Clinical trials: Functional Dyspepsia
Dyspepsia, Functional Gastrointestinal Disorders
Traditional Dietary Advice Versus Reassurance-alone in Postprandial Functional Dyspepsia
Functional dyspepsia is common, affecting 7.2% of the global population, and associated with substantial health impairment. Almost 80% of patients with functional dyspepsia report meal-related symptoms and are classified as…
- Trial name
- NCT05718960
- Testing
- Reassurance-alone, Traditional dietary advice
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Therapeutic Mechanism of Antidepressants for Refractory FD
MRI Study of Antidepressants in the Treatment of Refractory Functional Dyspepsia
In this study, diffusion tensor imaging（DTI）technique was used to evaluate the brain microstructures and connective white matter microstructures in patients with refractory FD, resting fMRI was used to evaluate the functional…
- Trial name
- NCT03973567
- Testing
- selective serotonin reuptake inhibitor (SSRI) or serotonin noradrenaline reuptake inhibitor (SNRI) antidepressants, conventional therapy
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Functional Dyspepsia, Probiotics
Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia
Objective: This study aims to evaluate the effectiveness of Bacillus coagulans in improving anxiety and depression in patients diagnosed with functional dyspepsia according to the Rome IV criteria.
- Conditions
- Functional Dyspepsia, Probiotics, Depression, Anxiety
- Trial name
- NCT07187492
- Testing
- Bacillus coagulans
- Where
- China
- Volunteers
- 181 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Functional Dyspepsia
Does Visceral Manipulation Works in Treating Functional Dyspepsia?
The goal of this study is to determine if Visceral Manipulation (VM) is effective in treating Functional Dyspepsia in addition to drug therapy. Null hypothesis is that VM does not influence FD symptoms.
- Trial name
- NCT01021475
- Testing
- Visceral Manipulation, PPIs and/or Domperidone
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- International College of Osteopathic Medicine
Functional Dyspepsia
Association Between Luminal Bile Salt Content and Duodenal Mucosal Integrity in Functional Dyspepsia
Functional dyspepsia (FD) is an extremely common disorder of gastrointestinal function. Recently, impaired duodenal mucosal integrity was reported as a potential pathophysiological mechanism in FD.
- Trial name
- NCT03003234
- Testing
- Duodenogastroscopy, Duodenal aspiration catheter, Nutri drink
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Functional Dyspepsia
The Efficacy and Safety of Qizhiweitong Granule on Patients With Functional Dyspepsia in a Multi-center Clinical Study
The study aims to verify the efficacy and safety of Qizhiweitong granule on Chinese patients with functional dyspepsia diagnosed by the Rome III criteria.
- Trial name
- NCT02460601
- Testing
- Qizhiweitong granule
- Volunteers
- 400 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Functional Dyspepsia
The Role of Intestinal Flora in the Pathogenesis of FD and the Intervention of Xiangsha Liujunzi
Functional dyspepsia (FD) is a common digestive system disease in clinic. Although it has not reached the level of life-threatening, it seriously affects the quality of life of patients.
- Trial name
- NCT04449887
- Testing
- Xiangsha Liujunzi granules
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Functional Dysphonia
Artemisia and Green Tea Extracts for Gastric Mucosal Health
This clinical trial aims to determine whether Artemisia and green tea extracts promote gastric mucosal health in adults with functional dyspepsia and to assess its safety.
- Trial name
- NCT06628804
- Testing
- Artemisia and green tea extracts
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Functional Dyspepsia
Mechanisms of Electroacupuncture for Functional Dyspepsia Based on "Enterotypes" and Metabolomics
The goal of this clinical trial is to explore the clinical efficacy and possible mechanisms of electroacupuncture treatment for functional dyspepsia (FD).
