Clinical trials: Functional Endoscopic Sinus Surgery
Chronic Sinusitis
The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery
Sinus surgery is a common, day surgery procedure performed by general and subspecialty trained otolaryngologists. In most cases, this is a safe surgery with a low incidence of complications.
- Trial name
- NCT00671281
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- University of Calgary
Nasal Polyps
Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS
This study aimed to show the effect of sphinopalatine ganglion blockade on surgical field, hemodynamics and postoperative pain in FEES operation.
- Trial name
- NCT04996576
- Testing
- infrazygomatic approach sphinopalatine ganglion block, intranasal injection approach of sphinopalatine ganglion block
- Where
- 2 sites in Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Stress Response of Endotracheal Intubation and Surgical Field Clarity in FESS
Melatonin vs Metoprolol or Dexmedetomidine to Improve Surgical Field in FESS
This randomized controlled study at Zagazig University Hospitals will include 112 patients undergoing elective functional endoscopic sinus surgery, allocated into four groups (Melatonin, Metoprolol, Dexmedetomidine, Control).
- Trial name
- NCT07568873
- Testing
- Melatonin, Metoprolol (MET), Dexmedetomidine
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Zagazig University
Chronic Rhinosinusitis (CRS), Emergence Agitation
Trans-nasal Sphenopalatine Ganglion Block for Prevention of Emergence Agitation Following Functional Endoscopic Sinus Surgery
This randomized double-blind controlled trial aims to evaluate whether bilateral trans-nasal sphenopalatine ganglion block (SPGB) using bupivacaine reduces the incidence of emergence agitation following Functional Endoscopic…
- Trial name
- SPGB-EA (NCT07645521)
- Testing
- Bilateral Trans-nasal Sphenopalatine Ganglion Block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Sinusitis, Nasal Polyps
Comparison of Nasal Steroids After FESS in CRSwNP
The purpose of this study is to compare intranasal fluticasone spray with budesonide nasal saline rinses in both the upright and head forward positions in patients who have had functional endoscopic sinus surgery (FESS) for…
- Trial name
- NCT02194062
- Testing
- fluticasone nasal spray, Budesonide head upright, Budesonide head forward
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Yale University
Ultrasound, Brainlab Navigation
Ultrasound-Guided Versus Brainlab Navigation Sphenopalatine Ganglion Block in Functional Endoscopic Sinus Surgery
This study compares ultrasound-guided and Brainlab navigation sphenopalatine ganglion block (SPGB) in functional endoscopic sinus surgery (FESS).
- Conditions
- Ultrasound, Brainlab Navigation, Sphenopalatine Ganglion Block, Functional Endoscopic Sinus Surgery
- Trial name
- NCT06984913
- Testing
- Ultrasound-guided sphenopalatine ganglion block, Brainlab navigation sphenopalatine ganglion block, Low dose Brainlab navigation sphenopalatine ganglion block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Transanal Endoscopic Surgical Procedures, Residual Volume
The Effects of Pharyngeal Packing on the Postoperative Gastric Fluid Volume in Patients Undergoing Functional Endoscopic Nasal Surgery
In this study, the aim is to investigate the effects of Pharyngeal Packing on the perioperative gastric volume in patients undergoing FESS, by ultrasound assessment
- Conditions
- Transanal Endoscopic Surgical Procedures, Residual Volume, Gastric, Ultrasound
- Trial name
- NCT06957275
- Testing
- Nasal packing
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Kasr El Aini Hospital
Sore Throat
Dexmedetpmidine Versus Ketamine for Postoperative Sore Throat in Sinus Surgery
The aim of this randomized clinical trial is to evaluate the impact of dexmedetomidine versus ketamine soaked pharyngeal packing on postoperative sore throat in functional endoscopic sinus surgery (FESS).
- Trial name
- NCT04955158
- Testing
- Dexmedetomidine, Ketamine, saline 0.9%
- Where
- Egypt
- Volunteers
- 143 people
- Sponsor
- Assiut University
Nasal Polyps
Mometasone Furoate Nasal Spray for Treatment of Nasal Polyposis After Surgery (Study P03218)
This study was conducted to evaluate the effectiveness of mometasone nasal spray in preventing polyp relapse/symptom worsening in patients after surgical treatment of nasal polyps.
