Clinical trials: Functional Disorders
Paralytic Ileus
The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section
Following all abdominal surgery, paralytic ileus commonly develops. Surgeons have traditionally withheld postoperative oral intake until the return of bowel function to prevent related complications.
- Trial name
- GUM01 (NCT01131416)
- Testing
- Gum chewing
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Hypoparathyroidism, Pseudo Hypoparathyroidism
QoL and Cognitive Function in Patients With Hypoparathyroidism
Hypoparathyroidism (HypoPT) is a disease with inadequate production of parathyroid hormone (PTH) from the parathyroid glands leading to hypocalcemia.
- Trial name
- MR-hypoPT (NCT04569604)
- Testing
- MRI scans, Neuro cognitive tests, Questionnaires on Quality of Life
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Graves Disease, Minimally Invasive Treatment
A Prospective Evaluation of Microwave Ablation (MWA) in the Treatment of Relapsed Graves' Disease
Graves' disease is the most common cause of hyperthyroidism, with conventional treatment options being anti-thyroid drugs (ATD), radioiodine (RAI) and surgery. For ATD, it has been the first-line treatment over decades.
- Conditions
- Graves Disease, Minimally Invasive Treatment, Ablation Treatment
- Trial name
- NCT06506149
- Testing
- Microwave ablation(MWA) device
- Where
- Hong Kong
- Volunteers
- 25 people
- Sponsor
- The University of Hong Kong
Diabete Type 2, Obesity
Ph 2a Study of HU6 on Energy Metabolism, Muscle and Liver Substrate Metabolism, and Mitochondrial Function in Subjects Who Are Overweight or Obese With Type 2 Diabetes
This is a randomized, double-blind, placebo-controlled parallel group study of HU6 and placebo in subjects who are overweight or obese with T2D. The study will be conducted in 4 stages.
- Trial name
- NCT06104358
- Testing
- HU6
- Where
- United States
- Sponsor
- Rivus Pharmaceuticals, Inc.
Unilateral and Bilateral Cerebral Palsy
Quality of Life in Children With Cerebral Palsy
Cerebral Palsy (CP) is an umbrella term that defines a group of permanent disorders of movement and posture, happening during the developing foetal or infant brain.
- Trial name
- NCT06288958
- Testing
- Quality of Life and social participation in Italian children with CP
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Fondazione Stella Maris
Irritable Bowel Syndrome (IBS)
Confocal Endomicroscopy Utility (p-CLE) in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders. It has prevalence in general population of 5-20% and is more common in women and young adults.
- Trial name
- NCT02651532
- Testing
- Confocal Laser Endomicroscopy
- Where
- Ecuador
- Volunteers
- 74 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Somatic Symptom and Related Disorders, Somatic Symptom Disorder
Telehealth Group-based Emotional Awareness and Expression Therapy for Patients With Persistent Physical Symptoms: A Pilot Study
Delivering Emotional Awareness and Expression Therapy (EAET) through digital or telehealth platforms in a group format offers several key advantages.
- Conditions
- Somatic Symptom and Related Disorders, Somatic Symptom Disorder, Functional Somatic Disorder, Functional Somatic Syndrome
- Trial name
- NCT06631963
- Testing
- Emotional Awareness and Expression Therapy
- Where
- Sweden
- Sponsor
- Daniel Maroti
Preterm Infant
Executive Functions and Preterm Children in 3 to 4 Year Old
Preterm children have a high risk for neurodevelopmental impairments. The impact on motor functions and neurosensory functions is demonstrated but the incidenceof executive functions is not described for preterm infants.
- Trial name
- NCT03700463
- Testing
- BRIEF parental survey
- Where
- France
- Volunteers
- 356 people
- Sponsor
- Nantes University Hospital
Stroke
Robot-assisted Hand Rehabilitation for Patients With Stroke
Robotic therapy can deliver larger amounts of upper extremity movement practice for stroke rehabilitation. Although the treatment effects were supported in studies, there are still limitations in clinical intervention.
- Trial name
- NCT03392493
- Testing
- Robot-assisted hand rehabilitation, Standard treatment
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Breast Cancer
C11 AMT Positron Emission Tomography (PET) Imaging in Patients With Metastatic Invasive Breast Cancer
The purpose of this research project is to create images of where and how the amino acid (the building blocks of proteins)Tryptophan is processed in normal and abnormal tissue in the patient's body.
