Clinical trials: Functional Disturbance
Cognitive Impairment
Walking Interventions, Cognitive Remediation and Mild Cognitive Impairment
The purpose of this study is to determine the effects of a coordinated intervention of cognitive remediation training (CRT) and walking intervention on cognition and gait in the elderly.
- Trial name
- WalkCog-MCI (NCT01801943)
- Testing
- Cognitive Remediation Therapy Group, Walking Intervention (WI) Group, Combination Group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Endothelial Dysfunction
Centella Asiatica in Older Adults
The purpose of this study is to determine the effects of a dietary supplement containing centella asiatica on on vascular endothelial function in older adults.
- Trial name
- NCT06472791
- Testing
- Centella Asiatica
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Anorexia Nervosa, Bulimia Nervosa
PROspective Longitudinal All-comer Inclusion Study in Eating Disorders
The PROLED study is a prospective and longitudinal study of patients with Eating Disorders. Annual interviews and collection of biological samples are done, as well as during changes in disease course e.g. during hospitalization.
- Conditions
- Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, Eating Disorder NOS
- Trial name
- PROLED (NCT03224091)
- Where
- Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD
This study will test a study drug called ALN-PNP with and without another drug that is used for controlling blood sugar, appetite, and weight (for example, tirzepatide), to see if it can help treat MASLD, also known as fatty…
- Trial name
- NCT07527910
- Testing
- ALN-PNP, Tirzepatide
- Where
- 9 sites in United States
- Volunteers
- 204 people
- Sponsor
- Regeneron Pharmaceuticals
Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction
Biological Effects of Hemoadsorption in Septic Shock
Septic shock is the most severe form of sepsis and continues to carry an in-hospital mortality of between 30% and 50% despite advances in compliance with the Surviving Sepsis Campaign care bundles.
- Conditions
- Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction, Sepsis, Hemoperfusion
- Trial name
- Bio-HA380 (NCT07715110)
- Testing
- Hemoadsorption cartridge
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Miguel Sanchez Garcia
Respiratory Failure
Gas Exchange Derangement Physiopathology in Critically Ill Patients With COVID-19
The study was designed to understand the pathophysiology of gas exchange derangement in critically ill patients with COVID-19. Specifically we will evaluate the effect of 3 different levels of positive end-expiratory pressure…
- Trial name
- NCT05132933
- Testing
- PEEP trial - Electrical Impedance Tomography
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Policlinico Hospital
Bowel Dysfunction
Gastrointestinal Activation Post-elective CS (Cesarean Section) :A Comparison of Paula Method to Standard Care
Women generally report discomfort and a delay in GI motility after CS. The Paula method, circular exercises of ring muscles has been shown to increase GI motility. This method had not been studied in women post CS.
- Trial name
- NCT03761147
- Testing
- Paula exercises
- Where
- Israel
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction
RaGuS Trial by Postoperative Patients
Vasoplegic syndrome is characterized clinically by reduced systemic vascular resistance and normal or increased cardiac output. It is principally observed in cardiovascular and orthopedic interventions and is characterized by a…
- Conditions
- Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction, Orthostatic Hypotension
- Trial name
- RaGuS (NCT04440085)
- Testing
- Midodrine Hydrochloride
- Volunteers
- 50 people
- Sponsor
- Bürgerspital Solothurn
Delirium, Dementia
Speed of Processing Training for Cognitive Deficits After Delirium in Older Adults
In this proposal, we will examine processing speed training (PST) as a potential intervention to reduce the risk of developing long-term cognitive impairment after a delirium episode.
- Trial name
- NCT03342989
- Testing
- Speed of Processing Training, Internet-Based Contact Control
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Alabama at Birmingham
Cognitive Impairment, Dementia
Anticipating Decline and Providing Therapy
This pilot feasibility study will be a randomized control trial of usual care following Intensive Care Unit (ICU) discharge compared to the Anticipating Decline and Providing Therapy (ADAPT) screening and support intervention.
