Clinical trials: Functional Insufficiency
Renal Insufficiency, Chronic
A Study to Evaluate the Blood Levels, Safety, and Tolerability of PF-00734200 in Subjects With Impaired Kidney Function and Normal Kidney Function
The purpose of this study is to compare how PF-00734200 is adsorbed, distributed, broken down and eliminated by subjects with mild, moderate and severe kidney impairment, by subjects receiving chronic hemodialysis, and by…
- Trial name
- NCT00596518
- Testing
- PF-00734200
- Where
- 4 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pfizer
Acute Renal Failure
Carnitine, Aclycarnitine, Myocardial Function, and CRRT
Carnitine is essential for the transport of fatty acids into the mitochondria and energy production in different muscles, including the myocardium.
- Trial name
- NCT01941823
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Asha Moudgil
Kidney Failure Chronic, Cardiovascular Disease
Fish Oil and HDL Function in Patients on Maintenance Hemodialysis
Patients who receive maintenance hemodialysis have a very high risk of cardiovascular disease, and standard cholesterol-lowering treatments such as statins have not been shown to reduce cardiovascular events in this group.
- Conditions
- Kidney Failure Chronic, Cardiovascular Disease, HDL Cholesterol
- Trial name
- EFFLUX-HD (NCT07730385)
- Testing
- n-3 PUFA (fish oil)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Ovarian Function Insufficiency
Development of Ovarian Tissue Autograft in Order to Restore Ovarian Function
Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian…
- Trial name
- DATOR (NCT02846064)
- Testing
- Autograft of cryopreserved ovarian tissue
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Chronic Kidney Disease
Advanced Glycation End-products, Inflammation and Vascular Health in Chronic Kidney Disease
The purpose of the study is to learn more about how advanced glycation end-products can affect insulin resistance, inflammation and blood vessel health in people with kidney disease.
- Trial name
- NCT01769963
- Testing
- Research diet
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Alabama at Birmingham
Chronic Kidney Disease.
Paricalcitol and Endothelial Function in Chronic Kidney Disease Patients (the PENNY Study)
The primary aim of this study was to test the hypothesis that Paricalcitol, an active form of vitamin D, improved endothelial function in stage 3-4 chronic kidney disease (CKD) patients.
- Trial name
- PENNY (NCT01680198)
- Testing
- Paracalcitol
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Chronic Kidney Disease
Nitrite-boosting Therapy for Improving Physiological Function in Patients With Chronic Kidney Disease
Nitric oxide (NO) is an essential molecule in the body that is decreased in patients with chronic kidney disease (CKD), leading to reductions in vascular, movement ("motor") and cognitive functions.
- Trial name
- NCT03826147
- Testing
- Nitrate-rich beetroot juice, Nitrate-depleted beetroot juice
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Colorado, Boulder
Acute Kidney Injury
External Validation of IRRIV Test Relationship With Renal Functional Reserve
The assessment of renal functional reserve (RFR) has been proposed for the risk stratification of patients undergoing potentially nephrotoxic procedures.
- Trial name
- IRRIV-RFR (NCT03756402)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ospedale San Bortolo di Vicenza
Chronic Kidney Disease
Pedometers to Assess and Increase Physical Activity Among Children With Chronic Kidney Disease
Hypothesis #1: Most children with CKD stages 2-4, ESRD and kidney transplantation will report participation in physical activity that falls short of recommended levels of physical activity; Children on dialysis will be less…
- Trial name
- NCT01270529
- Testing
- Increasing Physical activity
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Adaptation, Psychological, Functional Insufficiency
Psychological Well-being Outcomes in Disease-free Survivors of Colorectal Cancer Following Curative Surgery
The purpose of the study is to investigate whether there are prognostic factors regarding the mental and functional adjustment of colon cancer patients following curative surgery.
- Trial name
- NCT01675505
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Aristotle University Of Thessaloniki
Renal Failure
Optimizing Cardiovascular Health and Physical Function in Hemodialysis Patients Through Volume Control and Exercise
This is a 12 month randomized clinical trial in which patients with renal failure undergoing maintenance hemodialysis (MHD) therapy will be placed on a volume reduction protocol that includes a novel low sodium dietary education…
- Trial name
- VCE (NCT02627066)
- Testing
- Volume Control, Volume Control + Exercise
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Illinois at Urbana-Champaign
Kidney Transplantation, Acute Kidney Tubular Necrosis
Effect of BM-MSCs in DCD Kidney Transplantation
This study is designed to determine the efficacy and safety of allogeneic bone marrow-derived mesenchymal stem cells in kidney transplantation from Chinese donation after citizen's death (DCD).