- Trial name
- NCT00731185
- Testing
- Mometasone Furoate Nasal Spray
- Volunteers
- 162 people
- Sponsor
- Organon and Co
Screening
Preoperative Nebulized Dexmedetomidine Versus Nebulized Magnesium Sulphate in Reducing Emergence Agitation in FESS
Emergence agitation after sinus surgery is a common postoperative complication characterized by confusion, disorientation, and potentially violent behavior as a patient wakes from general anesthesia.This study compare the effect…
- Trial name
- NCT07677917
- Testing
- Dexmedetomidine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Sinusitis
Hot Saline Irrigation Study
Many methods have been used to reduce bleeding during sinus surgery (FESS) in order to allow for the best surgical view and to reduce risk while in surgery.
- Trial name
- HSI (NCT01717274)
- Testing
- Hot saline irrigation
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Paul's Hospital, Canada
Preoperative, Phentolamine
Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery
The aim of this study is to evaluate the efficacy of intra-operative phentolamine vs intraoperative esmolol for hypotensive anesthesia in functional endoscopic sinus surgery.
- Conditions
- Preoperative, Phentolamine, Intraoperative, Esmolol
- Trial name
- NCT06620991
- Testing
- Phentolamine, Esmolol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Monitoring During Deliberate Hypotensive Anesthesia
Peripheral Perfusion Index (PPI) as Monitor During Deliberate Hypotensive Anesthesia
Hypotensive anesthesia is effective in reducing the intraoperative blood loss. The risk of hypoperfusion of vital organs continues to be a concern. An adequate monitoring of tissue perfusion and oxygenation is crucial issue.
- Trial name
- PPI (NCT03007355)
- Testing
- peripheral perfusion index measurement
- Volunteers
- 50 people
- Sponsor
- Cairo University
Condition of Patient 3 Years After FESS-operation
Long-term Control in Rhinosinusitis After Functional Endoscopic Sinus Surgery (FESS)
State-of-the-art documents like ARIA and european position paper on rhinosinusitis (EPOS) provide clinicians with evidence-based treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS) respectively (1)(2)…
- Trial name
- NCT01777425
- Where
- 2 sites in Belgium
- Volunteers
- 389 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Clinical Trial
Optimal Dosage of Melatonin for Preoperative Sedation in FESS
To determine the optimal dosage of Melatonin for preoperative sedation in patients undergoing FESS.
- Trial name
- FESS (NCT07550751)
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Enhanced Recovery, Functional Endoscopic Sinus Surgery
Lidocaine Infusion Versus Magnesium Infusion in Decreasing Fentanyl Requirements in Endoscopic Sinus Surgeries
Enhanced recovery after ear, nose and throat surgery is based on multimodal and multidisciplinary perioperative interventions to decrease postoperative pain.
- Conditions
- Enhanced Recovery, Functional Endoscopic Sinus Surgery, Lidocaine, Magnesium Sulphate
- Trial name
- NCT06966102
- Testing
- Lidocaine group, Magnesium group, Control group
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Cairo University
Emergence Agitation
Comparison of Effect of Dexmedetomidine and Midazolam on Emergence Agitation
Since the frequency of emergence agitation (EA) is relatively high in children while undergoing nasal surgery, and there is not much data available in Pakistan regarding EA in adults undergoing functional endoscopic sinus surgery…
- Trial name
- NCT07392983
- Testing
- Dexmedetomidine, Midazolam
- Where
- 2 sites in Pakistan
- Volunteers
- 146 people
- Sponsor
- Muhammad Aamir Latif
Adenoidectomy, Functional Endoscopic Sinus Surgery (FESS)
Prospective Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption
This proposed study will assess the hemodynamic effects and measure the systemic absorption of topically applied oxymetazoline in patients undergoing functional endoscopic sinus surgery, turbinate surgery, or adenoidectomy.
- Conditions
- Adenoidectomy, Functional Endoscopic Sinus Surgery (FESS), Turbinate Surgery
- Trial name
- NCT02453841
- Testing
- Oxymetazoline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Richard Cartabuke
Chronic Rhinosinusitis (Diagnosis)
Functional Endoscopic Sinus Surgery Study
The aim of this study is to evaluate the effect of the addition of epinephrine to bilateral real time ultrasound guided pterygopalatine ganglion blocks on intra-operative bleeding and blood loss during functional endoscopic sinus…
- Trial name
- FESS (NCT03970655)
- Testing
- Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 1, Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 2
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Florida
Dexmedetomidine, Functional Endoscopic Sinus
Intranasal Dexmedetomidine Versus Intravenous Dexmedetomidine for Improving Quality of Endoscopic Sinus Surgery
compare intranasal dexmedetomidine versus intravenous dexmedetomidine for improving quality of the operative field in Functional endoscopic sinus surgery
- Trial name
- NCT06081933
- Testing
- intranasal dexmedetomidine, intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Kafrelsheikh University