Clinical trials: Functional Endoscopic Sinus Surgeries
Sinusitis, Chronic Sinusitis
Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus Surgery
This study will compare the incidence of post-op infection after sinus surgery using conventional post-op oral antibiotics to the incidence of infection after sinus surgery when a bio-resorbable antibiotic soaked nasal sponge is…
- Trial name
- NCT00705354
- Testing
- Bacitracin, Nasopore sponge soaked with saline
- Where
- United States
- Sponsor
- Lahey Clinic
Sinusitis
15-Degree Tilt, Head Up, Feet Down Body Position for Sinus Surgery Patients
Functional Endoscopic Sinus Surgery (FESS) is normally performed in our centre in a 0-degree supine position, with the patient laying flat.
- Trial name
- RTP (NCT01442740)
- Testing
- Reverse Trendelenburg Position
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- St. Paul's Hospital, Canada
Sinus Surgery
Opioid Sparing Effect of Sphenopalatine Ganglion Block in Functional Endoscopic Sinus Surgery: a Randomized Controlled Clinical Trial.
Functional endoscopic sinus surgery (FESS) is widely recognized as a safe and preferred treatment option for various conditions, particularly nasal polyps and rhinosinusitis .
- Trial name
- NCT06752525
- Testing
- Bupivacaine, Magnesium Sulphate 500 mg
- Volunteers
- 60 people
- Sponsor
- Assiut University
Chronic Rhinosinusitis, Enhanced Recovery After Surgery
Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery
Functional endoscopic sinus surgery (FESS) is one of the effective modalities for the treatment of Functional endoscopic sinus surgery (FESS) is one of the effective ways to treat chronic sinusitis, which has the advantages of…
- Trial name
- NCT06920576
- Testing
- Esketamine, Magnesium sulfate, Saline
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Second People's Hospital of Huai'an
Rhinosinusitis Chronic, Bleeding
This Study Aims to Assess the Impact of 50°C Saline Irrigation on the Overall Intraoperative Blood Loss and Surgical Visualization During Endoscopic Sinus Surgery for Rhinosinusitis.
Objectives: Intraoperative bleeding during endoscopic sinus surgery for severe rhinosinusitis may significantly compromise the surgical field.
- Trial name
- NCT07627789
- Testing
- Hot saline irrigation, Room-temperature saline irrigation
- Where
- Poland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Military Institute of Aviation Medicine
Sinus Infection Chronic
Propofol Versus Sevoflurane During FESS
Good surgical conditions are crucial for an optimal surgery result and safe procedure. Minimal blood loss in the surgical field is one of the most important conditions to maintain a good visualization, especially in surgeries…
- Trial name
- NCT04619160
- Testing
- Propofol, Sevoflurane
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Nasal Sinus; Inflammation, Opioid Abuse
Pain Management Following Sinus Surgery
This Study evaluates the effect of adding Non-steroidal anti-inflammatories (NSAIDs) to the post-operative pain management of sinus surgery patients and wether or not this addition reduces or eliminates the need for narcotic pain…
- Conditions
- Nasal Sinus; Inflammation, Opioid Abuse, Pain, Postoperative
- Trial name
- NCT03822962
- Testing
- Ibuprofen 600Mg Tablet, Standard Regimen | Tylenol
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Asthma, Nasal Polyps
ATP Project (Asthma afTer Polypectomy)
Inflammation of the nasal and bronchial mucosa characterizing rhinitis and asthma are probably manifestations of the same disease. Multiple functional observations, pathogenic and clinical support that assertion.
- Trial name
- ATP (NCT02427503)
- Testing
- Asthma with NP and require surgery
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Functional Endoscopic Sinus Surgery
Opioid Free Anesthesia in ENT Surgery
Opioid Free Anesthesia (OFA) - which has been applied mainly in bariatric surgery - has begun to receive more and more attention and to obtain fanatical supporters versus conventional anesthesia.
- Trial name
- NCT04105946
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Thessaly
Chronic Rhinosinusitis, Intraoperative Bleeding
Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy
Functional endoscopic sinus surgery (FESS), or sinusoscopy, is a standard surgical procedure used to treat chronic rhinosinusitis and other conditions of the nasal sinuses.
