Clinical trials: Functional Disorder of Gastrointestinal Tract
Irritable Bowel Syndrome
Mindfulness for Irritable Bowel Syndrome
This study investigates the effectiveness of a 6 week mindfulness intervention in reducing symptoms of Irritable Bowel Syndrome (IBS). All Participants will receive treatment.
- Trial name
- MIBS (NCT02794376)
- Testing
- Mindfulness Based Cognitive Therapy (MBCT), Waiting Period
- Volunteers
- 67 people
- Sponsor
- University of Oxford
Irritable Bowel Syndrome
Lubiprostone Effects on Visceral Pain Sensitivity
The purpose of this research study is to determine how Lubiprostone, a medication used to treat irritable bowel syndrome with constipation predominant symptoms (IBS-C), works to reduce clinical pain.
- Trial name
- NCT01166789
- Testing
- Lubiprostone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of North Carolina, Chapel Hill
Lower Urinary Tract Symptoms, Gynecologic Malignancy
Prevalence of Lower Urinary Tract Symptoms in Women With Gynecologic Malignancy Planning to Undergo Surgical Management
This study is to determine the prevalence of lower urinary tract symptoms in women undergoing surgery for gynecologic malignancy.
- Trial name
- NCT00580697
- Where
- United States
- Sponsor
- University of California, Irvine
Colorectal Cancer, PDAC - Pancreatic Ductal Adenocarcinoma
Exploratory Clinical Evaluation of Personalized Functional Profiling in GI Tumors: Predicting Drug Response in CRC and PDAC
The ColoPan study evaluates the scientific validity, reproducibility, and predictive performance of the Personalised Functional Profiling (PFP) platform in colorectal cancer and pancreatic ductal adenocarcinoma patients.
- Trial name
- COLOPan (NCT07500259)
- Testing
- Personalized Functional Profiling
- Where
- Luxembourg
- Volunteers
- 188 people
- Sponsor
- Luxembourg Institute of Health
Primary Ciliary Dyskinesia, Cystic Fibrosis
Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children
The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.
- Trial name
- NCT04161313
- Testing
- Measurement of functional capacity, pulmonary function test, Functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Bowel Dysfunction, Dysmotility
Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children
The goal of this clinical trial is to learn if the new non-invasive device (Body Surface Colonic Mapping) works to accurately assess colonic movement and function in children.The main questions it aims to answer are: Are Body…
- Conditions
- Bowel Dysfunction, Dysmotility, Hirschsprung Disease, Anorectal Malformations
- Trial name
- NCT07789782
- Testing
- Body Surface Colonic Mapping
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Murdoch Childrens Research Institute
Irritable Bowel Syndrome
Long-term Sacral Nerve Stimulation for Irritable Bowel Syndrome.
A recent randomised, controlled, crossover study has shown that sacral nerve stimulation (SNS) significantly reduces symptoms and improves quality of life of highly selected patients with irritable bowel syndrome (IBS).
- Trial name
- NCT02294760
- Testing
- Subsensory, OFF
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- University of Aarhus
Functional Dyspepsia, Chronic Atrophic Gastritis (CAG)
Correlation Study of Atrophic Gastritis and Dyspepsia Symptoms
Background: Dyspepsia is a common gastrointestinal complaint globally, affecting approximately 21.8% of the population. Among patients presenting with dyspeptic symptoms, over 80% are diagnosed with functional dyspepsia (FD)…
- Trial name
- NCT07250308
- Where
- China
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
Fructose Breath-testing in Irritable Bowel Syndrome (IBS)
Background: Breath testing for food intolerances is becoming routine in patients with functional gastrointestinal disorders (FGID).
- Trial name
- NCT02614313
- Testing
- Open breath test with fructose, Blinded breath test with fructose
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brain-Gut Research Group
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non Celiac Wheat Sensitivity
Liver Steatosis and Fibrosis in Non-Celiac Wheat Sensitivity Patients: a Prospective Study
Hypothesizing an intestinal barrier impairment as a common pathophysiological substrate of both Non Celiac Wheat Sensitivity (NCWS) and Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD), in a retrospective cohort…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non Celiac Wheat Sensitivity, Irritable Bowel Syndrome, Functional Dyspepsia
- Trial name
- NCT07750535
- Testing
- Prevalence and severity of liver steatosis and fibrosis,
- Where
- 2 sites in Italy
- Volunteers
- 250 people
- Sponsor
- University of Palermo
Infantile Colic, Gastroesophageal Reflux (GER)
BioAmicus Complete for Functional Gastrointestinal Symptoms in Infants Aged 0 to 24 Months
Infants often experience functional gastrointestinal symptoms (e.g., colic, excessive gas, regurgitation, constipation, or loose stools) that distress families and may reflect an imbalance of the gut microbiome.
