Clinical trials: Functional Insufficiency
Congestive Heart Failure
Study to Evaluate the Effect of SLV320 in Addition to Chronic Furosemide Treatment on Renal Function in Subjects With Congestive Heart Failure and Impaired Renal Function
This is a randomized, double-blind, placebo-controlled, multi-center, sequential cohort study in subjects with congestive heart failure (CHF) and impaired renal function who are on stable furosemide treatment (³ 40 mg daily).
- Trial name
- NCT00568009
- Testing
- SLV320
- Where
- 72 sites in United States, Argentina and 8 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Solvay Pharmaceuticals
Chronic Kidney Disease, Urinary Angiotensinogen
Study of Urinary Angiotensinogen as a Marker to Warn the Deterioration of Renal Function in CKD Patients Early.
Chronic kidney disease (CKD) that results in end-stage renal disease (ESRD) is a major international health problem. Many clinical markers such as urine protein or eGFR(evaluated glomerular filtration rate),can estimate the renal…
- Trial name
- NCT01118494
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Fudan University
Acute Renal Failure, Chronic Renal Failure
New Non-invasive Methods for Real-time Monitoring of Organ Function.
Measuring novel proteins in the urine of surgical patients that can be used to diagnose impending acute or chronic renal failure.
- Trial name
- RTMKF (NCT00851851)
- Where
- United States
- Volunteers
- 641 people
- Sponsor
- Washington University School of Medicine
Chronic Kidney Disease
Safety and Pharmacokinetics of HRS-1780 in Healthy Subjects and Subjects With Impaired Renal Function
This is a multicenter, non-randomized, open-label, parallel-controlled study. The main objective is to evaluate the safety and pharmacokinetics of HRS-1780 in subjects with mild and moderate renal impairment versus healthy…
- Trial name
- NCT06039254
- Testing
- HRS-1780
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Adrenal Insufficiency
Circadian Function and Cardio-metabolic Risk in Adrenal Insufficiency
The purpose of this study is to compare cardio-metabolic risk, glucose tolerance, and night time blood pressure between healthy control subjects and patients with adrenal insufficiency.
- Trial name
- NCT03000231
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Hepatic Insufficiency
Evaluation Of Hepatic Impairment On AG-013736 Pharmacokinetics
This study will evaluate the effects of mild and moderate impairment of hepatic function on the single-dose pharmacokinetics, safety and tolerability of AG-013736.
- Trial name
- NCT00692341
- Testing
- AG-013736
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Kidney Disease (CKD), End-stage Renal Disease (ESRD)
Impact of Vitamin D Therapies on Chronic Kidney Disease
This investigation will consist of a prospective study utilizing two separate populations of patients with 25(OH)D deficiency, one population with chronic kidney disease (CKD) and one with normal renal function.
- Trial name
- NCT01222234
- Testing
- Cholecalciferol - CKD, Calcitriol - CKD, Cholecalciferol - non-CKD
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Kansas Medical Center
End Stage Renal Disease (ESRD)
The Effect of Gum Arabic (GA) on Residual Renal Function in Adult Dialysis Patients in Abu Dhabi
Gum Arabic (GA), derived from Acacia trees, has shown potential benefits in metabolic, renal, and inflammatory conditions. This study explores the impact of GA on residual renal function in end-stage renal disease (ESRD) patients…
- Trial name
- GAESRD (NCT06836206)
- Testing
- Gum Arabic, Water
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- Abu Dhabi Health Services Company
Renal Insufficiency, Healthy
Study of the Way the Body Takes up, Distributes, and Gets Rid of ACT-541468 in Subjects With Abnormal Kidney Function Compared to Healthy Subjects
Study of the way the body takes up, distributes, and gets rid of ACT-541468 in subjects with abnormal kidney function compared to healthy subjects
- Trial name
- NCT04024332
- Testing
- ACT-541468
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Neurodegenerative Diseases, Leukodystrophy
Home Exercise for Individuals With Neurodegenerative Disease
The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.
- Conditions
- Neurodegenerative Diseases, Leukodystrophy, Ataxia, LBSL
- Trial name
- NCT05443906
- Testing
- Home exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Kidney Function Decline, Chronic Kidney Disease
Comprehensive Kidney Function Assessment and Early Warning in Older Adults
This completed observational cohort study evaluates a comprehensive set of clinical and molecular markers of kidney function in two established cohorts of Chinese adults aged 60 years or older.
