Clinical trials: Functional Insufficiency
Chronic Kidney Disease, Hyperuricemia
Compare the Renal Protective Effects of Febuxostat and Benzbromarone in CKD Chinese Patients
The purpose of this study is to determine whether febuxostat and benzbromarone could protect renal function in chinese, and which one could be better.
- Conditions
- Chronic Kidney Disease, Hyperuricemia, Abnormal Renal Function
- Trial name
- NCT02944214
- Testing
- Febuxostat, Benzbromarone
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shanghai 10th People's Hospital
Renal Insufficiency, Healthy
A Study in People With Normal Kidney Function and People With Reduced Kidney Function to Test How BI 1467335 is Processed in the Body
The primary objective of the current study is to investigate the influence of moderate renal impairment on the pharmacokinetics of multiple doses in comparison to a matched control group with normal renal function.
- Trial name
- NCT03302091
- Testing
- BI 1467335
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Alcoholic Liver Disease
Cognitive Function of Alcoholic Compensated Liver Cirrhosis
Differences in cognitive function between patients with viral and alcoholic compensated liver cirrhosis
- Trial name
- NCT04557774
- Testing
- Cognitive function test
- Where
- South Korea
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
End Stage Renal Failure on Dialysis, Frail Elderly Syndrome
The Effect of Intradialytic Exercise on the Physical Function of People Undergoing Hemodialysis
The investigators intend to recruit 50 patients into an intradialytic exercise study that will measure the impact of resistance bands exercises under the guidance of an exercise physiologist on the physical function of…
- Trial name
- IDEX (NCT03944824)
- Testing
- Exercise Plan using resistance bands, Modified Fried Frailty Scale
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Satellite Healthcare
Chronic Kidney Disease Stage 5
Exercise and Vascular Function in Haemodialysis Patients
The aim of this study is to evaluate whether a three month intra-dialytic exercise programme improves arterial function.
- Trial name
- NCT01591876
- Testing
- Intradialytic aerobic exercise, Progressive Muscle relaxation
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Queen Margaret University
Hepatic Insufficiency
A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function
This study is designed to evaluate how CP-690,550 is handled by the body in healthy volunteers who have mild and moderate hepatic impairment compared to healthy volunteers with normal hepatic function.
- Trial name
- NCT00969813
- Testing
- CP-690,550
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cardiorenal Syndrome
Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery
Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow.
- Trial name
- DECONGEST (NCT03684876)
- Testing
- diuretic use
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Kidney Disease
Pulsed Perfusion for Marginal Kidneys
Trends in organ donor pool are characterized by an increasing age and a shift towards cerebrovascular diseases as primary causes of death.
- Trial name
- PREDICTION (NCT02055950)
- Testing
- Storage of kidney in refrigerated solution, Kidney perfused by pulsatile machine
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Dyslipidemias, Children, Only
The Effect of Childhood Dyslipidemia on Endothelial and Renal Function
The aim of the study is to assess if abnormal lipid levels in childhood could cause early damage of the inner layer of the vessels, the endothelium.
- Conditions
- Dyslipidemias, Children, Only, Endothelial Dysfunction, Renal Dysfunction
- Trial name
- NCT03856476
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Ioannina
Chronic Kidney Disease
Vitamin D Supplementation and Cardiac Hypertrophy in Chronic Kidney Disease (CKD)
Patients with Chronic Kidney Disease (CKD) are upto 3.5 times more likely to die from diseases of heart and blood vessels (Cardiovascular Disease-CVD). Vitamin D insufficiency is very common in CKD and associated with CVD.
- Trial name
- 5C (NCT01323712)
- Testing
- Vitamin D Cholecalciferol
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's, University of London
Periodontitis, Airway Obstruction
Bergen Oral Respiratory Intervention Study
The purpose of this study is to investigate if treatment of periodontitis (gum disease) in a relatively young and healthy population can improve lung function.
- Conditions
- Periodontitis, Airway Obstruction, Lung Inflammation
- Trial name
- BORALIS (NCT04781153)
- Testing
- Periodontal treatment
- Where
- Norway
- Volunteers
- 62 people
- Sponsor
- Anders Røsland
Renal Injury
The Effect of Neuromuscular Electrical Stimulation (NMES) on the Renal Function and Renal Blood Flow
A randomized prospective controlled study aims to evaluate the effect of neuromuscular electrical stimulation on the renal function and renal blood flow of post partum women with acute kidney injury.
- Trial name
- NMES (NCT04580329)
- Testing
- neuromuscular electrical stimulation (NMES) in addition to routine hospital care, routine hospital care without NMES
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Ahmed talaat ahmed aly
Renal Impairment
Pharmacokinetics of Dabrafenib in Subjects With Renal Impairment
To characterize the pharmacokinetics and safety of dabrafenib following a single 100 mg oral dose in subjects with severe renal impairment and end stage renal disease not on dialysis.
- Trial name
- NCT02852239
- Testing
- dabrafenib
- Where
- 3 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Renal Failure
A Pharmacokinetics and Safety Study of Naproxcinod in Subjects With Impaired Renal Function
To study the pharmacokinetics and safety of naproxcinod in patients with impaired renal function
- Trial name
- HCT3012-X-106 (NCT00674856)
- Testing
- naproxcinod
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NicOx
Chronic Kidney Disease, Kidney Transplant
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol.
- Conditions
- Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
- Trial name
- RESTORE (NCT07222683)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Respiratory Depression, Anesthesia Morbidity
Effect of Interscalene Block on Ventilatory Function
Interscalene block with local anesthetic impairs ventilation (unilateral diaphragmatic dysfunction). Single injection of local anesthetic induced transitory dysfunction (< 24h).
- Conditions
- Respiratory Depression, Anesthesia Morbidity, Block
- Trial name
- KTBIS (NCT01740453)
- Testing
- ropivacaine 2 mg/ml
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Pierre and Marie Curie University
Functional Tricuspid Regurgitation
Echocardiographic Assessment and CLInical imPlication of Functional tricuSpid rEgurgitation in Heart Failure With Reduced or Preserved Ejection Fraction
Purpose Functional tricuspid regurgitation (FTR) has been shown to be associated with increased morbidity and mortality in several clinical conditions, including heart failure (HF) with reduced left ventricular ejection fraction…
- Trial name
- ECLIPSE-HF (NCT05209919)
- Testing
- Transthoracic Echocardiography
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Kidney Diseases, Kidney Failure, Chronic
Effect of Remote Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation
The purpose of this study was to investigate whether lower limb ischaemic preconditioning can improve renal function in patients undergoing living donor kidney transplantation
- Conditions
- Kidney Diseases, Kidney Failure, Chronic, Kidney Failure, Renal Insufficiency
- Trial name
- NCT01289548
- Testing
- remote ischaemic preconditioning
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Diabetic Nephropathies, Kidney Failure, Chronic
Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease
Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes.
- Conditions
- Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
- Trial name
- SUGARNSALT (NCT06217302)
- Testing
- Sotagliflozin
- Where
- 19 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- Alessandro Doria
Acute Kidney Injury
The Effects of Statin on Postoperative Renal Function in Valvular Heart Surgery: a Randomized, Placebo-controlled Study
The aim of this study is to examine the association between preoperative statin treatment and the incidence of postoperative acute kidney injury(AKI) in patients undergoing valvular heart surgery.
- Trial name
- NCT01909739
- Testing
- atrovastatin
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
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