Clinical trials: Functional Insufficiency
Kidney Failure, Chronic
Effect of Exercise With Virtual Reality in Hemodialysis Patients
Background. An increase in inflammatory biomarkers is associated with impaired kidney function and increased cardiovascular risk and mortality.
- Trial name
- NCT05606484
- Testing
- Exercise with non-immersive virtual reality, Exercise with a static pedal
- Volunteers
- 80 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Mitral Regurgitation, Functional Mitral Regurgitation
PASCAL vs. MitralClip for Mitral Valve Transchatheter Edge-to-Edge Repair
Comparsion of the current two available TEER systems, the MitraClip with the PASCAL repair system in terms of their effectiveness and safety in patients with degenerative mitral regurgitation (DMR) and in patients with functional…
- Conditions
- Mitral Regurgitation, Functional Mitral Regurgitation, Degenerative Mitral Valve Regurgitation
- Trial name
- NCT05865938
- Testing
- PASCAL vs. MitraClip
- Where
- Germany
- Volunteers
- 214 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Chronic Kidney Disease Stage 3
Urinary Tubular Biomarkers for Chronic Kidney Disease
Currently used tests for chronic kidney injury only assess the function of one part of the kidney: the filter called the glomerulus. The other part, called the tubule, is disregarded.
- Trial name
- U-Tube 1 (NCT06732349)
- Testing
- Urinary tubular test panel
- Where
- Netherlands
- Volunteers
- 556 people
- Sponsor
- Erasmus Medical Center
Swallowing Disorder, Respiratory Insufficiency
The Impact of High-Flow Nasal Cannula on Swallow Function
Background: High-flow nasal cannula (HFNC) is a non-invasive heated and humidified oxygen delivery device that is capable of delivering high-flow rates.
- Trial name
- NCT03590457
- Testing
- Airvo 2; High-Flow nasal cannula system
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Critical Illness, Sepsis
MICU Recovery Clinic
Summary: Emerging data demonstrate long-term morbidity and mortality in those who survive critical illness. However, there is no data regarding long-term follow-up for ICU survivors.
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, ARDS
- Trial name
- NCT02560129
- Testing
- Questionnaires, Physical and Cognitive Function
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Hyperuricemia, Chronic Kidney Disease
The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure
In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on endothelial dysfunction in patients with chronic kidney disease.
- Trial name
- NCT00978653
- Testing
- allopurinol
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul University
Chronic Pancreatitis, Pancreatic Exocrine Insufficiency
Establishment and Clinical Application of Pancreatic Endocrine and Exocrine Function Tests
The goal of this observational study is to improve the epidemiological data of pancreatic exocrine insufficiency in China, determine the FE-1 cut-off value for the classification of PEI, and explore the characteristic differences…
- Conditions
- Chronic Pancreatitis, Pancreatic Exocrine Insufficiency, Diabetes Mellitus, Community Populations
- Trial name
- NCT06006312
- Testing
- fecal elastase-1 test, 72-hour fecal fat quantification, blood sample test
- Where
- China
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sickle Cell Disease, Kidney Failure, Chronic
Kidney Function in Sickle Cell Anemia
This is a prospective clinical cohort study that involves a baseline study visit followed by up to 3 annual follow-up study visits for a total follow-up of 36-48 months to evaluate the age- and sex-adjusted rate of change in…
- Trial name
- NCT03277547
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Kenneth Ataga MD
Healthy, Hepatic Insufficiency
A Study of LY3502970 in Participants With Impaired and Normal Liver Function
The main purpose of this study is to measure how much of LY3502970 gets into the bloodstream and how long it takes the body to eliminate it in participants with mild, moderate and severe impaired liver function compared to…
- Trial name
- NCT05882032
- Testing
- LY3502970
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hepatic Insufficiency, Healthy Subjects
Pharmacokinetics Of Jaktinib In Subjects With Hepatic Impairment And Normal Hepatic Function
This multi-center, open-label, parallel-controlled, single-dose Phase 1 study is being conducted to directly characterize the pharmacokinetic (PK) profiles and safety of Jaktinib following administration of a single oral dose in…
- Trial name
- NCT04993404
- Testing
- Jaktinib Hydrochloride Tablets
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Kidney Disease, Neoplasm