- Conditions
- Kidney Function Decline, Chronic Kidney Disease, Kidney Failure
- Trial name
- NCT07765134
- Where
- China
- Volunteers
- 5,588 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
End-Stage Renal Disease, Type 2 Diabetes Mellitus
A Double-Blind, Randomized, Placebo-Controlled Safety Study Evaluating the Effects of Residual Renal Function (RFF) in Patients With End-Stage Renal Disease and Type 2 Diabetes Mellitus on Peritoneal Dialysis
This study is a multi-center, double-blinded, randomized, study of bardoxolone methyl treatment in patients with End-Stage Renal Disease (ERSD) and Type 2 Diabetes Mellitus (T2DM) on peritoneal dialysis.
- Trial name
- NCT01576887
- Testing
- Bardoxolone Methyl 20 mg
- Sponsor
- Biogen
Acute Kidney Injury, Hypoperfusion
The Predictive Performance of Renal Ultrasound on Changes in Renal Clearance
The study will examine the ability of renal ultrasound (Doppler and Contrast Enhanced Ultrasound (CEUS)) in distinguishing ICU patients who exhibit increases in glomerular filtration rate (GFR) in response to fluid loading, from…
- Conditions
- Acute Kidney Injury, Hypoperfusion, Fluid Overload
- Trial name
- NCT04198168
- Testing
- IV crystalloid fluid bolus
- Where
- Denmark
- Volunteers
- 2 people
- Sponsor
- Aarhus University Hospital
Chronic Renal Failure
The Effect of Balance PD Solution on the Peritoneal Membrane in Patients on Automated Peritoneal Dialysis
To investigate the biocompatibility of the peritoneal dialysis (PD) solution balance in comparison to the conventional PD solution in APD(automated peritoneal dialysis) patients using the APD cycler sleep•safe.
- Trial name
- NCT01753154
- Testing
- Solution B (balance PD solution), Solution A (conventional PD solution)
- Where
- 7 sites in Poland, Spain
- Volunteers
- 25 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Acute Kidney Injury, Obesity
Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy (LSG)
This study evaluated the effect of a single preoperative dose of gabapentin on renal stress and kidney function following laparoscopic sleeve gastrectomy in adults with severe obesity.
- Trial name
- NCT06254183
- Testing
- Laparoscopic Sleeve Gastrectomy, gabapentin 1200 mg
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Chronic Kidney Disease
Aldosterone Blockade in Chronic Kidney Disease: Influence on Arterial Stiffness and Kidney Function
Patients with Chronic Kidney Disease (CKD) have a poor prognosis primarily due to cardiovascular disease. The cardiovascular risk can be assessed by measurements of arterial stiffness.
- Trial name
- ALBLOCK-2 (NCT01100203)
- Testing
- Eplerenone
- Where
- 2 sites in Denmark
- Volunteers
- 54 people
- Sponsor
- Lene Boesby
Functional Tricuspid Regurgitation
Right VEntricular Contractile ReSERVE in Functional Tricuspid Regurgitation
Aim of the study is to investigate the prognostic value of right ventricular contractile reserve in patients with functional tricuspid regurgitation undergoing tricuspid valve repair or replacement.
- Trial name
- RESERVE (NCT04141683)
- Testing
- Stress Echocardiography, Pressure volume loop analysis, Tricuspid valve repair or replacement
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Heart Center Leipzig - University Hospital
Healthy, Renal Impairment
A Single-Dose Study to Assess the Pharmacokinetics of Cabozantinib (XL184) Capsules in Subjects With Impaired Renal Function
The main objective of the trial is to compare the pharmacokinetics of a 60 mg dose of cabozantinib in adult subjects with impaired renal function compared with healthy adult subjects.
- Trial name
- NCT01761773
- Testing
- cabozantinib
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Exelixis
Chronic Kidney Diseases
Influence of Renal Function on the Circadian Variation of Cardiac Troponin
Cardiac troponin is the preferred biomarker for the diagnosis of acute myocardial infarction. Whereas the diagnosis is based on an increase and/or decrease in the concentrations of cardiac troponins with at least one value above…
- Trial name
- NCT02210897
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Chronic Kidney Disease, Congestive Heart Failure
Peritoneal Ultrafiltration to Treat Congestive Heart Failure
The purpose of this study is to determine whether the treatment of peritoneal ultrafiltration can improve survival and quality of life of refractory congestive heart failure with special accent on preserving residual renal…
- Trial name
- NCT02829450
- Testing
- peritoneal ultrafiltration
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Soroka University Medical Center
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