- Conditions
- Cognitive Impairment, Dementia, Post ICU Syndrome, Critical Illness
- Trial name
- ADAPT (NCT06182995)
- Testing
- Usual Care post-Intensive Care Unit (ICU), Anticipating Decline and Providing Therapy (ADAPT)
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Wake Forest University Health Sciences
Fontan Physiology Patients With PB or PLE, Fontan Physiology Patients Without PB or PLE
Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology
The investigators are studying what causes Plastic Bronchitis and Protein Losing Enteropathy. The investigators think that these problems are from too much of two small proteins called Vasoactive Intestinal Peptide (VIP) and…
- Trial name
- NCT01563757
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Heart Failure, Cognitive Impairment
Mind Your Heart-II
This projects studies the role of mindfulness training (MT) to improve self-care among patients with heart failure and cognitive impairment.
- Trial name
- MYH-II (NCT05431192)
- Testing
- Mindfulness Training + Enhanced Usual Care, Enhanced Usual Care
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- The Miriam Hospital
Mild Neurocognitive Disorder
Deep rTMS for Mild Neurocognitive Disorder in Older Adults
This study aims to: (1) assess the feasibility and tolerability of three deep transcranial magnetic stimulation (dTMS) coils H1, H4, and H7 in older adults with mild neurocognitive disorder (mild NCD); and (2) evaluate changes in…
- Trial name
- Deep MIND (NCT07038798)
- Testing
- Brainsway H1-Coil Deep TMS System, Brainsway H4-Coil Deep TMS System, Brainsway H7-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Parkinson Disease
Deep Brain Stimulation (DBS) of the Pedunculopontine Nucleus (PPN)
This is a mechanistic study to determine the differential effects of the dopaminergic and cholinergic systems on attention, gait, and balance.
- Trial name
- PPNGB01 (NCT04605263)
- Testing
- STN-PPN DBS Surgery, Deep Brain Stimulation Surgery (DBS)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Hypertension With Renal Dysfunction
Safety and Tolerability and Efficacy of LCZ696 in Japanese Hypertensive Patients With Renal Dysfunction
This study assessed the safety, tolerability, and efficacy of LCZ696 in hypertensive patients with renal dysfunction.
- Trial name
- NCT01593787
- Testing
- LCZ696
- Where
- 13 sites in Japan
- Volunteers
- 32 people
- Sponsor
- Novartis Pharmaceuticals
Female Sexual Dysfunction (FSD)
Impact of Tibial Nerve Stimulation on Lumbopelvic Mechanics and Sexual Function in Females With Sexual Dysfunctions
This study will be conducted to examine the effects of Transcutaneous Tibial Nerve Stimulation (TTNS) on lumbopelvic mechanics and sexual function in females with sexual dysfunctions and low back pain
- Trial name
- NCT07764445
- Testing
- Pelvic floor exercise, transcutaneous tibial nerve stimulation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Sexual Dysfunction, Psychological
Zestra in Women With Mixed Sexual Dysfunction
The objective of this study is to evaluate the clinical efficacy and safety of Zestra(TM) in women with acquired mixed desire/interest/arousal/orgasm disorders under conditions of home usage.
- Trial name
- NCT00118495
- Testing
- Non-prescription Zestra(TM): patented formulation
- Where
- 13 sites in United States
- Volunteers
- 200 people
- Sponsor
- QualiLife Pharmaceuticals
Rectal Cancer, Rectosigmoid Cancer
Physical Activity in Rectal Cancer Survivors
The goal of this clinical trial is to test a telehealth-based personalized physical activity intervention in adult patients diagnosed with Stage I-III rectal cancer.
- Trial name
- NCT06435975
- Testing
- Physical Activity, Survey, Telehealth Lifestyle Coaching
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Mild Cognitive Impairment, Cognitive Decline
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
- Trial name
- NCT03954899
- Testing
- melatonin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Natalie Denburg
Sexual Dysfunction, Sexual Abstinence
Using of Testes' Shocker in Improving Sexual Activity
Using of testes' shocker in treating the sexual dysfunction.
- Conditions
- Sexual Dysfunction, Sexual Abstinence, Sexual Desire Disorder, Erectile Dysfunction
- Trial name
- NCT04662398
- Testing
- JT Device
- Where
- Iraq
- Volunteers
- 77 people
- Sponsor
- University of Baghdad