- Trial name
- NCT02561767
- Testing
- bone marrow-derived mesenchymal stem cells, Saline, Induction therapy (ATG or Basiliximab)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Acute Kidney Injury, Contrast Media
New Prognostic Kidney Function Markers in Emergency Patients New Markers of Kidney Function in ED Patients
NephroCheck is measuring the concentration of a certain protein combination in the urine of patients. In elevated values there is a probability of renal failure (already proven in intensive care patients).
- Trial name
- NCT02261909
- Where
- Germany
- Sponsor
- Krankenhaus Barmherzige Brüder, Regensburg
Tricuspid (Valve) Insufficiency (Rheumatic)
PROphylactic triCuspID Annuloplasty in Patients With Dilated Tricuspid Annulus
Patients elected to undergo mitral valve surgery (either repair or replacement) with less equal than moderate (≤+2) tricuspid regurgitation and dilated tricuspid annulus (>21mm/m2) at preoperative echocardiography will be…
- Trial name
- PROCIDA (NCT03129737)
- Testing
- Mitral valve surgery, Tricuspid valve annuloplasty
- Where
- 8 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Ettore Sansavini Health Science Foundation
Acute Renal Failure
Brief Title:Effect of a Preoperative Calorie Restriction on Renal Function After Cardiac Surgery
The aim of this study is to assess the effect of a diet prior to cardiac surgery on the common postoperative decline of renal function. Until now, there is no known drug or procedure to preserve the kidneys from this impairment.
- Trial name
- CR_KCH (NCT01534364)
- Testing
- calorie restriction
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- University of Cologne
Kidney Disease, Chronic
Diuretic Testing in Chronic Kidney Disease
The goal of this clinical trial is to predict the progression of chronic kidney disease by diuretic testing in patients with chronic kidney disease.
- Trial name
- U-TUBE 2 (NCT06841692)
- Testing
- Diuretic Testing
- Where
- Netherlands
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Systemic Inflammatory Response Syndrome, Oliguria
Bicarbonate and Lipocalin in Systemic Inflammatory Response Syndrome (SIRS) Study
The investigators will determine the feasibility, safety and efficacy of intravenous sodium bicarbonate in reducing progression to overt acute renal failure in patients with the systemic inflammatory response syndrome, and low…
- Conditions
- Systemic Inflammatory Response Syndrome, Oliguria, Renal Impairment
- Trial name
- BLISS (NCT00706771)
- Testing
- Sodium bicarbonate, Sodium chloride
- Where
- 2 sites in Australia
- Volunteers
- 70 people
- Sponsor
- Austin Health
End-Stage Renal Disease
Role of Extrarenal 1-Alpha-Hydroxylase in Patients With End Stage Renal Disease
The goal of this study is to evaluate the role of nutritional Vitamin D deficiency as a potential contributor to the morbidity witnessed in patients with end-stage renal disease
- Trial name
- NCT00677534
- Testing
- Cholecalciferol
- Volunteers
- 7 people
- Sponsor
- University of Kansas
Renal Insufficiency, Chronic
Functional Urodynamic Changes in Chronic Kidney Disease Patients and Does Insertion of Urinary Catheter Delay the Need for Kidney Dialysis
The aim of the investigators work is to describe the urodynamic results in the CKD (chronic kidney disease) grade 4 patients and to verify observations that urinary catheter may improve kidney function in those patients.
- Trial name
- NCT02731209
- Testing
- urinary catheter
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf Harofeh MC
Solid Tumours
Study to Assess Osimertinib in Patients w/ Adv Solid Tumours & Normal Kidney Function or Severe Kidney Impairment
The purpose of this study is to assess the effect of severe renal impairment on the levels of AZD9291 in the blood in patients with advanced solid tumours compared to patients with normal renal function
- Trial name
- NCT02923947
- Testing
- Osimertinib; AZD9291
- Where
- 11 sites in France, South Korea and 1 more
- Volunteers
- 16 people
- Sponsor
- AstraZeneca
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