- Trial name
- NCT05920395
- Testing
- Electro-acupuncture
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Wuhan Central Hospital
Irritable Bowel Syndrome (IBS), Functional Dyspepsia
Interactive Effects of Early-Life Stress, Diet, and Metabolism on Gastrointestinal Dysfunction With Neuropsychiatric Symptoms
The goal of this observational case-control study is to learn how stressful experiences, dietary habits, and blood nutrient levels are associated with gastrointestinal symptoms and symptoms of depression and anxiety in adults…
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Inflammatory Bowel Disease (IBD), Gastroparesis
- Trial name
- NCT07852819
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Dyspepsia
Serotonin Effect in Functional Dyspepsia
The purpose of this study is to investigate whether Efexor (venlafaxine) is effective in the treatment of functional dyspepsia.
- Trial name
- NCT00115362
- Testing
- venlafaxine
- Where
- 6 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- Radboud University Medical Center
Functional Dyspepsia
Neuro-immune Interactions and PPI
Prospective interventional study on duodenal neuro-immune interactions in healthy volunteers and functional dyspepsia patients and the effects of PPI
- Trial name
- NCT04713969
- Testing
- Pantoprazole 40mg
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Functional Dyspepsia
Gabapentin in Functional Dyspepsia Refractory to Proton Pump Inhibition
The purpose of this study is to evaluate the effectiveness of gabapentin on symptom control in patients with defined functional dyspepsia refractory to conventional proton pump inhibitor therapy and to compare these effects to…
- Trial name
- NCT01052896
- Testing
- Gabapentin
- Where
- 2 sites in United States
- Sponsor
- 59th Medical Wing
Dyspepsia and Other Specified Disorders of Function of Stomach
PEA in Functional Dyspepsia
The goal of this placebo controlled randomized double blind interventional study is to assess the effect of palmitoylethanolamide supplementation in patients with functional dyspepsia The main questions it aims to answer are: The…
- Trial name
- NCT05877781
- Testing
- Palmitoylethanolamide
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Functional Gastrointestinal Disorders
Study in Patients Suffering From Heartburn and Backward Flow of Stomach Liquid Into the Esophagus
In this study researchers want to learn more about the effectiveness of Iberogast® in patients with irritable stomach and concomitant chronic or recurrent heartburn and backward flow of stomach liquid into the esophagus.
- Trial name
- NCT04059900
- Testing
- STW5 (Iberogast®, BAY98-7411)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Bayer
Functional Dyspepsia, Anorexia Nervosa
Identifying Multidimensional Signatures of Gastric Interoception in Functional Dyspepsia
This study is being conducted to investigate gut-brain communication in individuals with functional dyspepsia and anorexia nervosa.
- Trial name
- IMAGINE (NCT07772167)
- Testing
- Functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Dyspepsia and Other Specified Disorders of Function of Stomach
Holy Basil in The Treatment of Dyspepsia
The goal of this clinical trial is to evaluate whether holy basil extract can reduce gastric inflammation and improve symptoms in adult patients with dyspepsia.
- Trial name
- NCT07175272
- Testing
- Holy basil extract
- Where
- Thailand
- Volunteers
- 27 people
- Sponsor
- Mahidol University
Dyspepsia
Gastric Activity and Gastrointestinal Peptides in Patients With Functional Dyspepsia
Rome III criteria defined functional dyspepsia (FD) as the presence of symptoms from the gastroduodenal region in the absence of any organic, systemic or metabolic disease that is likely to explain the symptoms.
- Trial name
- DYSMOT-RIII (NCT02113527)
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Functional Dyspepsia
Functional Dyspepsia: Validation of the Leuven Postprandial Distress Scale (LPDS) in a Placebo-controlled Trial
No instrument is available for the assessment of the symptoms in patients suffering from functional dyspepsia - postprandial distress syndrome patients - PDS. Indeed PDS is an unmet clinical need in drug development.
- Trial name
- NCT04464369
- Testing
- itopride
- Where
- Belgium
- Volunteers
- 105 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Functional Dyspepsia
Functional Dyspepsia Microbiome Study
Recurrent abdominal pain has long been acknowledged to be the most common chronic pain entities in children. The purpose of this study is to describe the microbiome in children with FD and to explore relationships between the…
- Trial name
- NCT02340312
- Testing
- EGD, Collection of Stool Specimens
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City