- Conditions
- Infantile Colic, Gastroesophageal Reflux (GER), Functional Constipation, Functional Diarrhea
- Trial name
- CTBE2503 (NCT07148583)
- Testing
- BioAmicus Complete, Usual Care (No Probiotic)
- Where
- Vietnam
- Volunteers
- 110 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
Dyspepsia
Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia
This is a multi-Asian-centre randomised controlled trial of Rebamipide alone vs Rebamipide with Esomeprazole in the treatment of adult patients with Functional Dyspepsia.
- Trial name
- NCT02134405
- Testing
- Rebamipide, Esomeprazole
- Where
- Malaysia
- Volunteers
- 200 people
- Sponsor
- University of Malaya
Irritable Bowel Syndrome
Is There Any Correlation Between Plasmatic Zonulin and Expression of Intestinal Tight Junction Proteins in IBS Patients?
Increased intestinal permeability is one of the main pathophysiological mechanisms involved in irritable bowel syndrome. The expression of some intestinal tight junction proteins is decreased mostly in IBS-diarrhoea patients.
- Trial name
- BISII (NCT02877654)
- Testing
- colonoscopy with biopsies in the left colon to assess intestinal permeability
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Rouen
Irritable Bowel Syndrome-IBS
Effect of Different Dietary Therapies on Intestinal Barrier Integrity in Patients With Irritable Bowel Syndrome
This study aims to evaluate the effects of different dietary treatments on intestinal integrity in female subjects aged 19-50 years previously diagnosed with constipation-predominant irritable bowel syndrome (IBS).
- Trial name
- NCT06421922
- Testing
- Group 1 received a regular constipation diet, Group 2 received a constipation diet rich in soluble fiber, Group 3 received a constipation diet supplemented with probiotic yogurt.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gulhane Training and Research Hospital
Cystic Fibrosis, Homozygous F508del Mutation
Validation of Respiratory Epithelial Functional Assessment to Predict Clinical Efficacy of Orkambi®.
The purpose of the study is to investigate whether the correction of CFTR function by Lumacaftor/Ivacaftor in a patient-derived primary nasal cell model is a surrogate biomarker for respiratory improvement in Orkambi® treated…
- Trial name
- PREDICT-CF (NCT03894657)
- Testing
- Nasal brushing, Sputum sample, blood sample
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes Mellitus
Effect of 4 Weeks of Oral Probiotic Desulfovibrio Piger Supplementation on Immunological and Metabolic Parameters in Individuals With Longstanding Type 1 Diabetes
The goal is to establish the effect of oral probiotic Desulfovibrio piger (D. piger) supplementation on immunological and metabolic parameters in individuals with longstanding type 1 diabetes with residual beta cell function.
- Trial name
- PROSPER (NCT07585994)
- Testing
- Probiotic dietary supplement
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Thyroidectomy, Voice Alteration
Impact of Total Thyroidectomy on Voice and Swallowing
Purpose of this study is to evaluate the outcome of total thyroidectomy on vocal and swallowing function.
- Conditions
- Thyroidectomy, Voice Alteration, Swallowing Alteration
- Trial name
- NCT01607242
- Testing
- Endoscopy of larynx, Voice Handicap Index, Swallowing Assesment
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Thessaly
Lupus Erythematosus, Systemic, Gastrointestinal Microbiome
Assessment of Cognitive Function and Gut Microbiota Analysis in Real World Patients With Lupus Cerebrovascular Disease
Based on clinical manifestations, laboratory data and intestinal microflora detection, the cognitive function characteristics of patients with systemic lupus erythematosus and cerebrovascular disease and its relationship with…
- Trial name
- NCT05636670
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Irritable Bowel Syndrome
Efficacy of Physiotherapy Techniques on Irritable Bowel Syndrome (IBS). Pilot Study.
Introduction and State of Question Irritable Bowel Syndrome can be classified as a functional digestive disorder characterized by abdominal pain, bloating, and changes in the frequency and consistency of bowel movements.
- Trial name
- IBS (NCT04486469)
- Testing
- Physical Therapy Group
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- IBS Group, Alcalde
Irritable Bowel Syndrome
Patient Attributes for Optimal Treatment Outcome in Irritable Bowel Syndrome.
The purpose of this study is to determine if any specific patient characteristics lead to improved outcome of IBS treatment, when conventional treatment as well as Cognitive Behavioral Therapy is used in combination.
- Trial name
- IBS (NCT01297556)
- Testing
- Cognitive Behavior Therapy(CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Michigan Gastroenterology Institute