Oxaliplatin in Cancer Patients With Impaired Kidney Function
Oxaliplatin is an experimental anti-cancer drug that can shrink tumors such as colon cancer. However, because this drug can damage the kidneys, it is necessary to determine what doses of the drug can safely be given to patients…
- Conditions
- Kidney Disease, Neoplasm, Neoplasm Metastasis
- Trial name
- NCT00001835
- Testing
- Oxaliplatin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Acute Kidney Injury
Acute Kidney Injury After Cardiac Surgery
The investigators seek to determine whether a reduced preoperative renal functional reserve predicts postoperative acute kidney injury in patients with normal estimated glomerular filtration rates undergoing elective cardiac…
- Trial name
- NCT03457987
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Giessen
Spinal Cord Injuries, Cervical Spinal Cord Injury
Neurostimulation for Respiratory Function After Spinal Cord Injury
The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is: Changes in…
- Conditions
- Spinal Cord Injuries, Cervical Spinal Cord Injury, Respiratory Function Impaired
- Trial name
- NCT05756894
- Testing
- Neurostimulation, Repiratory training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Diabetes Mellitus, Type 2, Impaired Renal Function
Dapagliflozin Treatment in Type 2 Diabetes
Open label, mechanistic, single-arm study to evaluate the natriuretic effect of 2 weeks dapagliflozin treatment in T2DM patients with impaired renal function.
- Trial name
- NCT04620590
- Testing
- Dapagliflozin 10 MG [Farxiga]
- Where
- 2 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- Emerald Clinical Inc.
Chronic Kidney Disease
Targeted Nutritional Management for Children With Chronic Kidney Disease
To assess the effect of various nutritional interventions including the use of specific milk formulas on healthy status, growth parameters, body composition, skeletal muscle mass and functional capacity in patients with chronic…
- Trial name
- NCT07795190
- Volunteers
- 128 people
- Sponsor
- Assiut University
Chronic Kidney Disease (CKD), Kidney Transplant
Remote vs In-Person Prehabilitation for Kidney Transplant Candidates
Patients with advanced chronic kidney disease awaiting deceased-donor kidney transplantation frequently experience progressive functional decline, frailty, reduced mobility, and poor quality of life while on the transplant…
- Conditions
- Chronic Kidney Disease (CKD), Kidney Transplant, Frailty, Prehabilitation
- Trial name
- KIDFIT (NCT07701382)
- Testing
- In-Person Multimodal Prehabilitation, Remote Multimodal Prehabilitation
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Hospital Clinic of Barcelona
Posterior Tibial Tendon Insufficiency
Low-Level Laser Therapy and Orthotic Insole in Tibialis Posterior Tendon Insufficiency
The purpose of this study is to compare low-level laser therapy and insole interventions on pain, function and muscle strength in subjects with posterior tendon insufficiency.
- Trial name
- NCT03363074
- Testing
- Orthotic Insole, Low-Level Laser
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Chronic Kidney Diseases, Metabolic Syndrome
Theory-based Health Behaviour Change Intervention in Patients of Metabolic Syndrome With Chronic Kidney Disease
The pilot study will adopt a 2-arm, pretest-posttest, and assessor-blind randomized controlled trial design to examine the feasibility and acceptability of a theory-based health behaviour change intervention and examine its…
- Trial name
- NCT06527768
- Testing
- Theory-based health behaviour change interventio
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Ischemic Mitral Regurgitation, Functional Mitral Regurgitation
Epicardial Mitral Touch System for Mitral Insufficiency
To evaluate the safety and performance of the Mitral Touch System to treat mitral insufficiency in patients who are to undergo cardiac surgery with either a sternotomy or thoracotomy who present with moderate to severe ischemic…
- Trial name
- ENRAPTUS (NCT04396379)
- Testing
- Implant an epicardial device to reshape the mitral valve annulus
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mitre Medical Corp.
Airway Obstruction
The Association Between Pulmonary Function Tests and Difficult Airway
The airflow moving from mouth to the lungs, which can be measured by pulmonary function tests, may be affected by the anatomic disorders of the upper airway.
- Trial name
- NCT02325076
- Testing
- Spirodoc
- Where
- Turkey (Türkiye)
- Volunteers
- 202 people
- Sponsor
- Tokat Gaziosmanpasa University
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