit in Diarrhea-predominant Irritable Bowel Syndrome (D-IBS)?
Our hypothesis is that the medication approved for treatment of high blood cholesterol levels, Colesevelam HCl (WELCHOL), decreases colonic transit and permeability in patients with diarrhea due to irritable bowel syndrome.
- Trial name
- welchol (NCT00911612)
- Testing
- Colesevelam
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Intestinal C. Difficile
Probiotic Intervention With Elderly Subjects
The study objective is to evaluate the effect of probiotic on faecal Clostridium difficile levels of elderly subjects.
- Trial name
- NCT01475942
- Testing
- Probiotic
- Where
- Finland
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Danisco
Irritable Bowel Syndrome
A Study of YM060 in Diarrhea-predominant Irritable Bowel Syndrome (d-IBS)
This study will examine the efficacy, safety and tolerability of different oral dose of YM060, 5-HT3 receptor antagonist, in patients with d-IBS.
- Trial name
- NCT00189813
- Testing
- YM060
- Where
- 45 sites in Bulgaria, Czechia and 6 more
- Volunteers
- 691 people
- Sponsor
- Astellas Pharma Inc
Irritable Bowel Syndrome With Diarrhea
Effect of FODMAPs on Mucosal Inflammation in IBS Patients
OBJECTIVE: To gain mechanistic insights, we will compare effects of low fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high FODMAP diets on symptoms and colonic protease expression in…
- Trial name
- NCT03221790
- Testing
- Low FODMAP Diet followed by a High FODMAP Diet
- Volunteers
- 20 people
- Sponsor
- Queen's University