- Trial name
- NCT01302821
- Testing
- Adenovirus-p53 transduced dendritic cell vaccine, 1-methyl-D-tryptophan, Carbon C 11 alpha-methyltryptophan
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Metabolic Dysfunction-Associated Steatotic Liver Disease
The Impact of Nutrition Education and Rice Bran Supplementation on Metabolic Dysfunction-associated Steatotic Liver Disease
This study aims to evaluate the effects of nutrition education with or without rice bran supplementation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
- Trial name
- NCT07524621
- Testing
- Nutrition Education, Rice Bran
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- Shih Chien University
Non-Alcoholic Fatty Liver Disease
Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD
This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota…
- Trial name
- CARDIO-LIVER (NCT06704321)
- Testing
- TOTUM-448
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Hernia, Inguinal, Convalescence
Objective Measure of Recovery After Outpatient Surgery
This is a study using wearable monitoring devices, patient activity and sleep patterns to monitor pre and post operative following outpatient inguinal hernia surgery to determine when these parameters return to baseline.
- Trial name
- NCT02616406
- Testing
- GENEactiv
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Cognitive Impairment (CI)
Post-operative Functional Disability in Unrecognized Cognitive Impairment (POF) Study
This is a prospective multicenter cohort study, which will determine the prevalence of preoperative cognitive impairment (CI) using the Modified Telephone Interview for Cognitive Status (TICS-M), Eight-items interview to…
- Trial name
- NCT04850833
- Where
- 2 sites in Canada
- Volunteers
- 390 people
- Sponsor
- University Health Network, Toronto
Diabetes, Hypertension
Renal and Hormonal Effects of Pioglitazone
This study examines the effects of pioglitazone on renal sodium handling in subjects prone to insulin resistance, i.e. diabetic and/or hypertensive subjects.
- Trial name
- NCT01090752
- Testing
- Pioglitazone, Metformin
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University Hospital, Geneva
Cardiovascular Benefits of Zingiber Officinale Roscoe in Patients With Type 2 Diabetes Mellitus Before and After 6 Weeks of add-on Therapy
The Cardiovascular Effects of Ginger (Zingiber Officinale) in Patients With Type II Diabetes Mellitus
The aim of the study was the evaluation of cardiovascular benefits of Zingiber officinale Roscoe in patients with type 2 diabetes mellitus before and after 6 weeks of add-on therapy.
- Trial name
- GINOFF1 (NCT04222738)
- Testing
- GINOFF1
- Where
- Cameroon
- Volunteers
- 21 people
- Sponsor
- Yaounde Central Hospital
Cognition Disorder, Functional Brain Imaging
fMRI and NIRS Imaging for Traumatic Brain Injury
Background: The amount of blood flowing in brain areas goes up when those areas are being used for activities, such as movement or seeing.
- Trial name
- NCT01668758
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Schizophrenia, Functional Magnetic Resonance Imaging
Effect of Intermittent Theta Burst Stimulation (iTBS) for Alleviating Symptoms of Schizophrenia Patients
To investigate the treatment effect of intermittent theta-burst transcranial magnetic stimulation on symptomatic relief of schizophrenia patients, and the underlying neural mechanism by functional MRI and the resting…
- Conditions
- Schizophrenia, Functional Magnetic Resonance Imaging, Transcranial Magnetic Stimulation
- Trial name
- NCT03868358
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- WANG KAI
COPD - Chronic Obstructive Pulmonary Disease, Healty Controls
Hemodynamic Responses and Brain Activity During Dual Tasks in COPD Patients Versus Healthy Individuals
Abstract Cognitive dysfunction is joint in patients with chronic obstructive pulmonary disease (COPD). In particular, there are effects in tasks that require attention, executive functions, and working memory related to the…
- Trial name
- NCT06974448
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cystocele
Detrusor Underactivity and Bladder Outlet Obstruction in Women With Cystocele
Women with cystocele may be associated with detrusor underactivity (DU) or bladder outlet obstruction (BOO). However, the impact of cystocele repair on the rates of DU and BOO remained obscure.
- Trial name
- NCT04184128
- Testing
- Urodynamic study
- Where
- Taiwan
- Volunteers
- 623 people
- Sponsor
- National Taiwan University Hospital