Clinical trials: Functional Impairment, open to volunteers
Functional Impairment, Frailty
A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among Older Veterans in Primary Care Settings
Maintaining functional status, or the ability to perform daily activities, is central to older adults' quality of life, health, and ability to remain independent.
- Trial name
- NCT06404970
- Testing
- Screening intervention, Standard bundle of implementation strategies, Enhanced bundle of implementation strategies
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- VA Office of Research and Development
Breast Cancer, Locally Advanced Breast Cancer
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing…
- Conditions
- Breast Cancer, Locally Advanced Breast Cancer, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT06727773
- Testing
- Memantine, Exercise Intervention, Exercise Control
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Peripheral Artery Disease
BEETroot Juice to Reverse Functional Impairment in PAD
The BEET PAD Trial is a multi-centered double-blind randomized clinical trial designed to determine whether beetroot juice, compared to placebo, improves six-minute walk distance at four month follow-up in people with lower…
- Trial name
- BEET PAD (NCT05624125)
- Testing
- Beetroot juice
- Where
- 4 sites in United States
- Volunteers
- 210 people
- Sponsor
- Northwestern University
Alzheimer's Disease (AD)
Amyloid-β Clearance Mechanisms in Alzheimer's Disease
The focus of this study is to examine the protein-plaque clearance (Aß) in relation to the blood-brain-barrier, the glymphatic system, brain lymphatic system and enzymatic degradation.
- Trial name
- AmyClearAD (NCT05059158)
- Testing
- positron emission tomography (PET)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cognitive Impairment, Cognitive Flexibility
Beta-1 Band Functional Connectivity Mediates the Effects of Acute Exercise on Cognitive Flexibility in Older Adults With Cognitive Impairment: A Randomized Controlled Trial
Objective: The effects of different exercise modalities (mind-body, aerobic, and resistance training) on cognitive flexibility and brain functional connectivity in cognitively impaired older adults are unknown, and the…
- Conditions
- Cognitive Impairment, Cognitive Flexibility, Brain Functional Connectivity
- Trial name
- NCT07854444
- Testing
- Baduanjin, Brisk walking, Resistance band
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai University of Sport
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cognition Disorders in Old Age, Cognitive and Behavioral Impairment
Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients
This study aims to evaluate the effect of L-arginine supplementation on cognitive function in geriatric patients. Eligible participants will receive either L-arginine (6 grams once daily) or placebo, and their cognitive…
- Trial name
- NCT07338682
- Testing
- L-Arginine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- German University in Cairo
Chronic Kidney Disease
Niaoduqing Granules in Older Adults With Impaired Kidney Function
This prospective real-world study will evaluate the clinical benefits of Niaoduqing Granules in older adults with impaired kidney function.
- Trial name
- NCT07741292
- Testing
- Intervention Name
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
Mild Cognitive Impairment (MCI)
Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity
The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI).
- Trial name
- ATHENA (NCT07741773)
- Testing
- EVOO-phenolics dietary supplement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Augusta University
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
MCI, Mild Cognitive Impairment
Telehealth-Adapted Compensatory Training and Intervention for Cognition
The goal of this clinical trial is to develop a five-week virtual cognitive training intervention for people with Mild Cognitive Impairment (MCI) based off an existing eight-week intervention.
- Conditions
- MCI, Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
- Trial name
- TACTIC (NCT07366346)
- Testing
- Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT-MCI), Brief Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (bME-CCT-MCI)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Myopia, Quality of Life
Functional Vision and Quality of Life in a Modern Society - With Emphasis on Myopia and Cerebral Visual Impairment Among Youth
Society has become increasingly digital, and many everyday services have been replaced by digital self-service solutions. This puts greater demands on our vision and our ability to interpret what we see.
- Trial name
- NCT07653074
- Testing
- ophthalmological examination
- Where
- Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Psychosis, Prodromal Schizophrenia
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk
This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability…
- Conditions
- Psychosis, Prodromal Schizophrenia, Prodromal Symptoms
- Trial name
- SCORES (NCT05131035)
- Testing
- SCORES (Specific COgnitive Remediation with Support)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Insomnia, Cognitive Impairment
RESET-BRAIN: REhabilitation of SleEp and CogniTive Impairment in BReast Cancer Survivors Using an App-based Intervention
The goal of the study is to investigate whether treating insomnia using app-based cognitive behavioral therapy for insomnia (CBT-I) can improve cognitive impairment in breast cancer survivors compared to an active control group…
- Conditions
- Insomnia, Cognitive Impairment, Breast Cancer
- Trial name
- RESET-BRAIN (NCT06553235)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep hygiene education
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Aarhus University Hospital
Mild Cognitive Impairment (MCI), Sarcopenia
Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment
Mild Cognitive Impairment (MCI) in older adults is linked to muscle loss (sarcopenia) and can lead to dementia, with pain further impacting cognitive and physical performance.
- Trial name
- NCT06828926
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ohio University
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Schizophrenia
Prucalopride for Cognitive Functioning in Schizophrenia
A core component of schizophrenia is neurocognitive impairment. The cognitive deficits are prominently seen in memory, attention, working memory, problem solving, processing speed and social cognition.
- Trial name
- NCT06474286
- Testing
- Prucalopride 1 MG
- Where
- India
- Volunteers
- 34 people
- Sponsor
- University of Pittsburgh
Generalized Anxiety Disorder
Pharmacokinetic Study of Buagafuran Capsules in Participants With Hepatic Impairment and Normal Hepatic Function
This study adopts a non-randomized, open label, parallel, single-dose design to evaluate the safety and pharmacokinetic characteristics of Buagafuran capsules in participants with hepatic impairment.
- Trial name
- NCT07457190
- Testing
- Buagafuran
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beijing Union Pharmaceutical Factory Ltd
Psoriasis
To Evaluate the Pharmacokinetics of Hemay005 Tablets in Subjects With Liver Damage
The purpose of this study was to evaluate the pharmacokinetics of Hemay 005 tablets in subjects with mild, moderate liver impairment and normal liver function, and to provide a basis for the formulation of clinical medication…
- Trial name
- NCT06376474
- Testing
- Hemay005
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ganzhou Hemay Pharmaceutical Co., Ltd