- Conditions
- Chronic Rhinosinusitis, Intraoperative Bleeding, Blood Loss, Surgical
- Trial name
- NCT07866274
- Testing
- Ascorbic acid
- Volunteers
- 78 people
- Sponsor
- Assiut University
Intraoperative Bleeding
Lidocaine in ERAS for FESS
Functional endoscopic sinus surgery (FESS) is a commonly performed procedure. It is known that bleeding during FESS can affect directly to the visibility of safe landmarks and surgical outcomes.
- Trial name
- NCT03047070
- Testing
- Lidocaine, Normal saline
- Where
- 2 sites in Egypt
- Volunteers
- 43 people
- Sponsor
- Assiut University
Chronic Rhinosinusitis
Microcurrent Device (TIVIC Health)
The purpose of this study is to investigate whether daily use of a microcurrent neuromodulation device, which applies a small current of electricity to the forehead and maxillary region, will decrease the pain experienced by…
- Trial name
- NCT05198518
- Testing
- Microcurrent TENS device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Sinusitis Chronic
GLS-1200 Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery
This clinical trial will evaluate the safety, tolerability and effectiveness of GLS-1200 nasal spray in addition to the standard of care after endoscopic sinus surgery in people with chronic sinusitis.
- Trial name
- NCT04060316
- Testing
- GLS-1200
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- GeneOne Life Science, Inc.
Chronic Rhinosinusitis, Postoperative Care
Efficacy and Safety of Xylitol Nasal Irrigation After Functional Endoscopic Sinus Surgery
Investigators tried to evaluate the efficacy and safety of xylitol nasal irrigation as an adjuvant therapy after FESS, particularly the influence of nasal irrigation on Eustachian tube function.
- Trial name
- NCT06108921
- Testing
- Xylitol Powder, Salt Powder
- Where
- Taiwan
- Volunteers
- 79 people
- Sponsor
- Taichung Veterans General Hospital
Functional Endoscopic Sinus Surgery, Premedication
Intranasal Versus Intravenous Dexmedetomidine for Hypotensive Anesthesia in FESS
Intranasal dexmedetomidine provided good pharmacokinetic profile. However, intravenous dexmedetomidine have been used in functional endoscopic sinus surgery for several outcomes, there is lack in studies that had compared the…
- Conditions
- Functional Endoscopic Sinus Surgery, Premedication, Analgesia
- Trial name
- NCT05604599
- Testing
- Intranasal dexmedetomidine, Intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Chronic Sinusitis
Clinical Evaluation of the Steroid-Eluting Sinexus Intranasal Splint When Used Following Functional Endoscopic Sinus Surgery (FESS) in Patients With Chronic Sinusitis
This study allows continued access to the Sinexus Intranasal Splint while a marketing application is being prepared. This study will generate additional performance, reimbursement and safety data for the steroid-eluting Sinexus…
- Trial name
- NCT00912405
- Testing
- Steroid-Eluting Sinexus Intranasal Splint
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Intersect ENT
Bleeding
Nasal Desmopressin Versus Oral Bisoprolol for Controlling Bleeding During Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is well established for treatment of chronic rhinosinusitis and nasal polyps. Masking of the surgical field can lead to severe complication as tissue injury, increase post-operative…
- Trial name
- NCT05430048
- Testing
- nasal Desmopressin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Zagazig University
Endoscopic Sinus Surgery
The Effect of Dexmedetomidine, Melatonin and Pregabalin
Various drugs have been used for the purpose: nitroglycerine, sodium nitroprusside, propofol, beta blockers, calcium channel blockers, higher concentrations of inhalational anesthetics etc.
- Trial name
- NCT05829148
- Testing
- Dexmedetomidine, Melatonin, Pregabalin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Egymedicalpedia
Chronic Sinusitis
Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery
The purpose of this study is to assess the use of IV acetaminophen (Ofirmev) as a and safe and efficacious agent in reducing post-operative pain; we hypothesize that its use will reduce post-operative pain when compared to a…
- Trial name
- IVAPAP (NCT01608308)
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- The University of Texas Health Science Center, Houston
Endoscopic Sinus Surgery
SPI-guided Analgesia During FESS for Intraoperative Blood Loss
The aim of this randomized trial is to assess the utility of Surgical Pleth Index (SPI) for monitoring pain perception intraoperatively and its influence on intraoperative blood loss, quality of surgical field using Boezaart…
- Trial name
- FESSSPI (NCT03417180)
- Testing
- Remifentanil, surgical pleth index
- Where
- 2 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Silesia